DegronMD

Uniprot ID: Q8N1F7

Source protein: Nuclear pore complex protein Nup93

Source gene: NUP93

Class: LIG_APCC_ABBA_1

Location: 189:194

E3 ligase: APC,CDC20,FZR1

DEGRON score: 0.7044

ASA_SCORE: 46.1167

COIL: 0.1363

CONS_SCORE: 0.3915

DSS_SCORE: 0.0825

HELIX: 0.8398

FCONS_SCORE: 1.0744

RIG_SCORE: 0.9246

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.V197L	TCGA-55-5899	LUAD	TCGA	IYIYNE	LIG_APCC_ABBA_1	0.25
p.V197E	TCGA-A5-A0G5	UCEC	TCGA	IYIYNE	LIG_APCC_ABBA_1	0.25
p.R187W	TCGA-ZF-A9R7	BLCA	TCGA	IYIYNE	LIG_APCC_ABBA_1	0.2778
p.A197V	DO8842	COAD	ICGC	IYIYNE	LIG_APCC_ABBA_1	0.25
p.A197V	DO41644	UCEC	ICGC	IYIYNE	LIG_APCC_ABBA_1	0.25
p.E191K	DO49070	HNSC	ICGC	IYIYNE	LIG_APCC_ABBA_1	0.7022
p.E191K	DO26775	LUSC	ICGC	IYIYNE	LIG_APCC_ABBA_1	0.7022
p.G184V	DO229018	LICA	ICGC	IYIYNE	LIG_APCC_ABBA_1	0.1944
p.V195L	DO229008	LICA	ICGC	IYIYNE	LIG_APCC_ABBA_1	0.3056
p.Y201C	DO51778	STAD	ICGC	IYIYNE	LIG_APCC_ABBA_1	0.1389
p.P183S	DO41999	UCEC	ICGC	IYIYNE	LIG_APCC_ABBA_1	0.1667
p.R204C	DO43875	UCEC	ICGC	IYIYNE	LIG_APCC_ABBA_1	0.0556
p.R204C	DO41199	UCEC	ICGC	IYIYNE	LIG_APCC_ABBA_1	0.0556
p.R204C	LS-411N	large_intestine	COSMIC	IYIYNE	LIG_APCC_ABBA_1	0.0556
p.Y192C	SIDM01140	Ovarian Carcinoma	GDSC	IYIYNE	LIG_APCC_ABBA_1	0.7087
p.Y192C	ACH-001374	Ovarian Cancer	CCLE	IYIYNE	LIG_APCC_ABBA_1	0.7087
p.Y192C	PA-1	ovary	COSMIC	IYIYNE	LIG_APCC_ABBA_1	0.7087
p.P179S	LIM1215	large_intestine	COSMIC	IYIYNE	LIG_APCC_ABBA_1	0.0556
p.G192A	SIMA	autonomic_ganglia	COSMIC	IYIYNE	LIG_APCC_ABBA_1	0.754

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q8N1F7	Nuclear pore complex protein Nup93	LIG_APCC_ABBA_1	189:194	IYIYNE	APC,CDC20,FZR1	0.7044	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons