DegronMD

Uniprot ID: Q9HCK8

Source protein: Chromodomain-helicase-DNA-binding protein 8

Source gene: CHD8

Class: LIG_APCC_ABBAyCdc20_2

Location: 2111:2117

E3 ligase: APC,CDC20,FZR1

DEGRON score: 0.7445

ASA_SCORE: 110.6286

COIL: 0.5309

CONS_SCORE: 0.3126

DSS_SCORE: 0.5558

HELIX: 0.4453

FCONS_SCORE: 0.9253

RIG_SCORE: 0.7138

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.M2125V	TCGA-5M-AAT6	COAD	TCGA	RSKLYDE	LIG_APCC_ABBAyCdc20_2	0.1111
p.L2114F	TCGA-AX-A1CE	UCEC	TCGA	RSKLYDE	LIG_APCC_ABBAyCdc20_2	0.6981
p.L2114F	SIDM01134	Small Cell Lung Carcinoma	GDSC	RSKLYDE	LIG_APCC_ABBAyCdc20_2	0.6981
p.L2114F	SIDM01986	Non-Small Cell Lung Carcinoma	GDSC	RSKLYDE	LIG_APCC_ABBAyCdc20_2	0.6981
p.E2117K	TCGA-W3-AA1V	SKCM	TCGA	RSKLYDE	LIG_APCC_ABBAyCdc20_2	0.7022
p.P2104L	DO10373	COAD	ICGC	RSKLYDE	LIG_APCC_ABBAyCdc20_2	0.1389
p.K2115R	DO228418	MALY	ICGC	RSKLYDE	LIG_APCC_ABBAyCdc20_2	0.7237
p.H2117N	DO228584	MALY	ICGC	RSKLYDE	LIG_APCC_ABBAyCdc20_2	0.7423
p.L2127F	DO46988	RECA	ICGC	RSKLYDE	LIG_APCC_ABBAyCdc20_2	0.0556
p.R2111C	SIDM02035	Colorectal Carcinoma	GDSC	RSKLYDE	LIG_APCC_ABBAyCdc20_2	0.8301
p.R2125Q	NCI-H2347	lung	COSMIC	RSKLYDE	LIG_APCC_ABBAyCdc20_2	0.1111

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q9HCK8	Chromodomain-helicase-DNA-binding protein 8	LIG_APCC_ABBAyCdc20_2	2111:2117	RSKLYDE	APC,CDC20,FZR1	0.7445	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons