DegronMD - O75052(NOS1AP)

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Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.E284Q	TCGA-52-7810	LUSC	TCGA	PSSSS	DEG_SPOP_SBC_1	272:276	Mutation rewiring degron network	0.1111
p.L271F	TCGA-AN-A046	BRCA	TCGA	PSSSS	DEG_SPOP_SBC_1	272:276	Mutation rewiring degron network	0.3056
p.L271F	DO1285	BRCA	ICGC	PSSSS	DEG_SPOP_SBC_1	272:276	Mutation rewiring degron network	0.3056
p.S276P	TCGA-AN-A04D	BRCA	TCGA	PSSSS	DEG_SPOP_SBC_1	272:276	Mutation altering degron motif	0.6752
p.G282S	TCGA-AZ-6605	COAD	TCGA	PSSSS	DEG_SPOP_SBC_1	272:276	Mutation rewiring degron network	0.1667
p.G282S	DO8762	COAD	ICGC	PSSSS	DEG_SPOP_SBC_1	272:276	Mutation rewiring degron network	0.1667
p.P267L	TCGA-FR-A8YC	SKCM	TCGA	PSSSS	DEG_SPOP_SBC_1	272:276	Mutation rewiring degron network	0.1944
p.P267L	DO50301	SKCM	ICGC	PSSSS	DEG_SPOP_SBC_1	272:276	Mutation rewiring degron network	0.1944
p.S275F	TCGA-W3-AA1V	SKCM	TCGA	PSSSS	DEG_SPOP_SBC_1	272:276	Mutation altering degron motif	0.7982
p.S275F	DO220873	MELA	ICGC	PSSSS	DEG_SPOP_SBC_1	272:276	Mutation altering degron motif	0.7982
p.S275F	DO51276	SKCM	ICGC	PSSSS	DEG_SPOP_SBC_1	272:276	Mutation altering degron motif	0.7982
p.S276L	TCGA-YD-A89C	SKCM	TCGA	PSSSS	DEG_SPOP_SBC_1	272:276	Mutation altering degron motif	0.7667
p.S276L	DO219501	SKCM	ICGC	PSSSS	DEG_SPOP_SBC_1	272:276	Mutation altering degron motif	0.7667
p.S271P	DO2222	BRCA	ICGC	PSSSS	DEG_SPOP_SBC_1	272:276	Mutation rewiring degron network	0.3056
p.S275P	DO48264	ESCA	ICGC	PSSSS	DEG_SPOP_SBC_1	272:276	Mutation altering degron motif	0.6752
p.M269I	DO228924	LICA	ICGC	PSSSS	DEG_SPOP_SBC_1	272:276	Mutation rewiring degron network	0.25
p.P286L	DO228963	LICA	ICGC	PSSSS	DEG_SPOP_SBC_1	272:276	Mutation rewiring degron network	0.0556
p.G407V	DO229031	LICA	ICGC	PTTPKPE	DEG_SCF_FBW7_2	391:397	Mutation rewiring degron network	0.0556
p.A406S	DO50967	LICA	ICGC	PTTPKPE	DEG_SCF_FBW7_2	391:397	Mutation rewiring degron network	0.0833
p.H400Y	DO45370	LUAD	ICGC	PTTPKPE	DEG_SCF_FBW7_2	391:397	Mutation rewiring degron network	0.25
p.E397D	DO26052	LUAD	ICGC	PTTPKPE	DEG_SCF_FBW7_2	391:397	Mutation altering degron motif	0.6758
p.E279Q	DO27381	LUSC	ICGC	PSSSS	DEG_SPOP_SBC_1	272:276	Mutation rewiring degron network	0.25
p.P386L	DO229456	SKCA	ICGC	PTTPKPE	DEG_SCF_FBW7_2	391:397	Mutation rewiring degron network	0.1944
p.S401L	DO37831	SKCM	ICGC	PTTPKPE	DEG_SCF_FBW7_2	391:397	Mutation rewiring degron network	0.2222
p.L399M	DO47849	STAD	ICGC	PTTPKPE	DEG_SCF_FBW7_2	391:397	Mutation rewiring degron network	0.2778
p.V387M	DO42560	UCEC	ICGC	PTTPKPE	DEG_SCF_FBW7_2	391:397	Mutation rewiring degron network	0.2222
p.C389Y	SIDM02015	Colorectal Carcinoma	GDSC	PTTPKPE	DEG_SCF_FBW7_2	391:397	Mutation rewiring degron network	0.2778
p.S273A	SIDM00321	Ovarian Carcinoma	GDSC	PSSSS	DEG_SPOP_SBC_1	272:276	Mutation altering degron motif	0.6477
p.S273A	SIDM00293	Small Cell Lung Carcinoma	GDSC	PSSSS	DEG_SPOP_SBC_1	272:276	Mutation altering degron motif	0.6477
p.S273A	SIDM00619	Thyroid Gland Carcinoma	GDSC	PSSSS	DEG_SPOP_SBC_1	272:276	Mutation altering degron motif	0.6477
p.S273A	SIDM00502	B-Lymphoblastic Leukemia	GDSC	PSSSS	DEG_SPOP_SBC_1	272:276	Mutation altering degron motif	0.6477
p.S273A	SIDM00280	Gastric Carcinoma	GDSC	PSSSS	DEG_SPOP_SBC_1	272:276	Mutation altering degron motif	0.6477
p.S273A	SIDM01061	Oral Cavity Carcinoma	GDSC	PSSSS	DEG_SPOP_SBC_1	272:276	Mutation altering degron motif	0.6477
p.S273A	SIDM00302	Other Solid Cancers	GDSC	PSSSS	DEG_SPOP_SBC_1	272:276	Mutation altering degron motif	0.6477
p.A406V	SIDM00967	Ovarian Carcinoma	GDSC	PTTPKPE	DEG_SCF_FBW7_2	391:397	Mutation rewiring degron network	0.0833
p.P272S	SIDM00581	Glioblastoma	GDSC	PSSSS	DEG_SPOP_SBC_1	272:276	Mutation altering degron motif	0.6752
p.P272S	ACH-000738	Brain Cancer	CCLE	PSSSS	DEG_SPOP_SBC_1	272:276	Mutation altering degron motif	0.6752
p.P272S	GB-1	central nervous system	COSMIC	PSSSS	DEG_SPOP_SBC_1	272:276	Mutation altering degron motif	0.6752
p.K395M	SIDM00448	B-Cell Non-Hodgkin's Lymphoma	GDSC	PTTPKPE	DEG_SCF_FBW7_2	391:397	Mutation altering degron motif	0.6951
p.K395M	RC-K8	haematopoietic and lymphoid tissue	COSMIC	PTTPKPE	DEG_SCF_FBW7_2	391:397	Mutation altering degron motif	0.6951
p.P402S	SIDM00839	Colorectal Carcinoma	GDSC	PTTPKPE	DEG_SCF_FBW7_2	391:397	Mutation rewiring degron network	0.1944
p.P402S	LoVo	large intestine	COSMIC	PTTPKPE	DEG_SCF_FBW7_2	391:397	Mutation rewiring degron network	0.1944
p.A407V	SNU-1040	large intestine	COSMIC	PTTPKPE	DEG_SCF_FBW7_2	391:397	Mutation rewiring degron network	0.0556
p.K390M	RC-K8	haematopoietic and lymphoid tissue	COSMIC	PTTPKPE	DEG_SCF_FBW7_2	391:397	Mutation rewiring degron network	0.3056
p.P267S	GB-1	central nervous system	COSMIC	PSSSS	DEG_SPOP_SBC_1	272:276	Mutation rewiring degron network	0.1944
p.P397S	LoVo	large intestine	COSMIC	PTTPKPE	DEG_SCF_FBW7_2	391:397	Mutation altering degron motif	0.6752

Kaplan plot for NOS1AP in

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*NOTE: the Kaplan plots were collected from OncoLnc

DegronMD: protein-targeted degradation, mutation and drug response to degrons

NOS1AP

UniProt ID: O75052

Entrez ID: 9722

Protein name: Carboxyl-terminal PDZ ligand of neuronal nitric oxide synthase protein (C-terminal PDZ ligand of neuronal nitric oxide synthase protein) (Nitric oxide synthase 1 adaptor protein)

External links: UniprotKB HGNC RefSeq COSMIC

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Kaplan plot for NOS1AP in