DegronMD

Uniprot ID: Q9Y3Q4

Source protein: Potassium/sodium hyperpolarization-activated cyclic nucleotide-gated channel 4

Source gene: HCN4

Class: DEG_APCC_DBOX_1

Location: 8:16

E3 ligase: APC,CDC20,FZR1

DEGRON score: 0.5595

ASA_SCORE: 85.7889

COIL: 0.5109

CONS_SCORE: 0.3915

DSS_SCORE: 0.4846

HELIX: 0.4576

FCONS_SCORE: 1.0513

RIG_SCORE: 0.749

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.R11Q	TCGA-CK-4951	COAD	TCGA	MRKRLYSLP	DEG_APCC_DBOX_1	0.6218
p.R11Q	DO10582	COAD	ICGC	MRKRLYSLP	DEG_APCC_DBOX_1	0.6218
p.R11Q	ACH-001518	Endometrial/Uterine Cancer	CCLE	MRKRLYSLP	DEG_APCC_DBOX_1	0.6218
p.V19L	SIDM00926	Non-Small Cell Lung Carcinoma	GDSC	MRKRLYSLP	DEG_APCC_DBOX_1	0.25

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q9Y3Q4	Potassium/sodium hyperpolarization-activated cyclic nucleotide-gated channel 4	DEG_APCC_DBOX_1	8:16	MRKRLYSLP	APC,CDC20,FZR1	0.5595	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons