DegronMD

Uniprot ID: Q9HCK8

Source protein: Chromodomain-helicase-DNA-binding protein 8

Source gene: CHD8

Class: DEG_SCF_FBW7_1

Location: 2212:2219

E3 ligase: FBXW7

DEGRON score: 0.987

ASA_SCORE: 91.25

COIL: 0.9294

CONS_SCORE: 0.3432

DSS_SCORE: 0.6744

HELIX: 0.0399

FCONS_SCORE: 1.0562

RIG_SCORE: 0.6121

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.P2212A	TCGA-44-6777	LUAD	TCGA	PVPTPRSS	DEG_SCF_FBW7_1	0.7503
p.S2223P	TCGA-BR-6452	STAD	TCGA	PVPTPRSS	DEG_SCF_FBW7_1	0.6667
p.P2202L	DO11106	GBM	ICGC	PVPTPRSS	DEG_SCF_FBW7_1	0.5
p.H2206N	DO229027	LICA	ICGC	PVPTPRSS	DEG_SCF_FBW7_1	0.1667
p.H2219P	DO223919	LIHC	ICGC	PVPTPRSS	DEG_SCF_FBW7_1	0.7694
p.H2219P	DO229272	THCA	ICGC	PVPTPRSS	DEG_SCF_FBW7_1	0.7694
p.H2219P	DO229234	THCA	ICGC	PVPTPRSS	DEG_SCF_FBW7_1	0.7694
p.H2218P	DO228593	MALY	ICGC	PVPTPRSS	DEG_SCF_FBW7_1	0.7694
p.H2221P	DO227638	PBCA	ICGC	PVPTPRSS	DEG_SCF_FBW7_1	0.2778
p.H2221P	DO48919	PBCA	ICGC	PVPTPRSS	DEG_SCF_FBW7_1	0.2778
p.H2221P	DO229272	THCA	ICGC	PVPTPRSS	DEG_SCF_FBW7_1	0.2778
p.H2226P	DO229221	THCA	ICGC	PVPTPRSS	DEG_SCF_FBW7_1	0.1389
p.H2221Q	DO229240	THCA	ICGC	PVPTPRSS	DEG_SCF_FBW7_1	0.2778
p.H2224P	DO229250	THCA	ICGC	PVPTPRSS	DEG_SCF_FBW7_1	0.1944
p.A2229V	ACH-001061	Colon/Colorectal Cancer	CCLE	PVPTPRSS	DEG_SCF_FBW7_1	0.0556

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q9HCK8	Chromodomain-helicase-DNA-binding protein 8	DEG_SCF_FBW7_1	2212:2219	PVPTPRSS	FBXW7	0.987	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons