DegronMD: protein-targeted degradation, mutation and drug response to degrons
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BSML
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CGC
Degron:
PGETPVLT
Uniprot ID:
Q4G0A6
Source protein:
Probable ubiquitin carboxyl-terminal hydrolase MINDY-4
Source gene:
MINDY4
Class:
DEG_SCF_FBW7_1
Location:
169:176
E3 ligase:
FBXW7
DEGRON score:
0.9822
ASA_SCORE:
82.1625
COIL:
0.8988
CONS_SCORE:
0.2393
DSS_SCORE:
0.5622
HELIX:
0.0401
FCONS_SCORE:
0.8817
RIG_SCORE:
0.7054
Degron related mutations and impact score
Mutation
Sample
Cancer
Dataset
Degron
Degron class
Impact score
p.P169L
SIDM00499
Prostate Carcinoma
GDSC
PGETPVLT
DEG_SCF_FBW7_1
0.6471
p.T167M
SIDM01446
Glioblastoma
GDSC
PGETPVLT
DEG_SCF_FBW7_1
0.7222
Drug responses associated with MINDY4 mutations
Sample
Cancer
Mutation (In Degron?)
Dataset
Drug
IC50
All proteins holding degron of PGETPVLT
Uniprot ID
Source protein
Degron class
Location
Hit
E3 ligase
Degron score
Detail
Q4G0A6
Probable ubiquitin carboxyl-terminal hydrolase MINDY-4
DEG_SCF_FBW7_1
169:176
PGETPVLT
FBXW7
0.9822
More...