DegronMD

Uniprot ID: Q6Q0C0

Source protein: E3 ubiquitin-protein ligase TRAF7

Source gene: TRAF7

Class: DEG_SCF_FBW7_1

Location: 19:25

E3 ligase: FBXW7

DEGRON score: 0.9961

ASA_SCORE: 72.9714

COIL: 0.8157

CONS_SCORE: 0.2809

DSS_SCORE: 0.6189

HELIX: 0.0704

FCONS_SCORE: 0.868

RIG_SCORE: 0.6847

Degron related mutations and impact score

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.G14W	TCGA-44-6777	LUAD	TCGA	LPTPDVT	DEG_SCF_FBW7_1	0.1944
p.G14W	DO23645	LUAD	ICGC	LPTPDVT	DEG_SCF_FBW7_1	0.1944
p.P16T	TCGA-BG-A222	UCEC	TCGA	LPTPDVT	DEG_SCF_FBW7_1	0.25
p.P16T	DO42977	UCEC	ICGC	LPTPDVT	DEG_SCF_FBW7_1	0.25
p.G35V	TCGA-DX-A8BJ	SARC	TCGA	LPTPDVT	DEG_SCF_FBW7_1	0.0556
p.G35V	DO220045	SARC	ICGC	LPTPDVT	DEG_SCF_FBW7_1	0.0556
p.R11S	TCGA-EE-A3AD	SKCM	TCGA	LPTPDVT	DEG_SCF_FBW7_1	0.1111
p.R11S	DO37707	SKCM	ICGC	LPTPDVT	DEG_SCF_FBW7_1	0.1111
p.E31A	TCGA-K7-AAU7	LIHC	TCGA	LPTPDVT	DEG_SCF_FBW7_1	0.1667
p.E31A	DO219579	LIHC	ICGC	LPTPDVT	DEG_SCF_FBW7_1	0.1667
p.V24I	DO230347	COCA	ICGC	LPTPDVT	DEG_SCF_FBW7_1	0.5965
p.R11H	DO233903	GACA	ICGC	LPTPDVT	DEG_SCF_FBW7_1	0.1111
p.R11H	DO232761	PBCA	ICGC	LPTPDVT	DEG_SCF_FBW7_1	0.1111
p.R29G	DO231191	LUSC	ICGC	LPTPDVT	DEG_SCF_FBW7_1	0.2222
p.R29G	SIDM00352	Ovarian Carcinoma	GDSC	LPTPDVT	DEG_SCF_FBW7_1	0.2222
p.R29G	SIDM00491	Thyroid Gland Carcinoma	GDSC	LPTPDVT	DEG_SCF_FBW7_1	0.2222
p.R29G	SIDM01030	Esophageal Squamous Cell Carcinoma	GDSC	LPTPDVT	DEG_SCF_FBW7_1	0.2222
p.R29G	SIDM00282	Colorectal Carcinoma	GDSC	LPTPDVT	DEG_SCF_FBW7_1	0.2222
p.R29G	SIDM01180	Hepatocellular Carcinoma	GDSC	LPTPDVT	DEG_SCF_FBW7_1	0.2222
p.R29G	SIDM00361	Non-Small Cell Lung Carcinoma	GDSC	LPTPDVT	DEG_SCF_FBW7_1	0.2222
p.R29G	SIDM01031	Esophageal Squamous Cell Carcinoma	GDSC	LPTPDVT	DEG_SCF_FBW7_1	0.2222
p.R29G	SIDM00359	Colorectal Carcinoma	GDSC	LPTPDVT	DEG_SCF_FBW7_1	0.2222
p.R29G	SIDM01439	Hepatocellular Carcinoma	GDSC	LPTPDVT	DEG_SCF_FBW7_1	0.2222
p.R29G	SIDM00165	Other Solid Cancers	GDSC	LPTPDVT	DEG_SCF_FBW7_1	0.2222
p.R29G	SIDM01335	Kidney Carcinoma	GDSC	LPTPDVT	DEG_SCF_FBW7_1	0.2222
p.R29G	SIDM01770	Gastric Carcinoma	GDSC	LPTPDVT	DEG_SCF_FBW7_1	0.2222
p.R29G	SIDM00159	Biliary Tract Carcinoma	GDSC	LPTPDVT	DEG_SCF_FBW7_1	0.2222
p.G35R	DO222843	MELA	ICGC	LPTPDVT	DEG_SCF_FBW7_1	0.0556
p.G35R	SIDM02028	Esophageal Carcinoma	GDSC	LPTPDVT	DEG_SCF_FBW7_1	0.0556
p.Y9H	ACH-000978	Endometrial/Uterine Cancer	CCLE	LPTPDVT	DEG_SCF_FBW7_1	0.5
p.Y9H	EN	endometrium	COSMIC	LPTPDVT	DEG_SCF_FBW7_1	0.5
p.L32I	MOLT-4	haematopoietic_and_lymphoid_tissue	COSMIC	LPTPDVT	DEG_SCF_FBW7_1	0.1389

DegronMD: protein-targeted degradation, mutation and drug response to degrons

Degron: LPTPDVT

Degron related mutations and impact score

Drug responses associated with TRAF7 mutations

All proteins holding degron of LPTPDVT

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q6Q0C0	E3 ubiquitin-protein ligase TRAF7	DEG_SCF_FBW7_1	19:25	LPTPDVT	FBXW7	0.9961	More...