DegronMD

Uniprot ID: Q9HCK8

Source protein: Chromodomain-helicase-DNA-binding protein 8

Source gene: CHD8

Class: DEG_APCC_DBOX_1

Location: 2422:2430

E3 ligase: APC,CDC20,FZR1

DEGRON score: 0.6839

ASA_SCORE: 86.8444

COIL: 0.5104

CONS_SCORE: 0.3139

DSS_SCORE: 0.6352

HELIX: 0.4788

FCONS_SCORE: 0.9267

RIG_SCORE: 0.7461

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Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.R2420C	TCGA-FI-A2D0	UCEC	TCGA	MRPDLSKMM	DEG_APCC_DBOX_1	0.2778
p.M2433V	SIDM00661	B-Cell Non-Hodgkin's Lymphoma	GDSC	MRPDLSKMM	DEG_APCC_DBOX_1	0.25
p.M2433V	ACH-000914	Lymphoma	CCLE	MRPDLSKMM	DEG_APCC_DBOX_1	0.25
p.M2433V	HT	haematopoietic_and_lymphoid_tissue	COSMIC	MRPDLSKMM	DEG_APCC_DBOX_1	0.25
p.Q2434R	SIDM00151	Ovarian Carcinoma	GDSC	MRPDLSKMM	DEG_APCC_DBOX_1	0.2222
p.Q2434R	ACH-000966	Ovarian Cancer	CCLE	MRPDLSKMM	DEG_APCC_DBOX_1	0.2222
p.Q2434R	IGROV-1	ovary	COSMIC	MRPDLSKMM	DEG_APCC_DBOX_1	0.2222

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Sample	Cancer	Mutation (In Degron?)	Dataset	Drug	IC50
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Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q9HCK8	Chromodomain-helicase-DNA-binding protein 8	DEG_APCC_DBOX_1	2422:2430	MRPDLSKMM	APC,CDC20,FZR1	0.6839	More...

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DegronMD: protein-targeted degradation, mutation and drug response to degrons