DegronMD - Q6Q0C0(TRAF7)

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Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.G14W	TCGA-44-6777	LUAD	TCGA	LPTPDVT	DEG_SCF_FBW7_1	19:25	Mutation rewiring degron network	0.1944
p.G14W	DO23645	LUAD	ICGC	LPTPDVT	DEG_SCF_FBW7_1	19:25	Mutation rewiring degron network	0.1944
p.P16T	TCGA-BG-A222	UCEC	TCGA	LPTPDVT	DEG_SCF_FBW7_1	19:25	Mutation rewiring degron network	0.25
p.P16T	DO42977	UCEC	ICGC	LPTPDVT	DEG_SCF_FBW7_1	19:25	Mutation rewiring degron network	0.25
p.D72Y	TCGA-CC-A8HV	LIHC	TCGA	PISTPRRS	DEG_SCF_FBW7_1	79:86	Mutation rewiring degron network	0.1389
p.D72Y	TCGA-CC-A8HV	LIHC	TCGA	PSSSS	DEG_SPOP_SBC_1	60:64	Mutation rewiring degron network	0.1111
p.D72Y	DO229019	LICA	ICGC	PISTPRRS	DEG_SCF_FBW7_1	79:86	Mutation rewiring degron network	0.1389
p.D72Y	DO229019	LICA	ICGC	PSSSS	DEG_SPOP_SBC_1	60:64	Mutation rewiring degron network	0.1111
p.D72Y	DO52189	LIHC	ICGC	PISTPRRS	DEG_SCF_FBW7_1	79:86	Mutation rewiring degron network	0.1389
p.D72Y	DO52189	LIHC	ICGC	PSSSS	DEG_SPOP_SBC_1	60:64	Mutation rewiring degron network	0.1111
p.G35V	TCGA-DX-A8BJ	SARC	TCGA	LPTPDVT	DEG_SCF_FBW7_1	19:25	Mutation rewiring degron network	0.0556
p.G35V	DO220045	SARC	ICGC	LPTPDVT	DEG_SCF_FBW7_1	19:25	Mutation rewiring degron network	0.0556
p.R58K	TCGA-EB-A44O	SKCM	TCGA	PSSSS	DEG_SPOP_SBC_1	60:64	Mutation rewiring degron network	0.2778
p.R58K	DO47272	SKCM	ICGC	PSSSS	DEG_SPOP_SBC_1	60:64	Mutation rewiring degron network	0.2778
p.R11S	TCGA-EE-A3AD	SKCM	TCGA	LPTPDVT	DEG_SCF_FBW7_1	19:25	Mutation rewiring degron network	0.1111
p.R11S	DO37707	SKCM	ICGC	LPTPDVT	DEG_SCF_FBW7_1	19:25	Mutation rewiring degron network	0.1111
p.E31A	TCGA-K7-AAU7	LIHC	TCGA	LPTPDVT	DEG_SCF_FBW7_1	19:25	Mutation rewiring degron network	0.1667
p.E31A	DO219579	LIHC	ICGC	LPTPDVT	DEG_SCF_FBW7_1	19:25	Mutation rewiring degron network	0.1667
p.D87N	TCGA-WE-A8K6	SKCM	TCGA	PISTPRRS	DEG_SCF_FBW7_1	79:86	Mutation rewiring degron network	0.3056
p.D87N	DO51283	SKCM	ICGC	PISTPRRS	DEG_SCF_FBW7_1	79:86	Mutation rewiring degron network	0.3056
p.V24I	DO230347	COCA	ICGC	LPTPDVT	DEG_SCF_FBW7_1	19:25	Mutation altering degron motif	0.5965
p.R11H	DO233903	GACA	ICGC	LPTPDVT	DEG_SCF_FBW7_1	19:25	Mutation rewiring degron network	0.1111
p.R11H	DO232761	PBCA	ICGC	LPTPDVT	DEG_SCF_FBW7_1	19:25	Mutation rewiring degron network	0.1111
p.E74D	DO228986	LICA	ICGC	PISTPRRS	DEG_SCF_FBW7_1	79:86	Mutation rewiring degron network	0.1944
p.E74D	DO228986	LICA	ICGC	PSSSS	DEG_SPOP_SBC_1	60:64	Mutation rewiring degron network	0.0556
p.Q55H	DO50955	LICA	ICGC	PSSSS	DEG_SPOP_SBC_1	60:64	Mutation rewiring degron network	0.1944
p.H56N	DO50955	LICA	ICGC	PSSSS	DEG_SPOP_SBC_1	60:64	Mutation rewiring degron network	0.2222
p.R29G	DO231191	LUSC	ICGC	LPTPDVT	DEG_SCF_FBW7_1	19:25	Mutation rewiring degron network	0.2222
p.R29G	SIDM00352	Ovarian Carcinoma	GDSC	LPTPDVT	DEG_SCF_FBW7_1	19:25	Mutation rewiring degron network	0.2222
p.R29G	SIDM00491	Thyroid Gland Carcinoma	GDSC	LPTPDVT	DEG_SCF_FBW7_1	19:25	Mutation rewiring degron network	0.2222
p.R29G	SIDM01030	Esophageal Squamous Cell Carcinoma	GDSC	LPTPDVT	DEG_SCF_FBW7_1	19:25	Mutation rewiring degron network	0.2222
p.R29G	SIDM00282	Colorectal Carcinoma	GDSC	LPTPDVT	DEG_SCF_FBW7_1	19:25	Mutation rewiring degron network	0.2222
p.R29G	SIDM01180	Hepatocellular Carcinoma	GDSC	LPTPDVT	DEG_SCF_FBW7_1	19:25	Mutation rewiring degron network	0.2222
p.R29G	SIDM00361	Non-Small Cell Lung Carcinoma	GDSC	LPTPDVT	DEG_SCF_FBW7_1	19:25	Mutation rewiring degron network	0.2222
p.R29G	SIDM01031	Esophageal Squamous Cell Carcinoma	GDSC	LPTPDVT	DEG_SCF_FBW7_1	19:25	Mutation rewiring degron network	0.2222
p.R29G	SIDM00359	Colorectal Carcinoma	GDSC	LPTPDVT	DEG_SCF_FBW7_1	19:25	Mutation rewiring degron network	0.2222
p.R29G	SIDM01439	Hepatocellular Carcinoma	GDSC	LPTPDVT	DEG_SCF_FBW7_1	19:25	Mutation rewiring degron network	0.2222
p.R29G	SIDM00165	Other Solid Cancers	GDSC	LPTPDVT	DEG_SCF_FBW7_1	19:25	Mutation rewiring degron network	0.2222
p.R29G	SIDM01335	Kidney Carcinoma	GDSC	LPTPDVT	DEG_SCF_FBW7_1	19:25	Mutation rewiring degron network	0.2222
p.R29G	SIDM01770	Gastric Carcinoma	GDSC	LPTPDVT	DEG_SCF_FBW7_1	19:25	Mutation rewiring degron network	0.2222
p.R29G	SIDM00159	Biliary Tract Carcinoma	GDSC	LPTPDVT	DEG_SCF_FBW7_1	19:25	Mutation rewiring degron network	0.2222
p.G35R	DO222843	MELA	ICGC	LPTPDVT	DEG_SCF_FBW7_1	19:25	Mutation rewiring degron network	0.0556
p.G35R	SIDM02028	Esophageal Carcinoma	GDSC	LPTPDVT	DEG_SCF_FBW7_1	19:25	Mutation rewiring degron network	0.0556
p.T59S	DO229216	THCA	ICGC	PSSSS	DEG_SPOP_SBC_1	60:64	Mutation blocking phosphorylation signal	0.75
p.H56Y	DO229245	THCA	ICGC	PSSSS	DEG_SPOP_SBC_1	60:64	Mutation rewiring degron network	0.2222
p.R71W	SIDM01016	T-Lymphoblastic Leukemia	GDSC	PISTPRRS	DEG_SCF_FBW7_1	79:86	Mutation rewiring degron network	0.1111
p.R71W	SIDM01016	T-Lymphoblastic Leukemia	GDSC	PSSSS	DEG_SPOP_SBC_1	60:64	Mutation rewiring degron network	0.1389
p.R71W	ACH-000995	Leukemia	CCLE	PISTPRRS	DEG_SCF_FBW7_1	79:86	Mutation rewiring degron network	0.1111
p.R71W	ACH-000995	Leukemia	CCLE	PSSSS	DEG_SPOP_SBC_1	60:64	Mutation rewiring degron network	0.1389
p.R71W	Jurkat	haematopoietic and lymphoid tissue	COSMIC	PISTPRRS	DEG_SCF_FBW7_1	79:86	Mutation rewiring degron network	0.1111
p.R71W	Jurkat	haematopoietic and lymphoid tissue	COSMIC	PSSSS	DEG_SPOP_SBC_1	60:64	Mutation rewiring degron network	0.1389
p.P79S	SIDM00333	Endometrial Carcinoma	GDSC	PISTPRRS	DEG_SCF_FBW7_1	79:86	Mutation altering degron motif	0.6752
p.P79S	ACH-000988	Endometrial/Uterine Cancer	CCLE	PISTPRRS	DEG_SCF_FBW7_1	79:86	Mutation altering degron motif	0.6752
p.P79S	MFE-319	endometrium	COSMIC	PISTPRRS	DEG_SCF_FBW7_1	79:86	Mutation altering degron motif	0.6752
p.R93H	SIDM00429	B-Lymphoblastic Leukemia	GDSC	PISTPRRS	DEG_SCF_FBW7_1	79:86	Mutation rewiring degron network	0.1389
p.R93H	ACH-000938	Leukemia	CCLE	PISTPRRS	DEG_SCF_FBW7_1	79:86	Mutation rewiring degron network	0.1389
p.R93H	NALM-6	haematopoietic and lymphoid tissue	COSMIC	PISTPRRS	DEG_SCF_FBW7_1	79:86	Mutation rewiring degron network	0.1389
p.I90F	SIDM00685	Glioblastoma	GDSC	PISTPRRS	DEG_SCF_FBW7_1	79:86	Mutation rewiring degron network	0.2222
p.I90F	ACH-000819	Brain Cancer	CCLE	PISTPRRS	DEG_SCF_FBW7_1	79:86	Mutation rewiring degron network	0.2222
p.I90F	LN-18	central nervous system	COSMIC	PISTPRRS	DEG_SCF_FBW7_1	79:86	Mutation rewiring degron network	0.2222
p.R84H	SIDM00217	Colorectal Carcinoma	GDSC	PISTPRRS	DEG_SCF_FBW7_1	79:86	Mutation altering degron motif	0.7133
p.R84H	ACH-000999	Colon/Colorectal Cancer	CCLE	PISTPRRS	DEG_SCF_FBW7_1	79:86	Mutation altering degron motif	0.7133
p.R84H	SNU-1040	large intestine	COSMIC	PISTPRRS	DEG_SCF_FBW7_1	79:86	Mutation altering degron motif	0.7133
p.R85C	SIDM00312	Plasma Cell Myeloma	GDSC	PISTPRRS	DEG_SCF_FBW7_1	79:86	Mutation altering degron motif	0.719
p.R85C	ACH-000183	Myeloma	CCLE	PISTPRRS	DEG_SCF_FBW7_1	79:86	Mutation altering degron motif	0.719
p.R85C	L-363	haematopoietic and lymphoid tissue	COSMIC	PISTPRRS	DEG_SCF_FBW7_1	79:86	Mutation altering degron motif	0.719
p.Y9H	ACH-000978	Endometrial/Uterine Cancer	CCLE	LPTPDVT	DEG_SCF_FBW7_1	19:25	Mutation blocking phosphorylation signal	0.5
p.Y9H	EN	endometrium	COSMIC	LPTPDVT	DEG_SCF_FBW7_1	19:25	Mutation blocking phosphorylation signal	0.5
p.S86F	ACH-000983	Leukemia	CCLE	PISTPRRS	DEG_SCF_FBW7_1	79:86	Mutation altering degron motif	0.9093
p.P82S	RC-K8	haematopoietic and lymphoid tissue	COSMIC	PISTPRRS	DEG_SCF_FBW7_1	79:86	Mutation altering degron motif	0.6752
p.L32I	MOLT-4	haematopoietic and lymphoid tissue	COSMIC	LPTPDVT	DEG_SCF_FBW7_1	19:25	Mutation rewiring degron network	0.1389

DegronMD: protein-targeted degradation, mutation and drug response to degrons

TRAF7

UniProt ID: Q6Q0C0

Entrez ID: 84231

Protein name: E3 ubiquitin-protein ligase TRAF7 (EC 2.3.2.27) (RING finger and WD repeat-containing protein 1) (RING finger protein 119) (RING-type E3 ubiquitin transferase TRAF7) (TNF receptor-associated factor 7)

External links: UniprotKB HGNC RefSeq COSMIC

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Kaplan plot for TRAF7 in