DegronMD - Q9Y3Q4(HCN4)

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Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.S847Y	TCGA-44-6778	LUAD	TCGA	VDTPSSS	DEG_SCF_FBW7_1	849:855	Mutation rewiring degron network	0.2778
p.S847Y	TCGA-44-6778	LUAD	TCGA	PSSSS	DEG_SPOP_SBC_1	852:856	Mutation rewiring degron network	0.1944
p.S847Y	DO25603	LUAD	ICGC	VDTPSSS	DEG_SCF_FBW7_1	849:855	Mutation rewiring degron network	0.2778
p.S847Y	DO25603	LUAD	ICGC	PSSSS	DEG_SPOP_SBC_1	852:856	Mutation rewiring degron network	0.1944
p.I859M	TCGA-44-8117	LUAD	TCGA	VDTPSSS	DEG_SCF_FBW7_1	849:855	Mutation rewiring degron network	0.2222
p.I859M	TCGA-44-8117	LUAD	TCGA	PSSSS	DEG_SPOP_SBC_1	852:856	Mutation rewiring degron network	0.25
p.I859M	DO24028	LUAD	ICGC	VDTPSSS	DEG_SCF_FBW7_1	849:855	Mutation rewiring degron network	0.2222
p.I859M	DO24028	LUAD	ICGC	PSSSS	DEG_SPOP_SBC_1	852:856	Mutation rewiring degron network	0.25
p.S889A	TCGA-85-8276	LUSC	TCGA	PSSSS	DEG_SPOP_SBC_1	876:880	Mutation rewiring degron network	0.0833
p.S889A	DO26436	LUSC	ICGC	PSSSS	DEG_SPOP_SBC_1	876:880	Mutation rewiring degron network	0.0833
p.P842T	TCGA-91-A4BC	LUAD	TCGA	VDTPSSS	DEG_SCF_FBW7_1	849:855	Mutation rewiring degron network	0.1389
p.P842T	TCGA-91-A4BC	LUAD	TCGA	PSSSS	DEG_SPOP_SBC_1	852:856	Mutation rewiring degron network	0.0556
p.P842T	DO45422	LUAD	ICGC	VDTPSSS	DEG_SCF_FBW7_1	849:855	Mutation rewiring degron network	0.1389
p.P842T	DO45422	LUAD	ICGC	PSSSS	DEG_SPOP_SBC_1	852:856	Mutation rewiring degron network	0.0556
p.A843T	TCGA-AP-A0LM	UCEC	TCGA	VDTPSSS	DEG_SCF_FBW7_1	849:855	Mutation rewiring degron network	0.1667
p.A843T	TCGA-AP-A0LM	UCEC	TCGA	PSSSS	DEG_SPOP_SBC_1	852:856	Mutation rewiring degron network	0.0833
p.A843T	TCGA-AZ-4315	COAD	TCGA	VDTPSSS	DEG_SCF_FBW7_1	849:855	Mutation rewiring degron network	0.1667
p.A843T	TCGA-AZ-4315	COAD	TCGA	PSSSS	DEG_SPOP_SBC_1	852:856	Mutation rewiring degron network	0.0833
p.A843T	TCGA-F1-6177	STAD	TCGA	VDTPSSS	DEG_SCF_FBW7_1	849:855	Mutation rewiring degron network	0.1667
p.A843T	TCGA-F1-6177	STAD	TCGA	PSSSS	DEG_SPOP_SBC_1	852:856	Mutation rewiring degron network	0.0833
p.A843T	DO8842	COAD	ICGC	VDTPSSS	DEG_SCF_FBW7_1	849:855	Mutation rewiring degron network	0.1667
p.A843T	DO8842	COAD	ICGC	PSSSS	DEG_SPOP_SBC_1	852:856	Mutation rewiring degron network	0.0833
p.A843T	DO233944	GACA	ICGC	VDTPSSS	DEG_SCF_FBW7_1	849:855	Mutation rewiring degron network	0.1667
p.A843T	DO233944	GACA	ICGC	PSSSS	DEG_SPOP_SBC_1	852:856	Mutation rewiring degron network	0.0833
p.A843T	DO38727	STAD	ICGC	VDTPSSS	DEG_SCF_FBW7_1	849:855	Mutation rewiring degron network	0.1667
p.A843T	DO38727	STAD	ICGC	PSSSS	DEG_SPOP_SBC_1	852:856	Mutation rewiring degron network	0.0833
p.A843T	DO43306	UCEC	ICGC	VDTPSSS	DEG_SCF_FBW7_1	849:855	Mutation rewiring degron network	0.1667
p.A843T	DO43306	UCEC	ICGC	PSSSS	DEG_SPOP_SBC_1	852:856	Mutation rewiring degron network	0.0833
p.S856F	TCGA-AR-A1AK	BRCA	TCGA	PSSSS	DEG_SPOP_SBC_1	852:856	Mutation altering degron motif	0.7982
p.S856F	DO3846	BRCA	ICGC	PSSSS	DEG_SPOP_SBC_1	852:856	Mutation altering degron motif	0.7982
p.P846L	TCGA-BG-A3EW	UCEC	TCGA	VDTPSSS	DEG_SCF_FBW7_1	849:855	Mutation rewiring degron network	0.25
p.P846L	TCGA-BG-A3EW	UCEC	TCGA	PSSSS	DEG_SPOP_SBC_1	852:856	Mutation rewiring degron network	0.1667
p.P846L	TCGA-BT-A3PH	BLCA	TCGA	VDTPSSS	DEG_SCF_FBW7_1	849:855	Mutation rewiring degron network	0.25
p.P846L	TCGA-BT-A3PH	BLCA	TCGA	PSSSS	DEG_SPOP_SBC_1	852:856	Mutation rewiring degron network	0.1667
p.P846L	DO856	BLCA	ICGC	VDTPSSS	DEG_SCF_FBW7_1	849:855	Mutation rewiring degron network	0.25
p.P846L	DO856	BLCA	ICGC	PSSSS	DEG_SPOP_SBC_1	852:856	Mutation rewiring degron network	0.1667
p.P846L	DO233103	GACA	ICGC	VDTPSSS	DEG_SCF_FBW7_1	849:855	Mutation rewiring degron network	0.25
p.P846L	DO233103	GACA	ICGC	PSSSS	DEG_SPOP_SBC_1	852:856	Mutation rewiring degron network	0.1667
p.P846L	DO48172	UCEC	ICGC	VDTPSSS	DEG_SCF_FBW7_1	849:855	Mutation rewiring degron network	0.25
p.P846L	DO48172	UCEC	ICGC	PSSSS	DEG_SPOP_SBC_1	852:856	Mutation rewiring degron network	0.1667
p.R11Q	TCGA-CK-4951	COAD	TCGA	MRKRLYSLP	DEG_APCC_DBOX_1	8:16	Mutation altering degron motif	0.6218
p.R11Q	DO10582	COAD	ICGC	MRKRLYSLP	DEG_APCC_DBOX_1	8:16	Mutation altering degron motif	0.6218
p.R11Q	ACH-001518	Endometrial/Uterine Cancer	CCLE	MRKRLYSLP	DEG_APCC_DBOX_1	8:16	Mutation altering degron motif	0.6218
p.A867S	TCGA-CV-7427	HNSC	TCGA	PSSSS	DEG_SPOP_SBC_1	876:880	Mutation rewiring degron network	0.0833
p.A867S	DO14286	HNSC	ICGC	PSSSS	DEG_SPOP_SBC_1	876:880	Mutation rewiring degron network	0.0833
p.P890L	TCGA-DU-6402	LGG	TCGA	PSSSS	DEG_SPOP_SBC_1	876:880	Mutation rewiring degron network	0.0556
p.P890L	DO22264	LGG	ICGC	PSSSS	DEG_SPOP_SBC_1	876:880	Mutation rewiring degron network	0.0556
p.P890S	TCGA-DU-6402	LGG	TCGA	PSSSS	DEG_SPOP_SBC_1	876:880	Mutation rewiring degron network	0.0556
p.P890S	DO22264	LGG	ICGC	PSSSS	DEG_SPOP_SBC_1	876:880	Mutation rewiring degron network	0.0556
p.S855Y	TCGA-EE-A2GP	SKCM	TCGA	VDTPSSS	DEG_SCF_FBW7_1	849:855	Mutation altering degron motif	0.712
p.S855Y	TCGA-EE-A2GP	SKCM	TCGA	PSSSS	DEG_SPOP_SBC_1	852:856	Mutation altering degron motif	0.712
p.S855Y	DO37422	SKCM	ICGC	VDTPSSS	DEG_SCF_FBW7_1	849:855	Mutation altering degron motif	0.712
p.S855Y	DO37422	SKCM	ICGC	PSSSS	DEG_SPOP_SBC_1	852:856	Mutation altering degron motif	0.712
p.P846S	TCGA-GF-A6C9	SKCM	TCGA	VDTPSSS	DEG_SCF_FBW7_1	849:855	Mutation rewiring degron network	0.25
p.P846S	TCGA-GF-A6C9	SKCM	TCGA	PSSSS	DEG_SPOP_SBC_1	852:856	Mutation rewiring degron network	0.1667
p.P846S	DO51254	SKCM	ICGC	VDTPSSS	DEG_SCF_FBW7_1	849:855	Mutation rewiring degron network	0.25
p.P846S	DO51254	SKCM	ICGC	PSSSS	DEG_SPOP_SBC_1	852:856	Mutation rewiring degron network	0.1667
p.G870R	TCGA-HZ-8636	PAAD	TCGA	PSSSS	DEG_SPOP_SBC_1	876:880	Mutation rewiring degron network	0.1667
p.G870R	DO32772	PAAD	ICGC	PSSSS	DEG_SPOP_SBC_1	876:880	Mutation rewiring degron network	0.1667
p.A867V	TCGA-K4-A5RJ	BLCA	TCGA	PSSSS	DEG_SPOP_SBC_1	876:880	Mutation rewiring degron network	0.0833
p.A867V	DO49784	BLCA	ICGC	PSSSS	DEG_SPOP_SBC_1	876:880	Mutation rewiring degron network	0.0833
p.A840T	TCGA-VQ-A8P2	STAD	TCGA	VDTPSSS	DEG_SCF_FBW7_1	849:855	Mutation rewiring degron network	0.0833
p.A840T	DO51761	STAD	ICGC	VDTPSSS	DEG_SCF_FBW7_1	849:855	Mutation rewiring degron network	0.0833
p.A840T	SIDM02035	Colorectal Carcinoma	GDSC	VDTPSSS	DEG_SCF_FBW7_1	849:855	Mutation rewiring degron network	0.0833
p.P852L	DO48381	BLCA	ICGC	VDTPSSS	DEG_SCF_FBW7_1	849:855	Mutation altering degron motif	0.7582
p.P852L	DO48381	BLCA	ICGC	PSSSS	DEG_SPOP_SBC_1	852:856	Mutation altering degron motif	0.7582
p.A863T	DO233944	GACA	ICGC	VDTPSSS	DEG_SCF_FBW7_1	849:855	Mutation rewiring degron network	0.1111
p.A863T	DO233944	GACA	ICGC	PSSSS	DEG_SPOP_SBC_1	852:856	Mutation rewiring degron network	0.1389
p.S855F	DO50861	LICA	ICGC	VDTPSSS	DEG_SCF_FBW7_1	849:855	Mutation altering degron motif	0.7982
p.S855F	DO50861	LICA	ICGC	PSSSS	DEG_SPOP_SBC_1	852:856	Mutation altering degron motif	0.7982
p.L100M	DO23122	LINC	ICGC	FRGSLASLG	DEG_APCC_DBOX_1	96:104	Mutation altering degron motif	0.711
p.L100M	DO229259	THCA	ICGC	FRGSLASLG	DEG_APCC_DBOX_1	96:104	Mutation altering degron motif	0.711
p.A886T	DO45299	LIRI	ICGC	PSSSS	DEG_SPOP_SBC_1	876:880	Mutation rewiring degron network	0.1667
p.P882T	DO27943	ORCA	ICGC	PSSSS	DEG_SPOP_SBC_1	876:880	Mutation rewiring degron network	0.2778
p.R106G	DO229232	THCA	ICGC	FRGSLASLG	DEG_APCC_DBOX_1	96:104	Mutation rewiring degron network	0.2778
p.A886V	SIDM00447	B-Lymphoblastic Leukemia	GDSC	PSSSS	DEG_SPOP_SBC_1	876:880	Mutation rewiring degron network	0.1667
p.A886V	SIDM01133	Other Solid Cancers	GDSC	PSSSS	DEG_SPOP_SBC_1	876:880	Mutation rewiring degron network	0.1667
p.P852Q	SIDM01118	Small Cell Lung Carcinoma	GDSC	VDTPSSS	DEG_SCF_FBW7_1	849:855	Mutation altering degron motif	0.7035
p.P852Q	SIDM01118	Small Cell Lung Carcinoma	GDSC	PSSSS	DEG_SPOP_SBC_1	852:856	Mutation altering degron motif	0.7035
p.P852Q	ACH-002175	Lung Cancer	CCLE	VDTPSSS	DEG_SCF_FBW7_1	849:855	Mutation altering degron motif	0.7035
p.P852Q	ACH-002175	Lung Cancer	CCLE	PSSSS	DEG_SPOP_SBC_1	852:856	Mutation altering degron motif	0.7035
p.P852Q	NCI-H740	lung	COSMIC	VDTPSSS	DEG_SCF_FBW7_1	849:855	Mutation altering degron motif	0.7035
p.P852Q	NCI-H740	lung	COSMIC	PSSSS	DEG_SPOP_SBC_1	852:856	Mutation altering degron motif	0.7035
p.V19L	SIDM00926	Non-Small Cell Lung Carcinoma	GDSC	MRKRLYSLP	DEG_APCC_DBOX_1	8:16	Mutation rewiring degron network	0.25
p.P846Q	SIDM01617	Endometrial Carcinoma	GDSC	VDTPSSS	DEG_SCF_FBW7_1	849:855	Mutation rewiring degron network	0.25
p.P846Q	SIDM01617	Endometrial Carcinoma	GDSC	PSSSS	DEG_SPOP_SBC_1	852:856	Mutation rewiring degron network	0.1667
p.P846Q	ACH-000994	Endometrial/Uterine Cancer	CCLE	VDTPSSS	DEG_SCF_FBW7_1	849:855	Mutation rewiring degron network	0.25
p.P846Q	ACH-000994	Endometrial/Uterine Cancer	CCLE	PSSSS	DEG_SPOP_SBC_1	852:856	Mutation rewiring degron network	0.1667
p.G885R	ACH-001061	Colon/Colorectal Cancer	CCLE	PSSSS	DEG_SPOP_SBC_1	876:880	Mutation rewiring degron network	0.1944
p.P882R	ACH-001413	Bladder Cancer	CCLE	PSSSS	DEG_SPOP_SBC_1	876:880	Mutation rewiring degron network	0.2778

DegronMD: protein-targeted degradation, mutation and drug response to degrons

HCN4

UniProt ID: Q9Y3Q4

Entrez ID: 10021

Protein name: Potassium/sodium hyperpolarization-activated cyclic nucleotide-gated channel 4

External links: UniprotKB HGNC RefSeq COSMIC

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Kaplan plot for HCN4 in