DegronMD - Q8IYX3(CCDC116)

Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.P258L	TCGA-86-A4JF	LUAD	TCGA	SSSGVPEA	DEG_COP1_1	248:255	Mutation rewiring degron network	0.25
p.P258L	DO45317	LUAD	ICGC	SSSGVPEA	DEG_COP1_1	248:255	Mutation rewiring degron network	0.25
p.R139W	TCGA-AA-3521	COAD	TCGA	ARPSLSTVH	DEG_APCC_DBOX_1	126:134	Mutation rewiring degron network	0.1944
p.R139W	DO8079	COAD	ICGC	ARPSLSTVH	DEG_APCC_DBOX_1	126:134	Mutation rewiring degron network	0.1944
p.R139W	SIDM00253	Neuroblastoma	GDSC	ARPSLSTVH	DEG_APCC_DBOX_1	126:134	Mutation rewiring degron network	0.1944
p.R139W	ACH-002284	Neuroblastoma	CCLE	ARPSLSTVH	DEG_APCC_DBOX_1	126:134	Mutation rewiring degron network	0.1944
p.R139W	NB6	autonomic ganglia	COSMIC	ARPSLSTVH	DEG_APCC_DBOX_1	126:134	Mutation rewiring degron network	0.1944
p.P140L	TCGA-CG-5728	STAD	TCGA	ARPSLSTVH	DEG_APCC_DBOX_1	126:134	Mutation rewiring degron network	0.1667
p.P140L	DO38619	STAD	ICGC	ARPSLSTVH	DEG_APCC_DBOX_1	126:134	Mutation rewiring degron network	0.1667
p.R127W	TCGA-D3-A3ML	SKCM	TCGA	ARPSLSTVH	DEG_APCC_DBOX_1	126:134	Mutation altering degron motif	0.8634
p.R127W	TCGA-YD-A9TA	SKCM	TCGA	ARPSLSTVH	DEG_APCC_DBOX_1	126:134	Mutation altering degron motif	0.8634
p.R127W	DO47413	SKCM	ICGC	ARPSLSTVH	DEG_APCC_DBOX_1	126:134	Mutation altering degron motif	0.8634
p.R127W	DO219503	SKCM	ICGC	ARPSLSTVH	DEG_APCC_DBOX_1	126:134	Mutation altering degron motif	0.8634
p.R123Q	TCGA-DX-AB32	SARC	TCGA	ARPSLSTVH	DEG_APCC_DBOX_1	126:134	Mutation rewiring degron network	0.25
p.R123Q	DO220102	SARC	ICGC	ARPSLSTVH	DEG_APCC_DBOX_1	126:134	Mutation rewiring degron network	0.25
p.S131T	TCGA-EE-A2MC	SKCM	TCGA	ARPSLSTVH	DEG_APCC_DBOX_1	126:134	Mutation altering degron motif	0.6005
p.S131T	DO37559	SKCM	ICGC	ARPSLSTVH	DEG_APCC_DBOX_1	126:134	Mutation altering degron motif	0.6005
p.R137S	TCGA-EO-A3B0	UCEC	TCGA	ARPSLSTVH	DEG_APCC_DBOX_1	126:134	Mutation rewiring degron network	0.25
p.R137S	DO219773	UCEC	ICGC	ARPSLSTVH	DEG_APCC_DBOX_1	126:134	Mutation rewiring degron network	0.25
p.S153C	TCGA-PK-A5HB	ACC	TCGA	PSSSS	DEG_SPOP_SBC_1	151:155	Mutation altering degron motif	0.7541
p.S402I	TCGA-X6-A7WB	SARC	TCGA	PCSSS	DEG_SPOP_SBC_1	403:407	Mutation rewiring degron network	0.3056
p.S402I	DO220314	SARC	ICGC	PCSSS	DEG_SPOP_SBC_1	403:407	Mutation rewiring degron network	0.3056
p.S243A	TCGA-XK-AAIV	PRAD	TCGA	SSSGVPEA	DEG_COP1_1	248:255	Mutation rewiring degron network	0.1944
p.S243A	DO51405	PRAD	ICGC	SSSGVPEA	DEG_COP1_1	248:255	Mutation rewiring degron network	0.1944
p.E264K	DO228483	BRCA	ICGC	SSSGVPEA	DEG_COP1_1	248:255	Mutation rewiring degron network	0.0833
p.E264K	DO230659	LAML	ICGC	SSSGVPEA	DEG_COP1_1	248:255	Mutation rewiring degron network	0.0833
p.E264K	DO231140	LAML	ICGC	SSSGVPEA	DEG_COP1_1	248:255	Mutation rewiring degron network	0.0833
p.W241S	DO6504	CLLE	ICGC	SSSGVPEA	DEG_COP1_1	248:255	Mutation rewiring degron network	0.1389
p.G121R	DO230334	COCA	ICGC	ARPSLSTVH	DEG_APCC_DBOX_1	126:134	Mutation rewiring degron network	0.1944
p.G121R	DO229005	COCA	ICGC	ARPSLSTVH	DEG_APCC_DBOX_1	126:134	Mutation rewiring degron network	0.1944
p.V252M	DO50341	ESAD	ICGC	SSSGVPEA	DEG_COP1_1	248:255	Mutation altering degron motif	0.7208
p.V252M	SIDM00926	Non-Small Cell Lung Carcinoma	GDSC	SSSGVPEA	DEG_COP1_1	248:255	Mutation altering degron motif	0.7208
p.V252M	SIDM01090	Colorectal Carcinoma	GDSC	SSSGVPEA	DEG_COP1_1	248:255	Mutation altering degron motif	0.7208
p.V252M	SIDM00969	Ovarian Carcinoma	GDSC	SSSGVPEA	DEG_COP1_1	248:255	Mutation altering degron motif	0.7208
p.V252M	SIDM00633	Breast Carcinoma	GDSC	SSSGVPEA	DEG_COP1_1	248:255	Mutation altering degron motif	0.7208
p.V252M	SIDM00650	Small Cell Lung Carcinoma	GDSC	SSSGVPEA	DEG_COP1_1	248:255	Mutation altering degron motif	0.7208
p.V252M	SIDM00309	Mesothelioma	GDSC	SSSGVPEA	DEG_COP1_1	248:255	Mutation altering degron motif	0.7208
p.V252M	SIDM01681	Non-Cancerous	GDSC	SSSGVPEA	DEG_COP1_1	248:255	Mutation altering degron motif	0.7208
p.G251C	DO228986	LICA	ICGC	SSSGVPEA	DEG_COP1_1	248:255	Mutation altering degron motif	0.6489
p.L142H	DO222837	MELA	ICGC	ARPSLSTVH	DEG_APCC_DBOX_1	126:134	Mutation rewiring degron network	0.1111
p.L142H	DO222837	MELA	ICGC	PSSSS	DEG_SPOP_SBC_1	151:155	Mutation rewiring degron network	0.0833
p.R137H	SIDM02047	Colorectal Carcinoma	GDSC	ARPSLSTVH	DEG_APCC_DBOX_1	126:134	Mutation rewiring degron network	0.25
p.R123W	SIDM00958	Chronic Myelogenous Leukemia	GDSC	ARPSLSTVH	DEG_APCC_DBOX_1	126:134	Mutation rewiring degron network	0.25
p.R123W	ACH-000920	Leukemia	CCLE	ARPSLSTVH	DEG_APCC_DBOX_1	126:134	Mutation rewiring degron network	0.25
p.R123W	ACH-001991	Primary	CCLE	ARPSLSTVH	DEG_APCC_DBOX_1	126:134	Mutation rewiring degron network	0.25
p.S131I	SIDM01169	Ovarian Carcinoma	GDSC	ARPSLSTVH	DEG_APCC_DBOX_1	126:134	Mutation altering degron motif	0.623
p.S131I	ACH-000885	Ovarian Cancer	CCLE	ARPSLSTVH	DEG_APCC_DBOX_1	126:134	Mutation altering degron motif	0.623
p.S131I	TOV-21G	ovary	COSMIC	ARPSLSTVH	DEG_APCC_DBOX_1	126:134	Mutation altering degron motif	0.623
p.K412R	SIDM00967	Ovarian Carcinoma	GDSC	PCSSS	DEG_SPOP_SBC_1	403:407	Mutation substituting flanking lysine	0.3056
p.K412R	SIDM00203	Ewing's Sarcoma	GDSC	PCSSS	DEG_SPOP_SBC_1	403:407	Mutation substituting flanking lysine	0.3056
p.A395D	SIDM01080	Oral Cavity Carcinoma	GDSC	PCSSS	DEG_SPOP_SBC_1	403:407	Mutation rewiring degron network	0.1111
p.A395D	ACH-000181	Head and Neck Cancer	CCLE	PCSSS	DEG_SPOP_SBC_1	403:407	Mutation rewiring degron network	0.1111
p.A395D	SCC-9	upper aerodigestive tract	COSMIC	PCSSS	DEG_SPOP_SBC_1	403:407	Mutation rewiring degron network	0.1111
p.G247V	SIDM00694	Other Solid Cancers	GDSC	SSSGVPEA	DEG_COP1_1	248:255	Mutation rewiring degron network	0.3056
p.V133I	SIDM01113	Other Sarcomas	GDSC	ARPSLSTVH	DEG_APCC_DBOX_1	126:134	Mutation altering degron motif	0.5965
p.V133I	ACH-000939	Sarcoma	CCLE	ARPSLSTVH	DEG_APCC_DBOX_1	126:134	Mutation altering degron motif	0.5965
p.V133I	SK-UT-1	soft tissue	COSMIC	ARPSLSTVH	DEG_APCC_DBOX_1	126:134	Mutation altering degron motif	0.5965
p.G120D	SIDM00217	Colorectal Carcinoma	GDSC	ARPSLSTVH	DEG_APCC_DBOX_1	126:134	Mutation rewiring degron network	0.1667
p.G120D	ACH-000999	Colon/Colorectal Cancer	CCLE	ARPSLSTVH	DEG_APCC_DBOX_1	126:134	Mutation rewiring degron network	0.1667
p.G120D	SNU-1040	large intestine	COSMIC	ARPSLSTVH	DEG_APCC_DBOX_1	126:134	Mutation rewiring degron network	0.1667
p.H146Y	ACH-002287	Colon/Colorectal Cancer	CCLE	PSSSS	DEG_SPOP_SBC_1	151:155	Mutation rewiring degron network	0.1944
p.H146Y	NCI-H630	large intestine	COSMIC	PSSSS	DEG_SPOP_SBC_1	151:155	Mutation rewiring degron network	0.1944

DegronMD: protein-targeted degradation, mutation and drug response to degrons

CCDC116

UniProt ID: Q8IYX3

Entrez ID: 164592

Protein name: Coiled-coil domain-containing protein 116

External links: UniprotKB HGNC RefSeq COSMIC

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Kaplan plot for CCDC116 in