DegronMD

Uniprot ID: Q8IYX3

Source protein: Coiled-coil domain-containing protein 116

Source gene: CCDC116

Class: DEG_COP1_1

Location: 248:255

E3 ligase: COP1

DEGRON score: 0.8294

ASA_SCORE: 66.5625

COIL: 0.8188

CONS_SCORE: 0.6676

DSS_SCORE: 0.5825

HELIX: 0.0946

FCONS_SCORE: 0.805

RIG_SCORE: 0.5764

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.P258L	TCGA-86-A4JF	LUAD	TCGA	SSSGVPEA	DEG_COP1_1	0.25
p.P258L	DO45317	LUAD	ICGC	SSSGVPEA	DEG_COP1_1	0.25
p.S243A	TCGA-XK-AAIV	PRAD	TCGA	SSSGVPEA	DEG_COP1_1	0.1944
p.S243A	DO51405	PRAD	ICGC	SSSGVPEA	DEG_COP1_1	0.1944
p.E264K	DO228483	BRCA	ICGC	SSSGVPEA	DEG_COP1_1	0.0833
p.E264K	DO230659	LAML	ICGC	SSSGVPEA	DEG_COP1_1	0.0833
p.E264K	DO231140	LAML	ICGC	SSSGVPEA	DEG_COP1_1	0.0833
p.W241S	DO6504	CLLE	ICGC	SSSGVPEA	DEG_COP1_1	0.1389
p.V252M	DO50341	ESAD	ICGC	SSSGVPEA	DEG_COP1_1	0.7208
p.V252M	SIDM00926	Non-Small Cell Lung Carcinoma	GDSC	SSSGVPEA	DEG_COP1_1	0.7208
p.V252M	SIDM01090	Colorectal Carcinoma	GDSC	SSSGVPEA	DEG_COP1_1	0.7208
p.V252M	SIDM00969	Ovarian Carcinoma	GDSC	SSSGVPEA	DEG_COP1_1	0.7208
p.V252M	SIDM00633	Breast Carcinoma	GDSC	SSSGVPEA	DEG_COP1_1	0.7208
p.V252M	SIDM00650	Small Cell Lung Carcinoma	GDSC	SSSGVPEA	DEG_COP1_1	0.7208
p.V252M	SIDM00309	Mesothelioma	GDSC	SSSGVPEA	DEG_COP1_1	0.7208
p.V252M	SIDM01681	Non-Cancerous	GDSC	SSSGVPEA	DEG_COP1_1	0.7208
p.G251C	DO228986	LICA	ICGC	SSSGVPEA	DEG_COP1_1	0.6489
p.G247V	SIDM00694	Other Solid Cancers	GDSC	SSSGVPEA	DEG_COP1_1	0.3056

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q8IYX3	Coiled-coil domain-containing protein 116	DEG_COP1_1	248:255	SSSGVPEA	COP1	0.8294	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons