DegronMD

Uniprot ID: Q58A45

Source protein: PAN2-PAN3 deadenylation complex subunit PAN3

Source gene: PAN3

Class: DEG_SCF_FBW7_1

Location: 283:289

E3 ligase: FBXW7

DEGRON score: 0.9909

ASA_SCORE: 78.9286

COIL: 0.9191

CONS_SCORE: 0.3442

DSS_SCORE: 0.4801

HELIX: 0.0321

FCONS_SCORE: 0.9765

RIG_SCORE: 0.7163

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.W275L	TCGA-D3-A2JP	SKCM	TCGA	LQTPNPT	DEG_SCF_FBW7_1	0.1111
p.W275L	DO47407	SKCM	ICGC	LQTPNPT	DEG_SCF_FBW7_1	0.1111
p.E292K	TCGA-E6-A1LX	UCEC	TCGA	LQTPNPT	DEG_SCF_FBW7_1	0.25
p.E292K	SIDM00534	Colorectal Carcinoma	GDSC	LQTPNPT	DEG_SCF_FBW7_1	0.25
p.E292K	ACH-000986	Colon/Colorectal Cancer	CCLE	LQTPNPT	DEG_SCF_FBW7_1	0.25
p.E292K	HT-115	large_intestine	COSMIC	LQTPNPT	DEG_SCF_FBW7_1	0.25
p.V273F	DO229035	LICA	ICGC	LQTPNPT	DEG_SCF_FBW7_1	0.0556
p.W275C	DO229009	LICA	ICGC	LQTPNPT	DEG_SCF_FBW7_1	0.1111
p.T285I	SIDM00450	Acute Myeloid Leukemia	GDSC	LQTPNPT	DEG_SCF_FBW7_1	0.7078
p.T285I	PL-21	haematopoietic_and_lymphoid_tissue	COSMIC	LQTPNPT	DEG_SCF_FBW7_1	0.7078
p.P284S	COLO-792	skin	COSMIC	LQTPNPT	DEG_SCF_FBW7_1	0.6752

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q58A45	PAN2-PAN3 deadenylation complex subunit PAN3	DEG_SCF_FBW7_1	283:289	LQTPNPT	FBXW7	0.9909	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons