DegronMD

Uniprot ID: O75052

Source protein: Carboxyl-terminal PDZ ligand of neuronal nitric oxide synthase protein

Source gene: NOS1AP

Class: DEG_SCF_FBW7_2

Location: 391:397

E3 ligase: FBXW7

DEGRON score: 0.996

ASA_SCORE: 80.1714

COIL: 0.923

CONS_SCORE: 0.4767

DSS_SCORE: 0.5505

HELIX: 0.0497

FCONS_SCORE: 1.1475

RIG_SCORE: 0.667

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.G407V	DO229031	LICA	ICGC	PTTPKPE	DEG_SCF_FBW7_2	0.0556
p.A406S	DO50967	LICA	ICGC	PTTPKPE	DEG_SCF_FBW7_2	0.0833
p.H400Y	DO45370	LUAD	ICGC	PTTPKPE	DEG_SCF_FBW7_2	0.25
p.E397D	DO26052	LUAD	ICGC	PTTPKPE	DEG_SCF_FBW7_2	0.6758
p.P386L	DO229456	SKCA	ICGC	PTTPKPE	DEG_SCF_FBW7_2	0.1944
p.S401L	DO37831	SKCM	ICGC	PTTPKPE	DEG_SCF_FBW7_2	0.2222
p.L399M	DO47849	STAD	ICGC	PTTPKPE	DEG_SCF_FBW7_2	0.2778
p.V387M	DO42560	UCEC	ICGC	PTTPKPE	DEG_SCF_FBW7_2	0.2222
p.C389Y	SIDM02015	Colorectal Carcinoma	GDSC	PTTPKPE	DEG_SCF_FBW7_2	0.2778
p.A406V	SIDM00967	Ovarian Carcinoma	GDSC	PTTPKPE	DEG_SCF_FBW7_2	0.0833
p.K395M	SIDM00448	B-Cell Non-Hodgkin's Lymphoma	GDSC	PTTPKPE	DEG_SCF_FBW7_2	0.6951
p.K395M	RC-K8	haematopoietic_and_lymphoid_tissue	COSMIC	PTTPKPE	DEG_SCF_FBW7_2	0.6951
p.P402S	SIDM00839	Colorectal Carcinoma	GDSC	PTTPKPE	DEG_SCF_FBW7_2	0.1944
p.P402S	LoVo	large_intestine	COSMIC	PTTPKPE	DEG_SCF_FBW7_2	0.1944
p.A407V	SNU-1040	large_intestine	COSMIC	PTTPKPE	DEG_SCF_FBW7_2	0.0556
p.K390M	RC-K8	haematopoietic_and_lymphoid_tissue	COSMIC	PTTPKPE	DEG_SCF_FBW7_2	0.3056
p.P397S	LoVo	large_intestine	COSMIC	PTTPKPE	DEG_SCF_FBW7_2	0.6752

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
O75052	Carboxyl-terminal PDZ ligand of neuronal nitric oxide synthase protein	DEG_SCF_FBW7_2	391:397	PTTPKPE	FBXW7	0.996	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons