DegronMD

Uniprot ID: Q7KZ85

Source protein: Transcription elongation factor SPT6

Source gene: SUPT6H

Class: DEG_SCF_FBW7_1

Location: 1611:1618

E3 ligase: FBXW7

DEGRON score: 0.9805

ASA_SCORE: 66.8125

COIL: 0.9156

CONS_SCORE: 0.2358

DSS_SCORE: 0.4905

HELIX: 0.0249

FCONS_SCORE: 1.0245

RIG_SCORE: 0.7248

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.T1624M	TCGA-CG-5723	STAD	TCGA	PVATPLMT	DEG_SCF_FBW7_1	0.1667
p.T1624M	DO38376	STAD	ICGC	PVATPLMT	DEG_SCF_FBW7_1	0.1667
p.S1622F	TCGA-D3-A8GN	SKCM	TCGA	PVATPLMT	DEG_SCF_FBW7_1	0.2222
p.S1622F	DO51240	SKCM	ICGC	PVATPLMT	DEG_SCF_FBW7_1	0.2222
p.P1611S	TCGA-DD-AACY	LIHC	TCGA	PVATPLMT	DEG_SCF_FBW7_1	0.6752
p.P1611S	DO219567	LIHC	ICGC	PVATPLMT	DEG_SCF_FBW7_1	0.6752
p.A1608S	DO48389	BLCA	ICGC	PVATPLMT	DEG_SCF_FBW7_1	0.25
p.T1624A	ACH-001698	Head and Neck Cancer	CCLE	PVATPLMT	DEG_SCF_FBW7_1	0.1667

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q7KZ85	Transcription elongation factor SPT6	DEG_SCF_FBW7_1	1611:1618	PVATPLMT	FBXW7	0.9805	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons