DegronMD

Uniprot ID: Q4G0A6

Source protein: Probable ubiquitin carboxyl-terminal hydrolase MINDY-4

Source gene: MINDY4

Class: DEG_APCC_DBOX_1

Location: 268:276

E3 ligase: APC,CDC20,FZR1

DEGRON score: 0.9956

ASA_SCORE: 83.1111

COIL: 0.6756

CONS_SCORE: 0.3507

DSS_SCORE: 0.5976

HELIX: 0.3043

FCONS_SCORE: 1.1534

RIG_SCORE: 0.6432

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.L260P	SIDM01126	Small Cell Lung Carcinoma	GDSC	SRTSLGQLS	DEG_APCC_DBOX_1	0.1111
p.L260P	SIDM00746	Non-Small Cell Lung Carcinoma	GDSC	SRTSLGQLS	DEG_APCC_DBOX_1	0.1111
p.L260P	SIDM00210	Ovarian Carcinoma	GDSC	SRTSLGQLS	DEG_APCC_DBOX_1	0.1111
p.L260P	SIDM00114	Non-Small Cell Lung Carcinoma	GDSC	SRTSLGQLS	DEG_APCC_DBOX_1	0.1111
p.L260P	SIDM00539	Esophageal Carcinoma	GDSC	SRTSLGQLS	DEG_APCC_DBOX_1	0.1111
p.L260P	SIDM00068	Colorectal Carcinoma	GDSC	SRTSLGQLS	DEG_APCC_DBOX_1	0.1111
p.L260P	SIDM00720	Mesothelioma	GDSC	SRTSLGQLS	DEG_APCC_DBOX_1	0.1111
p.L260P	SIDM01710	Squamous Cell Lung Carcinoma	GDSC	SRTSLGQLS	DEG_APCC_DBOX_1	0.1111
p.L260P	SIDM01525	Acute Myeloid Leukemia	GDSC	SRTSLGQLS	DEG_APCC_DBOX_1	0.1111

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q4G0A6	Probable ubiquitin carboxyl-terminal hydrolase MINDY-4	DEG_APCC_DBOX_1	268:276	SRTSLGQLS	APC,CDC20,FZR1	0.9956	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons