DegronMD

Uniprot ID: Q6Q0C0

Source protein: E3 ubiquitin-protein ligase TRAF7

Source gene: TRAF7

Class: DEG_SCF_FBW7_1

Location: 79:86

E3 ligase: FBXW7

DEGRON score: 0.9191

ASA_SCORE: 86.225

COIL: 0.9106

CONS_SCORE: 0.2361

DSS_SCORE: 0.6793

HELIX: 0.0383

FCONS_SCORE: 0.8126

RIG_SCORE: 0.6227

Degron related mutations and impact score

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.D72Y	TCGA-CC-A8HV	LIHC	TCGA	PISTPRRS	DEG_SCF_FBW7_1	0.1389
p.D72Y	DO229019	LICA	ICGC	PISTPRRS	DEG_SCF_FBW7_1	0.1389
p.D72Y	DO52189	LIHC	ICGC	PISTPRRS	DEG_SCF_FBW7_1	0.1389
p.D87N	TCGA-WE-A8K6	SKCM	TCGA	PISTPRRS	DEG_SCF_FBW7_1	0.3056
p.D87N	DO51283	SKCM	ICGC	PISTPRRS	DEG_SCF_FBW7_1	0.3056
p.E74D	DO228986	LICA	ICGC	PISTPRRS	DEG_SCF_FBW7_1	0.1944
p.R71W	SIDM01016	T-Lymphoblastic Leukemia	GDSC	PISTPRRS	DEG_SCF_FBW7_1	0.1111
p.R71W	ACH-000995	Leukemia	CCLE	PISTPRRS	DEG_SCF_FBW7_1	0.1111
p.R71W	Jurkat	haematopoietic_and_lymphoid_tissue	COSMIC	PISTPRRS	DEG_SCF_FBW7_1	0.1111
p.P79S	SIDM00333	Endometrial Carcinoma	GDSC	PISTPRRS	DEG_SCF_FBW7_1	0.6752
p.P79S	ACH-000988	Endometrial/Uterine Cancer	CCLE	PISTPRRS	DEG_SCF_FBW7_1	0.6752
p.P79S	MFE-319	endometrium	COSMIC	PISTPRRS	DEG_SCF_FBW7_1	0.6752
p.R93H	SIDM00429	B-Lymphoblastic Leukemia	GDSC	PISTPRRS	DEG_SCF_FBW7_1	0.1389
p.R93H	ACH-000938	Leukemia	CCLE	PISTPRRS	DEG_SCF_FBW7_1	0.1389
p.R93H	NALM-6	haematopoietic_and_lymphoid_tissue	COSMIC	PISTPRRS	DEG_SCF_FBW7_1	0.1389
p.I90F	SIDM00685	Glioblastoma	GDSC	PISTPRRS	DEG_SCF_FBW7_1	0.2222
p.I90F	ACH-000819	Brain Cancer	CCLE	PISTPRRS	DEG_SCF_FBW7_1	0.2222
p.I90F	LN-18	central_nervous_system	COSMIC	PISTPRRS	DEG_SCF_FBW7_1	0.2222
p.R84H	SIDM00217	Colorectal Carcinoma	GDSC	PISTPRRS	DEG_SCF_FBW7_1	0.7133
p.R84H	ACH-000999	Colon/Colorectal Cancer	CCLE	PISTPRRS	DEG_SCF_FBW7_1	0.7133
p.R84H	SNU-1040	large_intestine	COSMIC	PISTPRRS	DEG_SCF_FBW7_1	0.7133
p.R85C	SIDM00312	Plasma Cell Myeloma	GDSC	PISTPRRS	DEG_SCF_FBW7_1	0.719
p.R85C	ACH-000183	Myeloma	CCLE	PISTPRRS	DEG_SCF_FBW7_1	0.719
p.R85C	L-363	haematopoietic_and_lymphoid_tissue	COSMIC	PISTPRRS	DEG_SCF_FBW7_1	0.719
p.S86F	ACH-000983	Leukemia	CCLE	PISTPRRS	DEG_SCF_FBW7_1	0.9093
p.P82S	RC-K8	haematopoietic_and_lymphoid_tissue	COSMIC	PISTPRRS	DEG_SCF_FBW7_1	0.6752

DegronMD: protein-targeted degradation, mutation and drug response to degrons

Degron: PISTPRRS

Degron related mutations and impact score

Drug responses associated with TRAF7 mutations

All proteins holding degron of PISTPRRS

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q6Q0C0	E3 ubiquitin-protein ligase TRAF7	DEG_SCF_FBW7_1	79:86	PISTPRRS	FBXW7	0.9191	More...