DegronMD

Uniprot ID: Q9Y3Q4

Source protein: Potassium/sodium hyperpolarization-activated cyclic nucleotide-gated channel 4

Source gene: HCN4

Class: DEG_APCC_DBOX_1

Location: 96:104

E3 ligase: APC,CDC20,FZR1

DEGRON score: 0.9832

ASA_SCORE: 72.4556

COIL: 0.7243

CONS_SCORE: 0.3895

DSS_SCORE: 0.5806

HELIX: 0.1482

FCONS_SCORE: 1.0911

RIG_SCORE: 0.6879

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.L100M	DO23122	LINC	ICGC	FRGSLASLG	DEG_APCC_DBOX_1	0.711
p.L100M	DO229259	THCA	ICGC	FRGSLASLG	DEG_APCC_DBOX_1	0.711
p.R106G	DO229232	THCA	ICGC	FRGSLASLG	DEG_APCC_DBOX_1	0.2778

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q9Y3Q4	Potassium/sodium hyperpolarization-activated cyclic nucleotide-gated channel 4	DEG_APCC_DBOX_1	96:104	FRGSLASLG	APC,CDC20,FZR1	0.9832	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons