DegronMD

Uniprot ID: Q7KZ85

Source protein: Transcription elongation factor SPT6

Source gene: SUPT6H

Class: DEG_SCF_FBW7_1

Location: 1696:1701

E3 ligase: FBXW7

DEGRON score: 0.9302

ASA_SCORE: 98.6667

COIL: 0.9578

CONS_SCORE: 0.2211

DSS_SCORE: 0.783

HELIX: 0.0162

FCONS_SCORE: 0.9357

RIG_SCORE: 0.5821

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.P1698H	TCGA-A5-A0G1	UCEC	TCGA	LTPRPS	DEG_SCF_FBW7_1	0.7694
p.P1698H	DO42472	UCEC	ICGC	LTPRPS	DEG_SCF_FBW7_1	0.7694
p.P1710S	TCGA-FR-A726	SKCM	TCGA	LTPRPS	DEG_SCF_FBW7_1	0.0833
p.P1710S	DO48665	SKCM	ICGC	LTPRPS	DEG_SCF_FBW7_1	0.0833
p.R1689Q	TCGA-SS-A7HO	COAD	TCGA	LTPRPS	DEG_SCF_FBW7_1	0.1389
p.R1689Q	DO223705	COAD	ICGC	LTPRPS	DEG_SCF_FBW7_1	0.1389
p.M1711V	DO233270	GACA	ICGC	LTPRPS	DEG_SCF_FBW7_1	0.0556
p.P1700S	SIDM00516	Melanoma	GDSC	LTPRPS	DEG_SCF_FBW7_1	0.5641
p.P1700S	ACH-002166	Skin Cancer	CCLE	LTPRPS	DEG_SCF_FBW7_1	0.5641
p.P1700S	MZ7-mel	skin	COSMIC	LTPRPS	DEG_SCF_FBW7_1	0.5641

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q7KZ85	Transcription elongation factor SPT6	DEG_SCF_FBW7_1	1696:1701	LTPRPS	FBXW7	0.9302	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons