DegronMD - Q58A45(PAN3)

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Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.R360S	TCGA-5P-A9K0	KIRP	TCGA	PKITPHTS	DEG_SCF_FBW7_1	347:354	Mutation rewiring degron network	0.1667
p.R360S	SIDM00636	Non-Cancerous	GDSC	PKITPHTS	DEG_SCF_FBW7_1	347:354	Mutation rewiring degron network	0.1667
p.R360S	SIDM00145	T-Lymphoblastic Leukemia	GDSC	PKITPHTS	DEG_SCF_FBW7_1	347:354	Mutation rewiring degron network	0.1667
p.R360S	SIDM00153	T-Lymphoblastic Leukemia	GDSC	PKITPHTS	DEG_SCF_FBW7_1	347:354	Mutation rewiring degron network	0.1667
p.R360S	ACH-000964	Leukemia	CCLE	PKITPHTS	DEG_SCF_FBW7_1	347:354	Mutation rewiring degron network	0.1667
p.R360S	ACH-001127	Leukemia	CCLE	PKITPHTS	DEG_SCF_FBW7_1	347:354	Mutation rewiring degron network	0.1667
p.R360S	ACH-002270	Non-Cancerous	CCLE	PKITPHTS	DEG_SCF_FBW7_1	347:354	Mutation rewiring degron network	0.1667
p.R360S	MOLT-4	haematopoietic and lymphoid tissue	COSMIC	PKITPHTS	DEG_SCF_FBW7_1	347:354	Mutation rewiring degron network	0.1667
p.R360S	MC-CAR	haematopoietic and lymphoid tissue	COSMIC	PKITPHTS	DEG_SCF_FBW7_1	347:354	Mutation rewiring degron network	0.1667
p.H352R	TCGA-AB-2806	LAML	TCGA	PKITPHTS	DEG_SCF_FBW7_1	347:354	Mutation altering degron motif	0.7133
p.K348R	TCGA-AG-A02N	READ	TCGA	PKITPHTS	DEG_SCF_FBW7_1	347:354	Mutation altering degron motif	0.6126
p.W275L	TCGA-D3-A2JP	SKCM	TCGA	LQTPNPT	DEG_SCF_FBW7_1	283:289	Mutation rewiring degron network	0.1111
p.W275L	DO47407	SKCM	ICGC	LQTPNPT	DEG_SCF_FBW7_1	283:289	Mutation rewiring degron network	0.1111
p.E292K	TCGA-E6-A1LX	UCEC	TCGA	LQTPNPT	DEG_SCF_FBW7_1	283:289	Mutation rewiring degron network	0.25
p.E292K	SIDM00534	Colorectal Carcinoma	GDSC	LQTPNPT	DEG_SCF_FBW7_1	283:289	Mutation rewiring degron network	0.25
p.E292K	ACH-000986	Colon/Colorectal Cancer	CCLE	LQTPNPT	DEG_SCF_FBW7_1	283:289	Mutation rewiring degron network	0.25
p.E292K	HT-115	large intestine	COSMIC	LQTPNPT	DEG_SCF_FBW7_1	283:289	Mutation rewiring degron network	0.25
p.P364S	TCGA-EE-A2GR	SKCM	TCGA	PKITPHTS	DEG_SCF_FBW7_1	347:354	Mutation rewiring degron network	0.0556
p.P364L	TCGA-EE-A2GR	SKCM	TCGA	PKITPHTS	DEG_SCF_FBW7_1	347:354	Mutation rewiring degron network	0.0556
p.S346F	TCGA-FR-A726	SKCM	TCGA	PKITPHTS	DEG_SCF_FBW7_1	347:354	Mutation blocking phosphorylation signal	0.75
p.P343H	TCGA-GN-A26D	SKCM	TCGA	PKITPHTS	DEG_SCF_FBW7_1	347:354	Mutation rewiring degron network	0.2222
p.T9R	DO222656	BTCA	ICGC	PSSSS	DEG_SPOP_SBC_1	16:20	Mutation rewiring degron network	0.1389
p.S6L	DO10172	COAD	ICGC	PSSSS	DEG_SPOP_SBC_1	16:20	Mutation rewiring degron network	0.0556
p.S6L	DO222762	COCA	ICGC	PSSSS	DEG_SPOP_SBC_1	16:20	Mutation rewiring degron network	0.0556
p.R341K	DO11854	GBM	ICGC	PKITPHTS	DEG_SCF_FBW7_1	347:354	Mutation rewiring degron network	0.1667
p.W13L	DO229015	LICA	ICGC	PSSSS	DEG_SPOP_SBC_1	16:20	Mutation rewiring degron network	0.25
p.D17Y	DO229035	LICA	ICGC	PSSSS	DEG_SPOP_SBC_1	16:20	Mutation altering degron motif	0.7325
p.V273F	DO229035	LICA	ICGC	LQTPNPT	DEG_SCF_FBW7_1	283:289	Mutation rewiring degron network	0.0556
p.V349F	DO229038	LICA	ICGC	PKITPHTS	DEG_SCF_FBW7_1	347:354	Mutation altering degron motif	0.7068
p.W275C	DO229009	LICA	ICGC	LQTPNPT	DEG_SCF_FBW7_1	283:289	Mutation rewiring degron network	0.1111
p.A14S	DO22839	LIHC	ICGC	PSSSS	DEG_SPOP_SBC_1	16:20	Mutation rewiring degron network	0.2778
p.S24L	DO50101	LUSC	ICGC	PSSSS	DEG_SPOP_SBC_1	16:20	Mutation rewiring degron network	0.2222
p.Q344E	DO26469	LUSC	ICGC	PKITPHTS	DEG_SCF_FBW7_1	347:354	Mutation rewiring degron network	0.25
p.G338V	DO46657	PAAD	ICGC	PKITPHTS	DEG_SCF_FBW7_1	347:354	Mutation rewiring degron network	0.0833
p.A12T	DO232224	PBCA	ICGC	PSSSS	DEG_SPOP_SBC_1	16:20	Mutation rewiring degron network	0.2222
p.R352H	DO38707	STAD	ICGC	PKITPHTS	DEG_SCF_FBW7_1	347:354	Mutation altering degron motif	0.8244
p.C346Y	DO47867	STAD	ICGC	PKITPHTS	DEG_SCF_FBW7_1	347:354	Mutation blocking phosphorylation signal	0.75
p.F26S	DO41542	UCEC	ICGC	PSSSS	DEG_SPOP_SBC_1	16:20	Mutation rewiring degron network	0.1667
p.A15V	DO41871	UCEC	ICGC	PSSSS	DEG_SPOP_SBC_1	16:20	Mutation rewiring degron network	0.3056
p.I21N	DO42472	UCEC	ICGC	PSSSS	DEG_SPOP_SBC_1	16:20	Mutation rewiring degron network	0.3056
p.T285I	SIDM00450	Acute Myeloid Leukemia	GDSC	LQTPNPT	DEG_SCF_FBW7_1	283:289	Mutation altering degron motif	0.7078
p.T285I	PL-21	haematopoietic and lymphoid tissue	COSMIC	LQTPNPT	DEG_SCF_FBW7_1	283:289	Mutation altering degron motif	0.7078
p.K348N	SIDM01043	Other Sarcomas	GDSC	PKITPHTS	DEG_SCF_FBW7_1	347:354	Mutation altering degron motif	0.5806
p.K348N	ACH-000913	Endometrial/Uterine Cancer	CCLE	PKITPHTS	DEG_SCF_FBW7_1	347:354	Mutation altering degron motif	0.5806
p.K348N	ESS-1	endometrium	COSMIC	PKITPHTS	DEG_SCF_FBW7_1	347:354	Mutation altering degron motif	0.5806
p.V12G	ACH-000595	Brain Cancer	CCLE	PSSSS	DEG_SPOP_SBC_1	16:20	Mutation rewiring degron network	0.2222
p.P284S	COLO-792	skin	COSMIC	LQTPNPT	DEG_SCF_FBW7_1	283:289	Mutation altering degron motif	0.6752
p.K342E	HuH-7	liver	COSMIC	PKITPHTS	DEG_SCF_FBW7_1	347:354	Mutation rewiring degron network	0.1944

Kaplan plot for PAN3 in

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*NOTE: the Kaplan plots were collected from OncoLnc

DegronMD: protein-targeted degradation, mutation and drug response to degrons

PAN3

UniProt ID: Q58A45

Entrez ID: 255967

Protein name: PAN2-PAN3 deadenylation complex subunit PAN3 (PAB1P-dependent poly(A)-specific ribonuclease) (Poly(A)-nuclease deadenylation complex subunit 3) (PAN deadenylation complex subunit 3)

External links: UniprotKB HGNC RefSeq COSMIC

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Kaplan plot for PAN3 in