DegronMD

Uniprot ID: Q8IYX3

Source protein: Coiled-coil domain-containing protein 116

Source gene: CCDC116

Class: DEG_APCC_DBOX_1

Location: 126:134

E3 ligase: APC,CDC20,FZR1

DEGRON score: 0.6548

ASA_SCORE: 82.9333

COIL: 0.694

CONS_SCORE: 0.8561

DSS_SCORE: 0.6327

HELIX: 0.0609

FCONS_SCORE: 1.041

RIG_SCORE: 0.6391

Degron related mutations and impact score

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.R139W	TCGA-AA-3521	COAD	TCGA	ARPSLSTVH	DEG_APCC_DBOX_1	0.1944
p.R139W	DO8079	COAD	ICGC	ARPSLSTVH	DEG_APCC_DBOX_1	0.1944
p.R139W	SIDM00253	Neuroblastoma	GDSC	ARPSLSTVH	DEG_APCC_DBOX_1	0.1944
p.R139W	ACH-002284	Neuroblastoma	CCLE	ARPSLSTVH	DEG_APCC_DBOX_1	0.1944
p.R139W	NB6	autonomic_ganglia	COSMIC	ARPSLSTVH	DEG_APCC_DBOX_1	0.1944
p.P140L	TCGA-CG-5728	STAD	TCGA	ARPSLSTVH	DEG_APCC_DBOX_1	0.1667
p.P140L	DO38619	STAD	ICGC	ARPSLSTVH	DEG_APCC_DBOX_1	0.1667
p.R127W	TCGA-D3-A3ML	SKCM	TCGA	ARPSLSTVH	DEG_APCC_DBOX_1	0.8634
p.R127W	TCGA-YD-A9TA	SKCM	TCGA	ARPSLSTVH	DEG_APCC_DBOX_1	0.8634
p.R127W	DO47413	SKCM	ICGC	ARPSLSTVH	DEG_APCC_DBOX_1	0.8634
p.R127W	DO219503	SKCM	ICGC	ARPSLSTVH	DEG_APCC_DBOX_1	0.8634
p.R123Q	TCGA-DX-AB32	SARC	TCGA	ARPSLSTVH	DEG_APCC_DBOX_1	0.25
p.R123Q	DO220102	SARC	ICGC	ARPSLSTVH	DEG_APCC_DBOX_1	0.25
p.S131T	TCGA-EE-A2MC	SKCM	TCGA	ARPSLSTVH	DEG_APCC_DBOX_1	0.6005
p.S131T	DO37559	SKCM	ICGC	ARPSLSTVH	DEG_APCC_DBOX_1	0.6005
p.R137S	TCGA-EO-A3B0	UCEC	TCGA	ARPSLSTVH	DEG_APCC_DBOX_1	0.25
p.R137S	DO219773	UCEC	ICGC	ARPSLSTVH	DEG_APCC_DBOX_1	0.25
p.G121R	DO230334	COCA	ICGC	ARPSLSTVH	DEG_APCC_DBOX_1	0.1944
p.G121R	DO229005	COCA	ICGC	ARPSLSTVH	DEG_APCC_DBOX_1	0.1944
p.L142H	DO222837	MELA	ICGC	ARPSLSTVH	DEG_APCC_DBOX_1	0.1111
p.R137H	SIDM02047	Colorectal Carcinoma	GDSC	ARPSLSTVH	DEG_APCC_DBOX_1	0.25
p.R123W	SIDM00958	Chronic Myelogenous Leukemia	GDSC	ARPSLSTVH	DEG_APCC_DBOX_1	0.25
p.R123W	ACH-000920	Leukemia	CCLE	ARPSLSTVH	DEG_APCC_DBOX_1	0.25
p.R123W	ACH-001991	Primary	CCLE	ARPSLSTVH	DEG_APCC_DBOX_1	0.25
p.S131I	SIDM01169	Ovarian Carcinoma	GDSC	ARPSLSTVH	DEG_APCC_DBOX_1	0.623
p.S131I	ACH-000885	Ovarian Cancer	CCLE	ARPSLSTVH	DEG_APCC_DBOX_1	0.623
p.S131I	TOV-21G	ovary	COSMIC	ARPSLSTVH	DEG_APCC_DBOX_1	0.623
p.V133I	SIDM01113	Other Sarcomas	GDSC	ARPSLSTVH	DEG_APCC_DBOX_1	0.5965
p.V133I	ACH-000939	Sarcoma	CCLE	ARPSLSTVH	DEG_APCC_DBOX_1	0.5965
p.V133I	SK-UT-1	soft_tissue	COSMIC	ARPSLSTVH	DEG_APCC_DBOX_1	0.5965
p.G120D	SIDM00217	Colorectal Carcinoma	GDSC	ARPSLSTVH	DEG_APCC_DBOX_1	0.1667
p.G120D	ACH-000999	Colon/Colorectal Cancer	CCLE	ARPSLSTVH	DEG_APCC_DBOX_1	0.1667
p.G120D	SNU-1040	large_intestine	COSMIC	ARPSLSTVH	DEG_APCC_DBOX_1	0.1667

DegronMD: protein-targeted degradation, mutation and drug response to degrons

Degron: ARPSLSTVH

Degron related mutations and impact score

Drug responses associated with CCDC116 mutations

All proteins holding degron of ARPSLSTVH

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q8IYX3	Coiled-coil domain-containing protein 116	DEG_APCC_DBOX_1	126:134	ARPSLSTVH	APC,CDC20,FZR1	0.6548	More...