DegronMD

Uniprot ID: Q58A45

Source protein: PAN2-PAN3 deadenylation complex subunit PAN3

Source gene: PAN3

Class: DEG_SCF_FBW7_1

Location: 347:354

E3 ligase: FBXW7

DEGRON score: 0.9976

ASA_SCORE: 77.7125

COIL: 0.9386

CONS_SCORE: 0.3434

DSS_SCORE: 0.773

HELIX: 0.0235

FCONS_SCORE: 1.012

RIG_SCORE: 0.5651

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.R360S	TCGA-5P-A9K0	KIRP	TCGA	PKITPHTS	DEG_SCF_FBW7_1	0.1667
p.R360S	SIDM00636	Non-Cancerous	GDSC	PKITPHTS	DEG_SCF_FBW7_1	0.1667
p.R360S	SIDM00145	T-Lymphoblastic Leukemia	GDSC	PKITPHTS	DEG_SCF_FBW7_1	0.1667
p.R360S	SIDM00153	T-Lymphoblastic Leukemia	GDSC	PKITPHTS	DEG_SCF_FBW7_1	0.1667
p.R360S	ACH-000964	Leukemia	CCLE	PKITPHTS	DEG_SCF_FBW7_1	0.1667
p.R360S	ACH-001127	Leukemia	CCLE	PKITPHTS	DEG_SCF_FBW7_1	0.1667
p.R360S	ACH-002270	Non-Cancerous	CCLE	PKITPHTS	DEG_SCF_FBW7_1	0.1667
p.R360S	MOLT-4	haematopoietic_and_lymphoid_tissue	COSMIC	PKITPHTS	DEG_SCF_FBW7_1	0.1667
p.R360S	MC-CAR	haematopoietic_and_lymphoid_tissue	COSMIC	PKITPHTS	DEG_SCF_FBW7_1	0.1667
p.H352R	TCGA-AB-2806	LAML	TCGA	PKITPHTS	DEG_SCF_FBW7_1	0.7133
p.K348R	TCGA-AG-A02N	READ	TCGA	PKITPHTS	DEG_SCF_FBW7_1	0.6126
p.P364S	TCGA-EE-A2GR	SKCM	TCGA	PKITPHTS	DEG_SCF_FBW7_1	0.0556
p.P364L	TCGA-EE-A2GR	SKCM	TCGA	PKITPHTS	DEG_SCF_FBW7_1	0.0556
p.S346F	TCGA-FR-A726	SKCM	TCGA	PKITPHTS	DEG_SCF_FBW7_1	0.75
p.P343H	TCGA-GN-A26D	SKCM	TCGA	PKITPHTS	DEG_SCF_FBW7_1	0.2222
p.R341K	DO11854	GBM	ICGC	PKITPHTS	DEG_SCF_FBW7_1	0.1667
p.V349F	DO229038	LICA	ICGC	PKITPHTS	DEG_SCF_FBW7_1	0.7068
p.Q344E	DO26469	LUSC	ICGC	PKITPHTS	DEG_SCF_FBW7_1	0.25
p.G338V	DO46657	PAAD	ICGC	PKITPHTS	DEG_SCF_FBW7_1	0.0833
p.R352H	DO38707	STAD	ICGC	PKITPHTS	DEG_SCF_FBW7_1	0.8244
p.C346Y	DO47867	STAD	ICGC	PKITPHTS	DEG_SCF_FBW7_1	0.75
p.K348N	SIDM01043	Other Sarcomas	GDSC	PKITPHTS	DEG_SCF_FBW7_1	0.5806
p.K348N	ACH-000913	Endometrial/Uterine Cancer	CCLE	PKITPHTS	DEG_SCF_FBW7_1	0.5806
p.K348N	ESS-1	endometrium	COSMIC	PKITPHTS	DEG_SCF_FBW7_1	0.5806
p.K342E	HuH-7	liver	COSMIC	PKITPHTS	DEG_SCF_FBW7_1	0.1944

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q58A45	PAN2-PAN3 deadenylation complex subunit PAN3	DEG_SCF_FBW7_1	347:354	PKITPHTS	FBXW7	0.9976	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons

Degron: PKITPHTS

Degron related mutations and impact score

Drug responses associated with PAN3 mutations

All proteins holding degron of PKITPHTS