DegronMD - Q4G0A6(MINDY4)

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Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.P169L	SIDM00499	Prostate Carcinoma	GDSC	PGETPVLT	DEG_SCF_FBW7_1	169:176	Mutation altering degron motif	0.6471
p.R246W	SIDM01265	Plasma Cell Myeloma	GDSC	EESRKVPEL	DEG_COP1_1	243:251	Mutation altering degron motif	0.7523
p.R246W	SIDM00336	Melanoma	GDSC	EESRKVPEL	DEG_COP1_1	243:251	Mutation altering degron motif	0.7523
p.R246W	SIDM00052	Esophageal Squamous Cell Carcinoma	GDSC	EESRKVPEL	DEG_COP1_1	243:251	Mutation altering degron motif	0.7523
p.R246W	SIDM00721	Small Cell Lung Carcinoma	GDSC	EESRKVPEL	DEG_COP1_1	243:251	Mutation altering degron motif	0.7523
p.Y228C	SIDM00198	Ewing's Sarcoma	GDSC	PSSSS	DEG_SPOP_SBC_1	234:238	Mutation rewiring degron network	0.1667
p.L260P	SIDM01126	Small Cell Lung Carcinoma	GDSC	SRTSLGQLS	DEG_APCC_DBOX_1	268:276	Mutation rewiring degron network	0.1111
p.L260P	SIDM01126	Small Cell Lung Carcinoma	GDSC	EESRKVPEL	DEG_COP1_1	243:251	Mutation rewiring degron network	0.0833
p.L260P	SIDM00746	Non-Small Cell Lung Carcinoma	GDSC	SRTSLGQLS	DEG_APCC_DBOX_1	268:276	Mutation rewiring degron network	0.1111
p.L260P	SIDM00746	Non-Small Cell Lung Carcinoma	GDSC	EESRKVPEL	DEG_COP1_1	243:251	Mutation rewiring degron network	0.0833
p.L260P	SIDM00210	Ovarian Carcinoma	GDSC	SRTSLGQLS	DEG_APCC_DBOX_1	268:276	Mutation rewiring degron network	0.1111
p.L260P	SIDM00210	Ovarian Carcinoma	GDSC	EESRKVPEL	DEG_COP1_1	243:251	Mutation rewiring degron network	0.0833
p.L260P	SIDM00114	Non-Small Cell Lung Carcinoma	GDSC	SRTSLGQLS	DEG_APCC_DBOX_1	268:276	Mutation rewiring degron network	0.1111
p.L260P	SIDM00114	Non-Small Cell Lung Carcinoma	GDSC	EESRKVPEL	DEG_COP1_1	243:251	Mutation rewiring degron network	0.0833
p.L260P	SIDM00539	Esophageal Carcinoma	GDSC	SRTSLGQLS	DEG_APCC_DBOX_1	268:276	Mutation rewiring degron network	0.1111
p.L260P	SIDM00539	Esophageal Carcinoma	GDSC	EESRKVPEL	DEG_COP1_1	243:251	Mutation rewiring degron network	0.0833
p.L260P	SIDM00068	Colorectal Carcinoma	GDSC	SRTSLGQLS	DEG_APCC_DBOX_1	268:276	Mutation rewiring degron network	0.1111
p.L260P	SIDM00068	Colorectal Carcinoma	GDSC	EESRKVPEL	DEG_COP1_1	243:251	Mutation rewiring degron network	0.0833
p.L260P	SIDM00720	Mesothelioma	GDSC	SRTSLGQLS	DEG_APCC_DBOX_1	268:276	Mutation rewiring degron network	0.1111
p.L260P	SIDM00720	Mesothelioma	GDSC	EESRKVPEL	DEG_COP1_1	243:251	Mutation rewiring degron network	0.0833
p.L260P	SIDM01710	Squamous Cell Lung Carcinoma	GDSC	SRTSLGQLS	DEG_APCC_DBOX_1	268:276	Mutation rewiring degron network	0.1111
p.L260P	SIDM01710	Squamous Cell Lung Carcinoma	GDSC	EESRKVPEL	DEG_COP1_1	243:251	Mutation rewiring degron network	0.0833
p.L260P	SIDM01525	Acute Myeloid Leukemia	GDSC	SRTSLGQLS	DEG_APCC_DBOX_1	268:276	Mutation rewiring degron network	0.1111
p.L260P	SIDM01525	Acute Myeloid Leukemia	GDSC	EESRKVPEL	DEG_COP1_1	243:251	Mutation rewiring degron network	0.0833
p.T167M	SIDM01446	Glioblastoma	GDSC	PGETPVLT	DEG_SCF_FBW7_1	169:176	Mutation blocking phosphorylation signal	0.7222
p.Y228H	SIDM00500	Colorectal Carcinoma	GDSC	PSSSS	DEG_SPOP_SBC_1	234:238	Mutation rewiring degron network	0.1667

DegronMD: protein-targeted degradation, mutation and drug response to degrons

MINDY4

UniProt ID: Q4G0A6

Entrez ID: 84182

Protein name: Probable ubiquitin carboxyl-terminal hydrolase MINDY-4 (EC 3.4.19.12) (Probable deubiquitinating enzyme MINDY-4)

External links: UniprotKB HGNC RefSeq COSMIC

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Kaplan plot for MINDY4 in