DegronMD

Uniprot ID: Q7KZ85

Source protein: Transcription elongation factor SPT6

Source gene: SUPT6H

Class: DEG_APCC_DBOX_1

Location: 296:304

E3 ligase: APC,CDC20,FZR1

DEGRON score: 0.9791

ASA_SCORE: 76.8222

COIL: 0.5206

CONS_SCORE: 0.53

DSS_SCORE: 0.4533

HELIX: 0.4516

FCONS_SCORE: 1.1828

RIG_SCORE: 0.7814

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.G307V	TCGA-B5-A5OC	UCEC	TCGA	ERFQLRSIP	DEG_APCC_DBOX_1	0.25
p.G307V	DO52405	UCEC	ICGC	ERFQLRSIP	DEG_APCC_DBOX_1	0.25
p.E309K	TCGA-FD-A5BT	BLCA	TCGA	ERFQLRSIP	DEG_APCC_DBOX_1	0.1944
p.E309K	DO44032	BLCA	ICGC	ERFQLRSIP	DEG_APCC_DBOX_1	0.1944
p.K306E	TCGA-FI-A2D6	UCEC	TCGA	ERFQLRSIP	DEG_APCC_DBOX_1	0.2778
p.K306E	DO43867	UCEC	ICGC	ERFQLRSIP	DEG_APCC_DBOX_1	0.2778
p.E312K	TCGA-VS-A958	CESC	TCGA	ERFQLRSIP	DEG_APCC_DBOX_1	0.1111
p.E312K	DO51639	CESC	ICGC	ERFQLRSIP	DEG_APCC_DBOX_1	0.1111
p.D311N	DO228317	BRCA	ICGC	ERFQLRSIP	DEG_APCC_DBOX_1	0.1389
p.A308S	DO228948	LICA	ICGC	ERFQLRSIP	DEG_APCC_DBOX_1	0.2222
p.R301H	DO46836	RECA	ICGC	ERFQLRSIP	DEG_APCC_DBOX_1	0.7133
p.R290Q	SIDM00262	Ewing's Sarcoma	GDSC	ERFQLRSIP	DEG_APCC_DBOX_1	0.1667
p.R290Q	ACH-002107	Bone Cancer	CCLE	ERFQLRSIP	DEG_APCC_DBOX_1	0.1667
p.R290Q	ES6	bone	COSMIC	ERFQLRSIP	DEG_APCC_DBOX_1	0.1667
p.E296Q	SIDM00350	Head and Neck Carcinoma	GDSC	ERFQLRSIP	DEG_APCC_DBOX_1	0.5633
p.E296Q	ACH-001641	Head and Neck Cancer	CCLE	ERFQLRSIP	DEG_APCC_DBOX_1	0.5633
p.E296Q	SAT	upper_aerodigestive_tract	COSMIC	ERFQLRSIP	DEG_APCC_DBOX_1	0.5633
p.T292A	SIDM00793	Burkitt's Lymphoma	GDSC	ERFQLRSIP	DEG_APCC_DBOX_1	0.6667
p.T292A	ACH-002236	Lymphoma	CCLE	ERFQLRSIP	DEG_APCC_DBOX_1	0.6667
p.T292A	EB-3	haematopoietic_and_lymphoid_tissue	COSMIC	ERFQLRSIP	DEG_APCC_DBOX_1	0.6667

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q7KZ85	Transcription elongation factor SPT6	DEG_APCC_DBOX_1	296:304	ERFQLRSIP	APC,CDC20,FZR1	0.9791	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons