DegronMD - Q8N1F7(NUP93)

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Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.V197L	TCGA-55-5899	LUAD	TCGA	IYIYNE	LIG_APCC_ABBA_1	189:194	Mutation rewiring degron network	0.25
p.V197E	TCGA-A5-A0G5	UCEC	TCGA	IYIYNE	LIG_APCC_ABBA_1	189:194	Mutation rewiring degron network	0.25
p.P768L	TCGA-EB-A6R0	SKCM	TCGA	PSSSS	DEG_SPOP_SBC_1	768:772	Mutation altering degron motif	0.7582
p.R781C	TCGA-EY-A215	UCEC	TCGA	PSSSS	DEG_SPOP_SBC_1	768:772	Mutation rewiring degron network	0.0833
p.S770L	TCGA-GF-A3OT	SKCM	TCGA	PSSSS	DEG_SPOP_SBC_1	768:772	Mutation altering degron motif	0.8778
p.Q775H	TCGA-X6-A7WA	SARC	TCGA	PSSSS	DEG_SPOP_SBC_1	768:772	Mutation rewiring degron network	0.25
p.R187W	TCGA-ZF-A9R7	BLCA	TCGA	IYIYNE	LIG_APCC_ABBA_1	189:194	Mutation rewiring degron network	0.2778
p.A197V	DO8842	COAD	ICGC	IYIYNE	LIG_APCC_ABBA_1	189:194	Mutation rewiring degron network	0.25
p.A197V	DO41644	UCEC	ICGC	IYIYNE	LIG_APCC_ABBA_1	189:194	Mutation rewiring degron network	0.25
p.E191K	DO49070	HNSC	ICGC	IYIYNE	LIG_APCC_ABBA_1	189:194	Mutation altering degron motif	0.7022
p.E191K	DO26775	LUSC	ICGC	IYIYNE	LIG_APCC_ABBA_1	189:194	Mutation altering degron motif	0.7022
p.G184V	DO229018	LICA	ICGC	IYIYNE	LIG_APCC_ABBA_1	189:194	Mutation rewiring degron network	0.1944
p.V195L	DO229008	LICA	ICGC	IYIYNE	LIG_APCC_ABBA_1	189:194	Mutation rewiring degron network	0.3056
p.Y201C	DO51778	STAD	ICGC	IYIYNE	LIG_APCC_ABBA_1	189:194	Mutation rewiring degron network	0.1389
p.P183S	DO41999	UCEC	ICGC	IYIYNE	LIG_APCC_ABBA_1	189:194	Mutation rewiring degron network	0.1667
p.R204C	DO43875	UCEC	ICGC	IYIYNE	LIG_APCC_ABBA_1	189:194	Mutation rewiring degron network	0.0556
p.R204C	DO41199	UCEC	ICGC	IYIYNE	LIG_APCC_ABBA_1	189:194	Mutation rewiring degron network	0.0556
p.R204C	LS-411N	large intestine	COSMIC	IYIYNE	LIG_APCC_ABBA_1	189:194	Mutation rewiring degron network	0.0556
p.R781H	SIDM01265	Plasma Cell Myeloma	GDSC	PSSSS	DEG_SPOP_SBC_1	768:772	Mutation rewiring degron network	0.0833
p.E779K	SIDM00879	Breast Carcinoma	GDSC	PSSSS	DEG_SPOP_SBC_1	768:772	Mutation rewiring degron network	0.1389
p.E779K	SIDM01749	Osteosarcoma	GDSC	PSSSS	DEG_SPOP_SBC_1	768:772	Mutation rewiring degron network	0.1389
p.Y192C	SIDM01140	Ovarian Carcinoma	GDSC	IYIYNE	LIG_APCC_ABBA_1	189:194	Mutation altering degron motif	0.7087
p.Y192C	ACH-001374	Ovarian Cancer	CCLE	IYIYNE	LIG_APCC_ABBA_1	189:194	Mutation altering degron motif	0.7087
p.Y192C	PA-1	ovary	COSMIC	IYIYNE	LIG_APCC_ABBA_1	189:194	Mutation altering degron motif	0.7087
p.P179S	LIM1215	large intestine	COSMIC	IYIYNE	LIG_APCC_ABBA_1	189:194	Mutation rewiring degron network	0.0556
p.G192A	SIMA	autonomic ganglia	COSMIC	IYIYNE	LIG_APCC_ABBA_1	189:194	Mutation altering degron motif	0.754

Kaplan plot for NUP93 in

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*NOTE: the Kaplan plots were collected from OncoLnc

DegronMD: protein-targeted degradation, mutation and drug response to degrons

NUP93

UniProt ID: Q8N1F7

Entrez ID: 9688

Protein name: Nuclear pore complex protein Nup93 (93 kDa nucleoporin) (Nucleoporin Nup93)

External links: UniprotKB HGNC RefSeq COSMIC

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Kaplan plot for NUP93 in