DegronMD

Uniprot ID: Q8IYX3

Source protein: Coiled-coil domain-containing protein 116

Source gene: CCDC116

Class: DEG_APCC_DBOX_1

Location: 126:134

E3 ligase: APC,CDC20,FZR1

DEGRON score: 0.6548

ASA_SCORE: 82.9333

COIL: 0.694

CONS_SCORE: 0.8561

DSS_SCORE: 0.6327

HELIX: 0.0609

FCONS_SCORE: 1.041

RIG_SCORE: 0.6391

Degron related mutations and impact score

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Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.R127W	TCGA-D3-A3ML	SKCM	TCGA	ARPSLSTVH	DEG_APCC_DBOX_1	0.8634
p.R127W	TCGA-YD-A9TA	SKCM	TCGA	ARPSLSTVH	DEG_APCC_DBOX_1	0.8634
p.R127W	DO47413	SKCM	ICGC	ARPSLSTVH	DEG_APCC_DBOX_1	0.8634
p.R127W	DO219503	SKCM	ICGC	ARPSLSTVH	DEG_APCC_DBOX_1	0.8634
p.S131I	SIDM01169	Ovarian Carcinoma	GDSC	ARPSLSTVH	DEG_APCC_DBOX_1	0.623
p.S131I	ACH-000885	Ovarian Cancer	CCLE	ARPSLSTVH	DEG_APCC_DBOX_1	0.623
p.S131I	TOV-21G	ovary	COSMIC	ARPSLSTVH	DEG_APCC_DBOX_1	0.623
p.S131T	TCGA-EE-A2MC	SKCM	TCGA	ARPSLSTVH	DEG_APCC_DBOX_1	0.6005
p.S131T	DO37559	SKCM	ICGC	ARPSLSTVH	DEG_APCC_DBOX_1	0.6005
p.V133I	SIDM01113	Other Sarcomas	GDSC	ARPSLSTVH	DEG_APCC_DBOX_1	0.5965
p.V133I	ACH-000939	Sarcoma	CCLE	ARPSLSTVH	DEG_APCC_DBOX_1	0.5965
p.V133I	SK-UT-1	soft_tissue	COSMIC	ARPSLSTVH	DEG_APCC_DBOX_1	0.5965
p.R123Q	TCGA-DX-AB32	SARC	TCGA	ARPSLSTVH	DEG_APCC_DBOX_1	0.25
p.R123Q	DO220102	SARC	ICGC	ARPSLSTVH	DEG_APCC_DBOX_1	0.25
p.R137S	TCGA-EO-A3B0	UCEC	TCGA	ARPSLSTVH	DEG_APCC_DBOX_1	0.25
p.R137S	DO219773	UCEC	ICGC	ARPSLSTVH	DEG_APCC_DBOX_1	0.25
p.R137H	SIDM02047	Colorectal Carcinoma	GDSC	ARPSLSTVH	DEG_APCC_DBOX_1	0.25
p.R123W	SIDM00958	Chronic Myelogenous Leukemia	GDSC	ARPSLSTVH	DEG_APCC_DBOX_1	0.25
p.R123W	ACH-000920	Leukemia	CCLE	ARPSLSTVH	DEG_APCC_DBOX_1	0.25
p.R123W	ACH-001991	Primary	CCLE	ARPSLSTVH	DEG_APCC_DBOX_1	0.25
p.R139W	TCGA-AA-3521	COAD	TCGA	ARPSLSTVH	DEG_APCC_DBOX_1	0.1944
p.R139W	DO8079	COAD	ICGC	ARPSLSTVH	DEG_APCC_DBOX_1	0.1944
p.R139W	SIDM00253	Neuroblastoma	GDSC	ARPSLSTVH	DEG_APCC_DBOX_1	0.1944
p.R139W	ACH-002284	Neuroblastoma	CCLE	ARPSLSTVH	DEG_APCC_DBOX_1	0.1944
p.R139W	NB6	autonomic_ganglia	COSMIC	ARPSLSTVH	DEG_APCC_DBOX_1	0.1944

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Drug responses associated with CCDC116 mutations

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Sample	Cancer	Mutation (In Degron?)	Dataset	Drug	IC50
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All proteins holding degron of ARPSLSTVH

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Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q8IYX3	Coiled-coil domain-containing protein 116	DEG_APCC_DBOX_1	126:134	ARPSLSTVH	APC,CDC20,FZR1	0.6548	More...

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DegronMD: protein-targeted degradation, mutation and drug response to degrons

Degron: ARPSLSTVH

Degron related mutations and impact score

Drug responses associated with CCDC116 mutations

All proteins holding degron of ARPSLSTVH