DegronMD

Uniprot ID: Q4G0A6

Source protein: Probable ubiquitin carboxyl-terminal hydrolase MINDY-4

Source gene: MINDY4

Class: DEG_COP1_1

Location: 243:251

E3 ligase: COP1

DEGRON score: 0.6883

ASA_SCORE: 97.0667

COIL: 0.6689

CONS_SCORE: 0.2713

DSS_SCORE: 0.5939

HELIX: 0.3036

FCONS_SCORE: 0.9352

RIG_SCORE: 0.704

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.R246W	SIDM01265	Plasma Cell Myeloma	GDSC	EESRKVPEL	DEG_COP1_1	0.7523
p.R246W	SIDM00336	Melanoma	GDSC	EESRKVPEL	DEG_COP1_1	0.7523
p.R246W	SIDM00052	Esophageal Squamous Cell Carcinoma	GDSC	EESRKVPEL	DEG_COP1_1	0.7523
p.R246W	SIDM00721	Small Cell Lung Carcinoma	GDSC	EESRKVPEL	DEG_COP1_1	0.7523
p.L260P	SIDM01126	Small Cell Lung Carcinoma	GDSC	EESRKVPEL	DEG_COP1_1	0.0833
p.L260P	SIDM00746	Non-Small Cell Lung Carcinoma	GDSC	EESRKVPEL	DEG_COP1_1	0.0833
p.L260P	SIDM00210	Ovarian Carcinoma	GDSC	EESRKVPEL	DEG_COP1_1	0.0833
p.L260P	SIDM00114	Non-Small Cell Lung Carcinoma	GDSC	EESRKVPEL	DEG_COP1_1	0.0833
p.L260P	SIDM00539	Esophageal Carcinoma	GDSC	EESRKVPEL	DEG_COP1_1	0.0833
p.L260P	SIDM00068	Colorectal Carcinoma	GDSC	EESRKVPEL	DEG_COP1_1	0.0833
p.L260P	SIDM00720	Mesothelioma	GDSC	EESRKVPEL	DEG_COP1_1	0.0833
p.L260P	SIDM01710	Squamous Cell Lung Carcinoma	GDSC	EESRKVPEL	DEG_COP1_1	0.0833
p.L260P	SIDM01525	Acute Myeloid Leukemia	GDSC	EESRKVPEL	DEG_COP1_1	0.0833

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q4G0A6	Probable ubiquitin carboxyl-terminal hydrolase MINDY-4	DEG_COP1_1	243:251	EESRKVPEL	COP1	0.6883	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons