DegronMD: protein-targeted degradation, mutation and drug response to degrons
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BSML
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CGC
Degron:
NRKKLVELE
Uniprot ID:
Q9HCK8
Source protein:
Chromodomain-helicase-DNA-binding protein 8
Source gene:
CHD8
Class:
DEG_APCC_DBOX_1
Location:
2289:2297
E3 ligase:
APC,CDC20,FZR1
DEGRON score:
0.821
ASA_SCORE:
105.1778
COIL:
0.5466
CONS_SCORE:
0.3272
DSS_SCORE:
0.3791
HELIX:
0.4132
FCONS_SCORE:
1.0011
RIG_SCORE:
0.7817
Degron related mutations and impact score
Mutation
Sample
Cancer
Dataset
Degron
Degron class
Impact score
p.L2307F
TCGA-BF-AAP4
SKCM
TCGA
NRKKLVELE
DEG_APCC_DBOX_1
0.0556
p.D2287Y
MDA-MB-361
breast
COSMIC
NRKKLVELE
DEG_APCC_DBOX_1
0.2778
Drug responses associated with CHD8 mutations
Sample
Cancer
Mutation (In Degron?)
Dataset
Drug
IC50
All proteins holding degron of NRKKLVELE
Uniprot ID
Source protein
Degron class
Location
Hit
E3 ligase
Degron score
Detail
Q9HCK8
Chromodomain-helicase-DNA-binding protein 8
DEG_APCC_DBOX_1
2289:2297
NRKKLVELE
APC,CDC20,FZR1
0.821
More...