DegronMD

Uniprot ID: Q9HCK8

Source protein: Chromodomain-helicase-DNA-binding protein 8

Source gene: CHD8

Class: DEG_COP1_1

Location: 2207:2216

E3 ligase: COP1

DEGRON score: 0.9937

ASA_SCORE: 87.16

COIL: 0.9211

CONS_SCORE: 0.3399

DSS_SCORE: 0.6934

HELIX: 0.0386

FCONS_SCORE: 1.0526

RIG_SCORE: 0.6052

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.P2212A	TCGA-44-6777	LUAD	TCGA	EYGDSPVPTP	DEG_COP1_1	0.6392
p.S2223P	TCGA-BR-6452	STAD	TCGA	EYGDSPVPTP	DEG_COP1_1	0.5833
p.S2211C	TCGA-CV-A45P	HNSC	TCGA	EYGDSPVPTP	DEG_COP1_1	0.7541
p.E2207G	TCGA-E6-A2P8	UCEC	TCGA	EYGDSPVPTP	DEG_COP1_1	0.7199
p.L2198V	TCGA-TQ-A8XE	LGG	TCGA	EYGDSPVPTP	DEG_COP1_1	0.0833
p.M2198L	DO8722	COAD	ICGC	EYGDSPVPTP	DEG_COP1_1	0.0833
p.P2202L	DO11106	GBM	ICGC	EYGDSPVPTP	DEG_COP1_1	0.6389
p.H2206N	DO229027	LICA	ICGC	EYGDSPVPTP	DEG_COP1_1	0.3056
p.H2221P	DO227638	PBCA	ICGC	EYGDSPVPTP	DEG_COP1_1	0.1944
p.H2221P	DO48919	PBCA	ICGC	EYGDSPVPTP	DEG_COP1_1	0.1944
p.H2221P	DO229272	THCA	ICGC	EYGDSPVPTP	DEG_COP1_1	0.1944
p.H2226P	DO229221	THCA	ICGC	EYGDSPVPTP	DEG_COP1_1	0.0556
p.H2221Q	DO229240	THCA	ICGC	EYGDSPVPTP	DEG_COP1_1	0.1944
p.H2224P	DO229250	THCA	ICGC	EYGDSPVPTP	DEG_COP1_1	0.1111
p.Y2208D	SIDM01007	T-Lymphoblastic Leukemia	GDSC	EYGDSPVPTP	DEG_COP1_1	0.6214
p.Y2208D	ACH-002256	Leukemia	CCLE	EYGDSPVPTP	DEG_COP1_1	0.6214
p.Y2208D	KARPAS-45	haematopoietic_and_lymphoid_tissue	COSMIC	EYGDSPVPTP	DEG_COP1_1	0.6214
p.P2201S	SIDM00948	Burkitt's Lymphoma	GDSC	EYGDSPVPTP	DEG_COP1_1	0.1667
p.P2201S	ACH-002232	Lymphoma	CCLE	EYGDSPVPTP	DEG_COP1_1	0.1667
p.P2201S	DG-75	haematopoietic_and_lymphoid_tissue	COSMIC	EYGDSPVPTP	DEG_COP1_1	0.1667

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q9HCK8	Chromodomain-helicase-DNA-binding protein 8	DEG_COP1_1	2207:2216	EYGDSPVPTP	COP1	0.9937	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons