DegronMD - Q7KZ85(SUPT6H)

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Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.K1665R	TCGA-56-7730	LUSC	TCGA	PSSSS	DEG_SPOP_SBC_1	1653:1657	Mutation substituting flanking lysine	0.2222
p.K1665R	DO26617	LUSC	ICGC	PSSSS	DEG_SPOP_SBC_1	1653:1657	Mutation substituting flanking lysine	0.2222
p.P1698H	TCGA-A5-A0G1	UCEC	TCGA	LTPRPS	DEG_SCF_FBW7_1	1696:1701	Mutation altering degron motif	0.7694
p.P1698H	DO42472	UCEC	ICGC	LTPRPS	DEG_SCF_FBW7_1	1696:1701	Mutation altering degron motif	0.7694
p.G1521A	TCGA-A8-A08B	BRCA	TCGA	PGITPSSS	DEG_SCF_FBW7_1	1520:1527	Mutation altering degron motif	0.6429
p.G1521A	DO5012	BRCA	ICGC	PGITPSSS	DEG_SCF_FBW7_1	1520:1527	Mutation altering degron motif	0.6429
p.G307V	TCGA-B5-A5OC	UCEC	TCGA	ERFQLRSIP	DEG_APCC_DBOX_1	296:304	Mutation rewiring degron network	0.25
p.G307V	DO52405	UCEC	ICGC	ERFQLRSIP	DEG_APCC_DBOX_1	296:304	Mutation rewiring degron network	0.25
p.T1624M	TCGA-CG-5723	STAD	TCGA	PVATPLMT	DEG_SCF_FBW7_1	1611:1618	Mutation rewiring degron network	0.1667
p.T1624M	DO38376	STAD	ICGC	PVATPLMT	DEG_SCF_FBW7_1	1611:1618	Mutation rewiring degron network	0.1667
p.R1660W	TCGA-D1-A167	UCEC	TCGA	PSSSS	DEG_SPOP_SBC_1	1653:1657	Mutation rewiring degron network	0.25
p.R1660W	TCGA-FP-A4BE	STAD	TCGA	PSSSS	DEG_SPOP_SBC_1	1653:1657	Mutation rewiring degron network	0.25
p.R1660W	DO48016	STAD	ICGC	PSSSS	DEG_SPOP_SBC_1	1653:1657	Mutation rewiring degron network	0.25
p.R1660W	DO40978	UCEC	ICGC	PSSSS	DEG_SPOP_SBC_1	1653:1657	Mutation rewiring degron network	0.25
p.S1622F	TCGA-D3-A8GN	SKCM	TCGA	PVATPLMT	DEG_SCF_FBW7_1	1611:1618	Mutation rewiring degron network	0.2222
p.S1622F	DO51240	SKCM	ICGC	PVATPLMT	DEG_SCF_FBW7_1	1611:1618	Mutation rewiring degron network	0.2222
p.P1611S	TCGA-DD-AACY	LIHC	TCGA	PVATPLMT	DEG_SCF_FBW7_1	1611:1618	Mutation altering degron motif	0.6752
p.P1611S	DO219567	LIHC	ICGC	PVATPLMT	DEG_SCF_FBW7_1	1611:1618	Mutation altering degron motif	0.6752
p.R1658W	TCGA-DF-A2KU	UCEC	TCGA	PSSSS	DEG_SPOP_SBC_1	1653:1657	Mutation rewiring degron network	0.3056
p.R1658W	TCGA-L5-A8NM	ESCA	TCGA	PSSSS	DEG_SPOP_SBC_1	1653:1657	Mutation rewiring degron network	0.3056
p.R1658W	DO223286	UCEC	ICGC	PSSSS	DEG_SPOP_SBC_1	1653:1657	Mutation rewiring degron network	0.3056
p.A1649V	TCGA-F4-6570	COAD	TCGA	PSSSS	DEG_SPOP_SBC_1	1653:1657	Mutation rewiring degron network	0.2222
p.A1649V	DO10443	COAD	ICGC	PSSSS	DEG_SPOP_SBC_1	1653:1657	Mutation rewiring degron network	0.2222
p.E309K	TCGA-FD-A5BT	BLCA	TCGA	ERFQLRSIP	DEG_APCC_DBOX_1	296:304	Mutation rewiring degron network	0.1944
p.E309K	DO44032	BLCA	ICGC	ERFQLRSIP	DEG_APCC_DBOX_1	296:304	Mutation rewiring degron network	0.1944
p.K306E	TCGA-FI-A2D6	UCEC	TCGA	ERFQLRSIP	DEG_APCC_DBOX_1	296:304	Mutation rewiring degron network	0.2778
p.K306E	DO43867	UCEC	ICGC	ERFQLRSIP	DEG_APCC_DBOX_1	296:304	Mutation rewiring degron network	0.2778
p.P1710S	TCGA-FR-A726	SKCM	TCGA	LTPRPS	DEG_SCF_FBW7_1	1696:1701	Mutation rewiring degron network	0.0833
p.P1710S	DO48665	SKCM	ICGC	LTPRPS	DEG_SCF_FBW7_1	1696:1701	Mutation rewiring degron network	0.0833
p.R1689Q	TCGA-SS-A7HO	COAD	TCGA	LTPRPS	DEG_SCF_FBW7_1	1696:1701	Mutation rewiring degron network	0.1389
p.R1689Q	DO223705	COAD	ICGC	LTPRPS	DEG_SCF_FBW7_1	1696:1701	Mutation rewiring degron network	0.1389
p.E312K	TCGA-VS-A958	CESC	TCGA	ERFQLRSIP	DEG_APCC_DBOX_1	296:304	Mutation rewiring degron network	0.1111
p.E312K	DO51639	CESC	ICGC	ERFQLRSIP	DEG_APCC_DBOX_1	296:304	Mutation rewiring degron network	0.1111
p.A1608S	DO48389	BLCA	ICGC	PVATPLMT	DEG_SCF_FBW7_1	1611:1618	Mutation rewiring degron network	0.25
p.D311N	DO228317	BRCA	ICGC	ERFQLRSIP	DEG_APCC_DBOX_1	296:304	Mutation rewiring degron network	0.1389
p.M1711V	DO233270	GACA	ICGC	LTPRPS	DEG_SCF_FBW7_1	1696:1701	Mutation rewiring degron network	0.0556
p.A308S	DO228948	LICA	ICGC	ERFQLRSIP	DEG_APCC_DBOX_1	296:304	Mutation rewiring degron network	0.2222
p.K1665N	DO228976	LICA	ICGC	PSSSS	DEG_SPOP_SBC_1	1653:1657	Mutation substituting flanking lysine	0.2222
p.K1665N	DO229038	LICA	ICGC	PSSSS	DEG_SPOP_SBC_1	1653:1657	Mutation substituting flanking lysine	0.2222
p.R1529S	DO229028	LICA	ICGC	PGITPSSS	DEG_SCF_FBW7_1	1520:1527	Mutation rewiring degron network	0.2778
p.R1529S	DO229028	LICA	ICGC	PSSSS	DEG_SPOP_SBC_1	1524:1528	Mutation rewiring degron network	0.3056
p.A1534S	DO229041	LICA	ICGC	PGITPSSS	DEG_SCF_FBW7_1	1520:1527	Mutation rewiring degron network	0.1389
p.A1534S	DO229041	LICA	ICGC	PSSSS	DEG_SPOP_SBC_1	1524:1528	Mutation rewiring degron network	0.1667
p.P1524L	DO44660	LICA	ICGC	PGITPSSS	DEG_SCF_FBW7_1	1520:1527	Mutation altering degron motif	0.7582
p.P1524L	DO44660	LICA	ICGC	PSSSS	DEG_SPOP_SBC_1	1524:1528	Mutation altering degron motif	0.7582
p.I1536V	DO45097	LIRI	ICGC	PGITPSSS	DEG_SCF_FBW7_1	1520:1527	Mutation rewiring degron network	0.0833
p.I1536V	DO45097	LIRI	ICGC	PSSSS	DEG_SPOP_SBC_1	1524:1528	Mutation rewiring degron network	0.1111
p.R301H	DO46836	RECA	ICGC	ERFQLRSIP	DEG_APCC_DBOX_1	296:304	Mutation altering degron motif	0.7133
p.T1523P	DO229453	SKCA	ICGC	PGITPSSS	DEG_SCF_FBW7_1	1520:1527	Mutation altering degron motif	0.8142
p.S1528R	SIDM01016	T-Lymphoblastic Leukemia	GDSC	PSSSS	DEG_SPOP_SBC_1	1524:1528	Mutation altering degron motif	0.8538
p.S1528R	SIDM01263	T-Lymphoblastic Leukemia	GDSC	PSSSS	DEG_SPOP_SBC_1	1524:1528	Mutation altering degron motif	0.8538
p.S1528R	ACH-000995	Leukemia	CCLE	PSSSS	DEG_SPOP_SBC_1	1524:1528	Mutation altering degron motif	0.8538
p.S1528R	Jurkat	haematopoietic and lymphoid tissue	COSMIC	PSSSS	DEG_SPOP_SBC_1	1524:1528	Mutation altering degron motif	0.8538
p.R290Q	SIDM00262	Ewing's Sarcoma	GDSC	ERFQLRSIP	DEG_APCC_DBOX_1	296:304	Mutation rewiring degron network	0.1667
p.R290Q	ACH-002107	Bone Cancer	CCLE	ERFQLRSIP	DEG_APCC_DBOX_1	296:304	Mutation rewiring degron network	0.1667
p.R290Q	ES6	bone	COSMIC	ERFQLRSIP	DEG_APCC_DBOX_1	296:304	Mutation rewiring degron network	0.1667
p.E296Q	SIDM00350	Head and Neck Carcinoma	GDSC	ERFQLRSIP	DEG_APCC_DBOX_1	296:304	Mutation altering degron motif	0.5633
p.E296Q	ACH-001641	Head and Neck Cancer	CCLE	ERFQLRSIP	DEG_APCC_DBOX_1	296:304	Mutation altering degron motif	0.5633
p.E296Q	SAT	upper aerodigestive tract	COSMIC	ERFQLRSIP	DEG_APCC_DBOX_1	296:304	Mutation altering degron motif	0.5633
p.P1700S	SIDM00516	Melanoma	GDSC	LTPRPS	DEG_SCF_FBW7_1	1696:1701	Mutation altering degron motif	0.5641
p.P1700S	ACH-002166	Skin Cancer	CCLE	LTPRPS	DEG_SCF_FBW7_1	1696:1701	Mutation altering degron motif	0.5641
p.P1700S	MZ7-mel	skin	COSMIC	LTPRPS	DEG_SCF_FBW7_1	1696:1701	Mutation altering degron motif	0.5641
p.T292A	SIDM00793	Burkitt's Lymphoma	GDSC	ERFQLRSIP	DEG_APCC_DBOX_1	296:304	Mutation blocking phosphorylation signal	0.6667
p.T292A	ACH-002236	Lymphoma	CCLE	ERFQLRSIP	DEG_APCC_DBOX_1	296:304	Mutation blocking phosphorylation signal	0.6667
p.T292A	EB-3	haematopoietic and lymphoid tissue	COSMIC	ERFQLRSIP	DEG_APCC_DBOX_1	296:304	Mutation blocking phosphorylation signal	0.6667
p.R1658Q	SIDM00217	Colorectal Carcinoma	GDSC	PSSSS	DEG_SPOP_SBC_1	1653:1657	Mutation rewiring degron network	0.3056
p.R1658Q	ACH-000999	Colon/Colorectal Cancer	CCLE	PSSSS	DEG_SPOP_SBC_1	1653:1657	Mutation rewiring degron network	0.3056
p.R1658Q	SNU-1040	large intestine	COSMIC	PSSSS	DEG_SPOP_SBC_1	1653:1657	Mutation rewiring degron network	0.3056
p.T1624A	ACH-001698	Head and Neck Cancer	CCLE	PVATPLMT	DEG_SCF_FBW7_1	1611:1618	Mutation rewiring degron network	0.1667

Kaplan plot for SUPT6H in

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*NOTE: the Kaplan plots were collected from OncoLnc

DegronMD: protein-targeted degradation, mutation and drug response to degrons

SUPT6H

UniProt ID: Q7KZ85

Entrez ID: 6830

Protein name: Transcription elongation factor SPT6 (hSPT6) (Histone chaperone suppressor of Ty6) (Tat-cotransactivator 2 protein) (Tat-CT2 protein)

External links: UniprotKB HGNC RefSeq COSMIC

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Kaplan plot for SUPT6H in