DegronMD

Uniprot ID: Q7KZ85

Source protein: Transcription elongation factor SPT6

Source gene: SUPT6H

Class: DEG_SCF_FBW7_1

Location: 1520:1527

E3 ligase: FBXW7

DEGRON score: 0.9296

ASA_SCORE: 86.4

COIL: 0.9503

CONS_SCORE: 0.2254

DSS_SCORE: 0.5947

HELIX: 0.023

FCONS_SCORE: 0.7348

RIG_SCORE: 0.6422

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.G1521A	TCGA-A8-A08B	BRCA	TCGA	PGITPSSS	DEG_SCF_FBW7_1	0.6429
p.G1521A	DO5012	BRCA	ICGC	PGITPSSS	DEG_SCF_FBW7_1	0.6429
p.R1529S	DO229028	LICA	ICGC	PGITPSSS	DEG_SCF_FBW7_1	0.2778
p.A1534S	DO229041	LICA	ICGC	PGITPSSS	DEG_SCF_FBW7_1	0.1389
p.P1524L	DO44660	LICA	ICGC	PGITPSSS	DEG_SCF_FBW7_1	0.7582
p.I1536V	DO45097	LIRI	ICGC	PGITPSSS	DEG_SCF_FBW7_1	0.0833
p.T1523P	DO229453	SKCA	ICGC	PGITPSSS	DEG_SCF_FBW7_1	0.8142

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q7KZ85	Transcription elongation factor SPT6	DEG_SCF_FBW7_1	1520:1527	PGITPSSS	FBXW7	0.9296	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons