DegronMD

Uniprot ID: Q9HCK8

Source protein: Chromodomain-helicase-DNA-binding protein 8

Source gene: CHD8

Class: DEG_COP1_1

Location: 2010:2019

E3 ligase: COP1

DEGRON score: 0.9886

ASA_SCORE: 82.97

COIL: 0.6325

CONS_SCORE: 0.3192

DSS_SCORE: 0.6445

HELIX: 0.3352

FCONS_SCORE: 1.0078

RIG_SCORE: 0.6844

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.E2029K	TCGA-98-A538	LUSC	TCGA	EETATQVPSL	DEG_COP1_1	0.0556
p.H2028L	TCGA-A2-A25F	BRCA	TCGA	EETATQVPSL	DEG_COP1_1	0.0833
p.H2028L	TCGA-WE-A8ZX	SKCM	TCGA	EETATQVPSL	DEG_COP1_1	0.0833
p.H2028Y	TCGA-A6-2686	COAD	TCGA	EETATQVPSL	DEG_COP1_1	0.0833
p.V2016F	TCGA-DF-A2KN	UCEC	TCGA	EETATQVPSL	DEG_COP1_1	0.7068
p.P2009S	TCGA-QS-A5YR	UCEC	TCGA	EETATQVPSL	DEG_COP1_1	0.3056
p.L2017M	DO229037	LICA	ICGC	EETATQVPSL	DEG_COP1_1	0.711
p.E2023D	DO23214	LINC	ICGC	EETATQVPSL	DEG_COP1_1	0.2222
p.E2023D	DO23506	LINC	ICGC	EETATQVPSL	DEG_COP1_1	0.2222
p.L2028F	DO219468	SKCM	ICGC	EETATQVPSL	DEG_COP1_1	0.0833
p.R2000C	SIDM00789	Colorectal Carcinoma	GDSC	EETATQVPSL	DEG_COP1_1	0.0556
p.R2000C	ACH-000997	Colon/Colorectal Cancer	CCLE	EETATQVPSL	DEG_COP1_1	0.0556
p.R2000C	ACH-001061	Colon/Colorectal Cancer	CCLE	EETATQVPSL	DEG_COP1_1	0.0556
p.R2000C	ACH-001091	Colon/Colorectal Cancer	CCLE	EETATQVPSL	DEG_COP1_1	0.0556
p.R2000C	HCT-15	large_intestine	COSMIC	EETATQVPSL	DEG_COP1_1	0.0556
p.E2027K	SIDM00272	Breast Carcinoma	GDSC	EETATQVPSL	DEG_COP1_1	0.1111
p.E2027K	ACH-000910	Breast Cancer	CCLE	EETATQVPSL	DEG_COP1_1	0.1111
p.E2027K	MDA-MB-453	breast	COSMIC	EETATQVPSL	DEG_COP1_1	0.1111
p.P2001R	SIDM00861	Ovarian Carcinoma	GDSC	EETATQVPSL	DEG_COP1_1	0.0833
p.P2001R	ES-2	ovary	COSMIC	EETATQVPSL	DEG_COP1_1	0.0833
p.R2000H	SIDM00173	Head and Neck Carcinoma	GDSC	EETATQVPSL	DEG_COP1_1	0.0556
p.R2000H	ACH-000618	Head and Neck Cancer	CCLE	EETATQVPSL	DEG_COP1_1	0.0556

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q9HCK8	Chromodomain-helicase-DNA-binding protein 8	DEG_COP1_1	2010:2019	EETATQVPSL	COP1	0.9886	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons