DegronMD - Q9HCK8(CHD8)

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Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.V175L	TCGA-44-2668	LUAD	TCGA	PPSSS	DEG_SPOP_SBC_1	165:169	Mutation rewiring degron network	0.1667
p.V175L	DO25232	LUAD	ICGC	PPSSS	DEG_SPOP_SBC_1	165:169	Mutation rewiring degron network	0.1667
p.P2212A	TCGA-44-6777	LUAD	TCGA	EYGDSPVPTP	DEG_COP1_1	2207:2216	Mutation altering degron motif	0.6392
p.P2212A	TCGA-44-6777	LUAD	TCGA	PVPTPRSS	DEG_SCF_FBW7_1	2212:2219	Mutation altering degron motif	0.7503
p.S147I	TCGA-55-8506	LUAD	TCGA	AVSSS	DEG_SPOP_SBC_1	142:146	Mutation rewiring degron network	0.3056
p.S147I	DO45390	LUAD	ICGC	AVSSS	DEG_SPOP_SBC_1	142:146	Mutation rewiring degron network	0.3056
p.M2125V	TCGA-5M-AAT6	COAD	TCGA	RSKLYDE	LIG_APCC_ABBAyCdc20_2	2111:2117	Mutation rewiring degron network	0.1111
p.E2029K	TCGA-98-A538	LUSC	TCGA	EETATQVPSL	DEG_COP1_1	2010:2019	Mutation rewiring degron network	0.0556
p.H2028L	TCGA-A2-A25F	BRCA	TCGA	EETATQVPSL	DEG_COP1_1	2010:2019	Mutation rewiring degron network	0.0833
p.H2028L	TCGA-WE-A8ZX	SKCM	TCGA	EETATQVPSL	DEG_COP1_1	2010:2019	Mutation rewiring degron network	0.0833
p.H2028Y	TCGA-A6-2686	COAD	TCGA	EETATQVPSL	DEG_COP1_1	2010:2019	Mutation rewiring degron network	0.0833
p.S2220I	TCGA-AA-3663	COAD	TCGA	PRSSS	DEG_SPOP_SBC_1	2216:2220	Mutation altering degron motif	0.7341
p.L2114F	TCGA-AX-A1CE	UCEC	TCGA	RSKLYDE	LIG_APCC_ABBAyCdc20_2	2111:2117	Mutation altering degron motif	0.6981
p.L2114F	SIDM01134	Small Cell Lung Carcinoma	GDSC	RSKLYDE	LIG_APCC_ABBAyCdc20_2	2111:2117	Mutation altering degron motif	0.6981
p.L2114F	SIDM01986	Non-Small Cell Lung Carcinoma	GDSC	RSKLYDE	LIG_APCC_ABBAyCdc20_2	2111:2117	Mutation altering degron motif	0.6981
p.L2307F	TCGA-BF-AAP4	SKCM	TCGA	NRKKLVELE	DEG_APCC_DBOX_1	2289:2297	Mutation rewiring degron network	0.0556
p.S139C	TCGA-BH-A0B6	BRCA	TCGA	AVSSS	DEG_SPOP_SBC_1	142:146	Mutation rewiring degron network	0.25
p.S139C	DO2641	BRCA	ICGC	AVSSS	DEG_SPOP_SBC_1	142:146	Mutation rewiring degron network	0.25
p.S2223P	TCGA-BR-6452	STAD	TCGA	EYGDSPVPTP	DEG_COP1_1	2207:2216	Mutation blocking phosphorylation signal	0.5833
p.S2223P	TCGA-BR-6452	STAD	TCGA	PVPTPRSS	DEG_SCF_FBW7_1	2212:2219	Mutation blocking phosphorylation signal	0.6667
p.S2223P	TCGA-BR-6452	STAD	TCGA	PRSSS	DEG_SPOP_SBC_1	2216:2220	Mutation blocking phosphorylation signal	0.6944
p.S2211C	TCGA-CV-A45P	HNSC	TCGA	EYGDSPVPTP	DEG_COP1_1	2207:2216	Mutation altering degron motif	0.7541
p.V2016F	TCGA-DF-A2KN	UCEC	TCGA	EETATQVPSL	DEG_COP1_1	2010:2019	Mutation altering degron motif	0.7068
p.E2207G	TCGA-E6-A2P8	UCEC	TCGA	EYGDSPVPTP	DEG_COP1_1	2207:2216	Mutation altering degron motif	0.7199
p.H174Y	TCGA-EB-A3HV	SKCM	TCGA	PPSSS	DEG_SPOP_SBC_1	165:169	Mutation rewiring degron network	0.1944
p.H174Y	DO37647	SKCM	ICGC	PPSSS	DEG_SPOP_SBC_1	165:169	Mutation rewiring degron network	0.1944
p.L2075F	TCGA-EK-A3GK	CESC	TCGA	PSSSS	DEG_SPOP_SBC_1	2080:2084	Mutation rewiring degron network	0.1944
p.G137C	TCGA-ER-A19B	SKCM	TCGA	AVSSS	DEG_SPOP_SBC_1	142:146	Mutation rewiring degron network	0.1944
p.G137C	DO47491	SKCM	ICGC	AVSSS	DEG_SPOP_SBC_1	142:146	Mutation rewiring degron network	0.1944
p.R2420C	TCGA-FI-A2D0	UCEC	TCGA	MRPDLSKMM	DEG_APCC_DBOX_1	2422:2430	Mutation rewiring degron network	0.2778
p.E2072Q	TCGA-LN-A49M	ESCA	TCGA	PSSSS	DEG_SPOP_SBC_1	2080:2084	Mutation rewiring degron network	0.1111
p.P2009S	TCGA-QS-A5YR	UCEC	TCGA	EETATQVPSL	DEG_COP1_1	2010:2019	Mutation rewiring degron network	0.3056
p.L2198V	TCGA-TQ-A8XE	LGG	TCGA	EYGDSPVPTP	DEG_COP1_1	2207:2216	Mutation rewiring degron network	0.0833
p.E2117K	TCGA-W3-AA1V	SKCM	TCGA	RSKLYDE	LIG_APCC_ABBAyCdc20_2	2111:2117	Mutation altering degron motif	0.7022
p.S146I	DO2919	BRCA	ICGC	AVSSS	DEG_SPOP_SBC_1	142:146	Mutation altering degron motif	0.8453
p.P2104L	DO10373	COAD	ICGC	RSKLYDE	LIG_APCC_ABBAyCdc20_2	2111:2117	Mutation rewiring degron network	0.1389
p.P2220H	DO7855	COAD	ICGC	PRSSS	DEG_SPOP_SBC_1	2216:2220	Mutation altering degron motif	0.7694
p.P2220H	DO222842	COCA	ICGC	PRSSS	DEG_SPOP_SBC_1	2216:2220	Mutation altering degron motif	0.7694
p.M2198L	DO8722	COAD	ICGC	EYGDSPVPTP	DEG_COP1_1	2207:2216	Mutation rewiring degron network	0.0833
p.S161L	DO222762	COCA	ICGC	PPSSS	DEG_SPOP_SBC_1	165:169	Mutation rewiring degron network	0.2222
p.P2202L	DO11106	GBM	ICGC	EYGDSPVPTP	DEG_COP1_1	2207:2216	Mutation blocking phosphorylation signal	0.6389
p.P2202L	DO11106	GBM	ICGC	PVPTPRSS	DEG_SCF_FBW7_1	2212:2219	Mutation blocking phosphorylation signal	0.5
p.K158Q	DO228299	LICA	ICGC	PPSSS	DEG_SPOP_SBC_1	165:169	Mutation substituting flanking lysine	0.25
p.A149E	DO229018	LICA	ICGC	AVSSS	DEG_SPOP_SBC_1	142:146	Mutation rewiring degron network	0.25
p.H2206N	DO229027	LICA	ICGC	EYGDSPVPTP	DEG_COP1_1	2207:2216	Mutation rewiring degron network	0.3056
p.H2206N	DO229027	LICA	ICGC	PVPTPRSS	DEG_SCF_FBW7_1	2212:2219	Mutation rewiring degron network	0.1667
p.H2206N	DO229027	LICA	ICGC	PRSSS	DEG_SPOP_SBC_1	2216:2220	Mutation rewiring degron network	0.0556
p.L2017M	DO229037	LICA	ICGC	EETATQVPSL	DEG_COP1_1	2010:2019	Mutation altering degron motif	0.711
p.H2219P	DO223919	LIHC	ICGC	PVPTPRSS	DEG_SCF_FBW7_1	2212:2219	Mutation altering degron motif	0.7694
p.H2219P	DO223919	LIHC	ICGC	PRSSS	DEG_SPOP_SBC_1	2216:2220	Mutation altering degron motif	0.7694
p.H2219P	DO229272	THCA	ICGC	PVPTPRSS	DEG_SCF_FBW7_1	2212:2219	Mutation altering degron motif	0.7694
p.H2219P	DO229272	THCA	ICGC	PRSSS	DEG_SPOP_SBC_1	2216:2220	Mutation altering degron motif	0.7694
p.H2219P	DO229234	THCA	ICGC	PVPTPRSS	DEG_SCF_FBW7_1	2212:2219	Mutation altering degron motif	0.7694
p.H2219P	DO229234	THCA	ICGC	PRSSS	DEG_SPOP_SBC_1	2216:2220	Mutation altering degron motif	0.7694
p.E2023D	DO23214	LINC	ICGC	EETATQVPSL	DEG_COP1_1	2010:2019	Mutation rewiring degron network	0.2222
p.E2023D	DO23506	LINC	ICGC	EETATQVPSL	DEG_COP1_1	2010:2019	Mutation rewiring degron network	0.2222
p.S139A	DO23330	LINC	ICGC	AVSSS	DEG_SPOP_SBC_1	142:146	Mutation rewiring degron network	0.25
p.Q179H	DO224563	LUSC	ICGC	PPSSS	DEG_SPOP_SBC_1	165:169	Mutation rewiring degron network	0.0556
p.K2115R	DO228418	MALY	ICGC	RSKLYDE	LIG_APCC_ABBAyCdc20_2	2111:2117	Mutation altering degron motif	0.7237
p.H2117N	DO228584	MALY	ICGC	RSKLYDE	LIG_APCC_ABBAyCdc20_2	2111:2117	Mutation altering degron motif	0.7423
p.H2218P	DO228593	MALY	ICGC	PVPTPRSS	DEG_SCF_FBW7_1	2212:2219	Mutation altering degron motif	0.7694
p.H2218P	DO228593	MALY	ICGC	PRSSS	DEG_SPOP_SBC_1	2216:2220	Mutation altering degron motif	0.7694
p.R2081C	DO222880	MELA	ICGC	PSSSS	DEG_SPOP_SBC_1	2080:2084	Mutation altering degron motif	0.8301
p.R2081C	DO41584	UCEC	ICGC	PSSSS	DEG_SPOP_SBC_1	2080:2084	Mutation altering degron motif	0.8301
p.R171C	DO33091	PACA	ICGC	PPSSS	DEG_SPOP_SBC_1	165:169	Mutation rewiring degron network	0.2778
p.H2221P	DO227638	PBCA	ICGC	EYGDSPVPTP	DEG_COP1_1	2207:2216	Mutation rewiring degron network	0.1944
p.H2221P	DO227638	PBCA	ICGC	PVPTPRSS	DEG_SCF_FBW7_1	2212:2219	Mutation rewiring degron network	0.2778
p.H2221P	DO227638	PBCA	ICGC	PRSSS	DEG_SPOP_SBC_1	2216:2220	Mutation rewiring degron network	0.3056
p.H2221P	DO48919	PBCA	ICGC	EYGDSPVPTP	DEG_COP1_1	2207:2216	Mutation rewiring degron network	0.1944
p.H2221P	DO48919	PBCA	ICGC	PVPTPRSS	DEG_SCF_FBW7_1	2212:2219	Mutation rewiring degron network	0.2778
p.H2221P	DO48919	PBCA	ICGC	PRSSS	DEG_SPOP_SBC_1	2216:2220	Mutation rewiring degron network	0.3056
p.H2221P	DO229272	THCA	ICGC	EYGDSPVPTP	DEG_COP1_1	2207:2216	Mutation rewiring degron network	0.1944
p.H2221P	DO229272	THCA	ICGC	PVPTPRSS	DEG_SCF_FBW7_1	2212:2219	Mutation rewiring degron network	0.2778
p.H2221P	DO229272	THCA	ICGC	PRSSS	DEG_SPOP_SBC_1	2216:2220	Mutation rewiring degron network	0.3056
p.L2127F	DO46988	RECA	ICGC	RSKLYDE	LIG_APCC_ABBAyCdc20_2	2111:2117	Mutation rewiring degron network	0.0556
p.P134L	DO229459	SKCA	ICGC	AVSSS	DEG_SPOP_SBC_1	142:146	Mutation rewiring degron network	0.1111
p.E168K	DO51294	SKCM	ICGC	PPSSS	DEG_SPOP_SBC_1	165:169	Mutation altering degron motif	0.7022
p.L2028F	DO219468	SKCM	ICGC	EETATQVPSL	DEG_COP1_1	2010:2019	Mutation rewiring degron network	0.0833
p.R171H	DO38723	STAD	ICGC	PPSSS	DEG_SPOP_SBC_1	165:169	Mutation rewiring degron network	0.2778
p.A2076V	DO51761	STAD	ICGC	PSSSS	DEG_SPOP_SBC_1	2080:2084	Mutation blocking phosphorylation signal	0.6667
p.H2226P	DO229221	THCA	ICGC	EYGDSPVPTP	DEG_COP1_1	2207:2216	Mutation rewiring degron network	0.0556
p.H2226P	DO229221	THCA	ICGC	PVPTPRSS	DEG_SCF_FBW7_1	2212:2219	Mutation rewiring degron network	0.1389
p.H2226P	DO229221	THCA	ICGC	PRSSS	DEG_SPOP_SBC_1	2216:2220	Mutation rewiring degron network	0.1667
p.H2221Q	DO229240	THCA	ICGC	EYGDSPVPTP	DEG_COP1_1	2207:2216	Mutation rewiring degron network	0.1944
p.H2221Q	DO229240	THCA	ICGC	PVPTPRSS	DEG_SCF_FBW7_1	2212:2219	Mutation rewiring degron network	0.2778
p.H2221Q	DO229240	THCA	ICGC	PRSSS	DEG_SPOP_SBC_1	2216:2220	Mutation rewiring degron network	0.3056
p.H2224P	DO229250	THCA	ICGC	EYGDSPVPTP	DEG_COP1_1	2207:2216	Mutation rewiring degron network	0.1111
p.H2224P	DO229250	THCA	ICGC	PVPTPRSS	DEG_SCF_FBW7_1	2212:2219	Mutation rewiring degron network	0.1944
p.H2224P	DO229250	THCA	ICGC	PRSSS	DEG_SPOP_SBC_1	2216:2220	Mutation rewiring degron network	0.2222
p.A155V	DO41752	UCEC	ICGC	AVSSS	DEG_SPOP_SBC_1	142:146	Mutation rewiring degron network	0.0833
p.A155V	DO41752	UCEC	ICGC	PPSSS	DEG_SPOP_SBC_1	165:169	Mutation rewiring degron network	0.0556
p.L2075I	DO41903	UCEC	ICGC	PSSSS	DEG_SPOP_SBC_1	2080:2084	Mutation rewiring degron network	0.1944
p.L173W	DO42665	UCEC	ICGC	PPSSS	DEG_SPOP_SBC_1	165:169	Mutation rewiring degron network	0.2222
p.R2111C	SIDM02035	Colorectal Carcinoma	GDSC	RSKLYDE	LIG_APCC_ABBAyCdc20_2	2111:2117	Mutation altering degron motif	0.8301
p.G137V	SIDM00407	B-Cell Non-Hodgkin's Lymphoma	GDSC	AVSSS	DEG_SPOP_SBC_1	142:146	Mutation rewiring degron network	0.1944
p.G137V	ACH-000611	Lymphoma	CCLE	AVSSS	DEG_SPOP_SBC_1	142:146	Mutation rewiring degron network	0.1944
p.G137V	SU-DHL-6	haematopoietic and lymphoid tissue	COSMIC	AVSSS	DEG_SPOP_SBC_1	142:146	Mutation rewiring degron network	0.1944
p.R2000C	SIDM00789	Colorectal Carcinoma	GDSC	EETATQVPSL	DEG_COP1_1	2010:2019	Mutation rewiring degron network	0.0556
p.R2000C	ACH-000997	Colon/Colorectal Cancer	CCLE	EETATQVPSL	DEG_COP1_1	2010:2019	Mutation rewiring degron network	0.0556
p.R2000C	ACH-001061	Colon/Colorectal Cancer	CCLE	EETATQVPSL	DEG_COP1_1	2010:2019	Mutation rewiring degron network	0.0556
p.R2000C	ACH-001091	Colon/Colorectal Cancer	CCLE	EETATQVPSL	DEG_COP1_1	2010:2019	Mutation rewiring degron network	0.0556
p.R2000C	HCT-15	large intestine	COSMIC	EETATQVPSL	DEG_COP1_1	2010:2019	Mutation rewiring degron network	0.0556
p.Y2208D	SIDM01007	T-Lymphoblastic Leukemia	GDSC	EYGDSPVPTP	DEG_COP1_1	2207:2216	Mutation altering degron motif	0.6214
p.Y2208D	ACH-002256	Leukemia	CCLE	EYGDSPVPTP	DEG_COP1_1	2207:2216	Mutation altering degron motif	0.6214
p.Y2208D	KARPAS-45	haematopoietic and lymphoid tissue	COSMIC	EYGDSPVPTP	DEG_COP1_1	2207:2216	Mutation altering degron motif	0.6214
p.M2433V	SIDM00661	B-Cell Non-Hodgkin's Lymphoma	GDSC	MRPDLSKMM	DEG_APCC_DBOX_1	2422:2430	Mutation rewiring degron network	0.25
p.M2433V	ACH-000914	Lymphoma	CCLE	MRPDLSKMM	DEG_APCC_DBOX_1	2422:2430	Mutation rewiring degron network	0.25
p.M2433V	HT	haematopoietic and lymphoid tissue	COSMIC	MRPDLSKMM	DEG_APCC_DBOX_1	2422:2430	Mutation rewiring degron network	0.25
p.Q2434R	SIDM00151	Ovarian Carcinoma	GDSC	MRPDLSKMM	DEG_APCC_DBOX_1	2422:2430	Mutation rewiring degron network	0.2222
p.Q2434R	ACH-000966	Ovarian Cancer	CCLE	MRPDLSKMM	DEG_APCC_DBOX_1	2422:2430	Mutation rewiring degron network	0.2222
p.Q2434R	IGROV-1	ovary	COSMIC	MRPDLSKMM	DEG_APCC_DBOX_1	2422:2430	Mutation rewiring degron network	0.2222
p.E2027K	SIDM00272	Breast Carcinoma	GDSC	EETATQVPSL	DEG_COP1_1	2010:2019	Mutation rewiring degron network	0.1111
p.E2027K	ACH-000910	Breast Cancer	CCLE	EETATQVPSL	DEG_COP1_1	2010:2019	Mutation rewiring degron network	0.1111
p.E2027K	MDA-MB-453	breast	COSMIC	EETATQVPSL	DEG_COP1_1	2010:2019	Mutation rewiring degron network	0.1111
p.S2220G	SIDM00250	Esophageal Squamous Cell Carcinoma	GDSC	PRSSS	DEG_SPOP_SBC_1	2216:2220	Mutation altering degron motif	0.6993
p.S2220G	SIDM00276	Biliary Tract Carcinoma	GDSC	PRSSS	DEG_SPOP_SBC_1	2216:2220	Mutation altering degron motif	0.6993
p.S2220G	ACH-000917	Esophageal Cancer	CCLE	PRSSS	DEG_SPOP_SBC_1	2216:2220	Mutation altering degron motif	0.6993
p.S2220G	ACH-001858	Bile Duct Cancer	CCLE	PRSSS	DEG_SPOP_SBC_1	2216:2220	Mutation altering degron motif	0.6993
p.S2220G	ACH-002237	Bile Duct Cancer	CCLE	PRSSS	DEG_SPOP_SBC_1	2216:2220	Mutation altering degron motif	0.6993
p.S2220G	TE-4	oesophagus	COSMIC	PRSSS	DEG_SPOP_SBC_1	2216:2220	Mutation altering degron motif	0.6993
p.S2220G	ETK-1	biliary tract	COSMIC	PRSSS	DEG_SPOP_SBC_1	2216:2220	Mutation altering degron motif	0.6993
p.P2201S	SIDM00948	Burkitt's Lymphoma	GDSC	EYGDSPVPTP	DEG_COP1_1	2207:2216	Mutation rewiring degron network	0.1667
p.P2201S	ACH-002232	Lymphoma	CCLE	EYGDSPVPTP	DEG_COP1_1	2207:2216	Mutation rewiring degron network	0.1667
p.P2201S	DG-75	haematopoietic and lymphoid tissue	COSMIC	EYGDSPVPTP	DEG_COP1_1	2207:2216	Mutation rewiring degron network	0.1667
p.P2001R	SIDM00861	Ovarian Carcinoma	GDSC	EETATQVPSL	DEG_COP1_1	2010:2019	Mutation rewiring degron network	0.0833
p.P2001R	ES-2	ovary	COSMIC	EETATQVPSL	DEG_COP1_1	2010:2019	Mutation rewiring degron network	0.0833
p.R2000H	SIDM00173	Head and Neck Carcinoma	GDSC	EETATQVPSL	DEG_COP1_1	2010:2019	Mutation rewiring degron network	0.0556
p.R2000H	ACH-000618	Head and Neck Cancer	CCLE	EETATQVPSL	DEG_COP1_1	2010:2019	Mutation rewiring degron network	0.0556
p.P134S	ACH-000278	Ovarian Cancer	CCLE	AVSSS	DEG_SPOP_SBC_1	142:146	Mutation rewiring degron network	0.1111
p.A2229V	ACH-001061	Colon/Colorectal Cancer	CCLE	PVPTPRSS	DEG_SCF_FBW7_1	2212:2219	Mutation rewiring degron network	0.0556
p.A2229V	ACH-001061	Colon/Colorectal Cancer	CCLE	PRSSS	DEG_SPOP_SBC_1	2216:2220	Mutation rewiring degron network	0.0833
p.R2125Q	NCI-H2347	lung	COSMIC	RSKLYDE	LIG_APCC_ABBAyCdc20_2	2111:2117	Mutation rewiring degron network	0.1111
p.P159S	SISO	cervix	COSMIC	PPSSS	DEG_SPOP_SBC_1	165:169	Mutation rewiring degron network	0.1667
p.D2287Y	MDA-MB-361	breast	COSMIC	NRKKLVELE	DEG_APCC_DBOX_1	2289:2297	Mutation rewiring degron network	0.2778

DegronMD: protein-targeted degradation, mutation and drug response to degrons

CHD8

UniProt ID: Q9HCK8

Entrez ID: 57680

Protein name: Chromodomain-helicase-DNA-binding protein 8 (CHD-8) (EC 3.6.4.12) (ATP-dependent helicase CHD8) (Helicase with SNF2 domain 1)

External links: UniprotKB HGNC RefSeq COSMIC

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Kaplan plot for CHD8 in