DegronMD

Uniprot ID: Q9Y3Q4

Source protein: Potassium/sodium hyperpolarization-activated cyclic nucleotide-gated channel 4

Source gene: HCN4

Class: DEG_SCF_FBW7_1

Location: 849:855

E3 ligase: FBXW7

DEGRON score: 0.9667

ASA_SCORE: 75.1429

COIL: 0.874

CONS_SCORE: 0.2675

DSS_SCORE: 0.6224

HELIX: 0.0894

FCONS_SCORE: 0.8724

RIG_SCORE: 0.5861

Degron related mutations and impact score

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.S847Y	TCGA-44-6778	LUAD	TCGA	VDTPSSS	DEG_SCF_FBW7_1	0.2778
p.S847Y	DO25603	LUAD	ICGC	VDTPSSS	DEG_SCF_FBW7_1	0.2778
p.I859M	TCGA-44-8117	LUAD	TCGA	VDTPSSS	DEG_SCF_FBW7_1	0.2222
p.I859M	DO24028	LUAD	ICGC	VDTPSSS	DEG_SCF_FBW7_1	0.2222
p.P842T	TCGA-91-A4BC	LUAD	TCGA	VDTPSSS	DEG_SCF_FBW7_1	0.1389
p.P842T	DO45422	LUAD	ICGC	VDTPSSS	DEG_SCF_FBW7_1	0.1389
p.A843T	TCGA-AP-A0LM	UCEC	TCGA	VDTPSSS	DEG_SCF_FBW7_1	0.1667
p.A843T	TCGA-AZ-4315	COAD	TCGA	VDTPSSS	DEG_SCF_FBW7_1	0.1667
p.A843T	TCGA-F1-6177	STAD	TCGA	VDTPSSS	DEG_SCF_FBW7_1	0.1667
p.A843T	DO8842	COAD	ICGC	VDTPSSS	DEG_SCF_FBW7_1	0.1667
p.A843T	DO233944	GACA	ICGC	VDTPSSS	DEG_SCF_FBW7_1	0.1667
p.A843T	DO38727	STAD	ICGC	VDTPSSS	DEG_SCF_FBW7_1	0.1667
p.A843T	DO43306	UCEC	ICGC	VDTPSSS	DEG_SCF_FBW7_1	0.1667
p.P846L	TCGA-BG-A3EW	UCEC	TCGA	VDTPSSS	DEG_SCF_FBW7_1	0.25
p.P846L	TCGA-BT-A3PH	BLCA	TCGA	VDTPSSS	DEG_SCF_FBW7_1	0.25
p.P846L	DO856	BLCA	ICGC	VDTPSSS	DEG_SCF_FBW7_1	0.25
p.P846L	DO233103	GACA	ICGC	VDTPSSS	DEG_SCF_FBW7_1	0.25
p.P846L	DO48172	UCEC	ICGC	VDTPSSS	DEG_SCF_FBW7_1	0.25
p.S855Y	TCGA-EE-A2GP	SKCM	TCGA	VDTPSSS	DEG_SCF_FBW7_1	0.712
p.S855Y	DO37422	SKCM	ICGC	VDTPSSS	DEG_SCF_FBW7_1	0.712
p.P846S	TCGA-GF-A6C9	SKCM	TCGA	VDTPSSS	DEG_SCF_FBW7_1	0.25
p.P846S	DO51254	SKCM	ICGC	VDTPSSS	DEG_SCF_FBW7_1	0.25
p.A840T	TCGA-VQ-A8P2	STAD	TCGA	VDTPSSS	DEG_SCF_FBW7_1	0.0833
p.A840T	DO51761	STAD	ICGC	VDTPSSS	DEG_SCF_FBW7_1	0.0833
p.A840T	SIDM02035	Colorectal Carcinoma	GDSC	VDTPSSS	DEG_SCF_FBW7_1	0.0833
p.P852L	DO48381	BLCA	ICGC	VDTPSSS	DEG_SCF_FBW7_1	0.7582
p.A863T	DO233944	GACA	ICGC	VDTPSSS	DEG_SCF_FBW7_1	0.1111
p.S855F	DO50861	LICA	ICGC	VDTPSSS	DEG_SCF_FBW7_1	0.7982
p.P852Q	SIDM01118	Small Cell Lung Carcinoma	GDSC	VDTPSSS	DEG_SCF_FBW7_1	0.7035
p.P852Q	ACH-002175	Lung Cancer	CCLE	VDTPSSS	DEG_SCF_FBW7_1	0.7035
p.P852Q	NCI-H740	lung	COSMIC	VDTPSSS	DEG_SCF_FBW7_1	0.7035
p.P846Q	SIDM01617	Endometrial Carcinoma	GDSC	VDTPSSS	DEG_SCF_FBW7_1	0.25
p.P846Q	ACH-000994	Endometrial/Uterine Cancer	CCLE	VDTPSSS	DEG_SCF_FBW7_1	0.25

DegronMD: protein-targeted degradation, mutation and drug response to degrons

Degron: VDTPSSS

Degron related mutations and impact score

Drug responses associated with HCN4 mutations

All proteins holding degron of VDTPSSS

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q9Y3Q4	Potassium/sodium hyperpolarization-activated cyclic nucleotide-gated channel 4	DEG_SCF_FBW7_1	849:855	VDTPSSS	FBXW7	0.9667	More...