DegronMD

Uniprot ID: Q3MII6

Source protein: TBC1 domain family member 25

Source gene: TBC1D25

Class: DEG_APCC_DBOX_1

Location: 520:528

E3 ligase: APC,CDC20,FZR1

DEGRON score: 0.5807

ASA_SCORE: 92.2

COIL: 0.8037

CONS_SCORE: 0.3282

DSS_SCORE: 0.558

HELIX: 0.1386

FCONS_SCORE: 1.0679

RIG_SCORE: 0.6984

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.N516S	TCGA-06-5416	GBM	TCGA	RRDPLVQLP	DEG_APCC_DBOX_1	0.2222
p.P528L	TCGA-90-A4ED	LUSC	TCGA	RRDPLVQLP	DEG_APCC_DBOX_1	0.6471
p.L513R	TCGA-A6-3809	COAD	TCGA	RRDPLVQLP	DEG_APCC_DBOX_1	0.1389
p.S519F	TCGA-AP-A1DV	UCEC	TCGA	RRDPLVQLP	DEG_APCC_DBOX_1	0.3056
p.S536Y	TCGA-L9-A444	LUAD	TCGA	RRDPLVQLP	DEG_APCC_DBOX_1	0.1111
p.I534T	SIDM00374	B-Cell Non-Hodgkin's Lymphoma	GDSC	RRDPLVQLP	DEG_APCC_DBOX_1	0.1667
p.I534T	ACH-002062	Lymphoma	CCLE	RRDPLVQLP	DEG_APCC_DBOX_1	0.1667
p.I534T	SLVL	haematopoietic_and_lymphoid_tissue	COSMIC	RRDPLVQLP	DEG_APCC_DBOX_1	0.1667

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q3MII6	TBC1 domain family member 25	DEG_APCC_DBOX_1	520:528	RRDPLVQLP	APC,CDC20,FZR1	0.5807	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons