DegronMD - Q9P0U3(SENP1)

GO - Biological processes (BP): View more >>

GO - Molecular function (MF): View more >>

GO - Cellular component (CC): View more >>

Choose a PDB ID:
Open in full screen with detailed sequence annotations

Data table is loading....

Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.R113T	TCGA-52-7810	LUSC	TCGA	PSSSS	DEG_SPOP_SBC_1	103:107	Mutation rewiring degron network	0.1667
p.R113T	DO27381	LUSC	ICGC	PSSSS	DEG_SPOP_SBC_1	103:107	Mutation rewiring degron network	0.1667
p.A94T	TCGA-AR-A24O	BRCA	TCGA	PSSSS	DEG_SPOP_SBC_1	103:107	Mutation rewiring degron network	0.0833
p.A94T	DO5759	BRCA	ICGC	PSSSS	DEG_SPOP_SBC_1	103:107	Mutation rewiring degron network	0.0833
p.T59A	TCGA-BS-A0UJ	UCEC	TCGA	NPSYYSDNP	CBL_PTK	68:76	Mutation blocking phosphorylation signal	0.5278
p.T59A	DO42745	UCEC	ICGC	NPSYYSDNP	CBL_PTK	68:76	Mutation blocking phosphorylation signal	0.5278
p.Q327K	TCGA-D3-A2JD	SKCM	TCGA	PTPSST	DEG_SCF_FBW7_1	329:334	Mutation rewiring degron network	0.2778
p.Q327K	DO37543	SKCM	ICGC	PTPSST	DEG_SCF_FBW7_1	329:334	Mutation rewiring degron network	0.2778
p.S78L	TCGA-E6-A1LZ	UCEC	TCGA	NPSYYSDNP	CBL_PTK	68:76	Mutation blocking phosphorylation signal	0.7222
p.G85D	TCGA-E6-A2P9	UCEC	TCGA	NPSYYSDNP	CBL_PTK	68:76	Mutation rewiring degron network	0.0833
p.G85D	DO43714	UCEC	ICGC	NPSYYSDNP	CBL_PTK	68:76	Mutation rewiring degron network	0.0833
p.P76S	TCGA-EB-A3XB	SKCM	TCGA	NPSYYSDNP	CBL_PTK	68:76	Mutation altering degron motif	0.6752
p.P76S	DO37856	SKCM	ICGC	NPSYYSDNP	CBL_PTK	68:76	Mutation altering degron motif	0.6752
p.P103S	TCGA-RP-A694	SKCM	TCGA	PSSSS	DEG_SPOP_SBC_1	103:107	Mutation altering degron motif	0.6752
p.P103S	DO51269	SKCM	ICGC	PSSSS	DEG_SPOP_SBC_1	103:107	Mutation altering degron motif	0.6752
p.F336L	DO234333	ESAD	ICGC	PTPSST	DEG_SCF_FBW7_1	329:334	Mutation rewiring degron network	0.2778
p.R114K	DO11657	GBM	ICGC	PSSSS	DEG_SPOP_SBC_1	103:107	Mutation rewiring degron network	0.1389
p.P107T	DO229045	LICA	ICGC	PSSSS	DEG_SPOP_SBC_1	103:107	Mutation altering degron motif	0.7031
p.S84P	DO48518	LIHC	ICGC	NPSYYSDNP	CBL_PTK	68:76	Mutation rewiring degron network	0.1111
p.A113P	DO45328	LUAD	ICGC	PSSSS	DEG_SPOP_SBC_1	103:107	Mutation rewiring degron network	0.1667
p.S326Y	DO224541	LUSC	ICGC	PTPSST	DEG_SCF_FBW7_1	329:334	Mutation rewiring degron network	0.25
p.S326Y	DO231003	LUSC	ICGC	PTPSST	DEG_SCF_FBW7_1	329:334	Mutation rewiring degron network	0.25
p.P76T	DO27893	ORCA	ICGC	NPSYYSDNP	CBL_PTK	68:76	Mutation altering degron motif	0.7031
p.P107L	DO38006	SKCM	ICGC	PSSSS	DEG_SPOP_SBC_1	103:107	Mutation altering degron motif	0.7582
p.S80R	DO38404	STAD	ICGC	NPSYYSDNP	CBL_PTK	68:76	Mutation blocking phosphorylation signal	0.6667
p.P103L	SIDM00545	Melanoma	GDSC	PSSSS	DEG_SPOP_SBC_1	103:107	Mutation altering degron motif	0.7582
p.P103L	ACH-000987	Skin Cancer	CCLE	PSSSS	DEG_SPOP_SBC_1	103:107	Mutation altering degron motif	0.7582
p.P103L	Mewo	skin	COSMIC	PSSSS	DEG_SPOP_SBC_1	103:107	Mutation altering degron motif	0.7582
p.S101F	SIDM00545	Melanoma	GDSC	PSSSS	DEG_SPOP_SBC_1	103:107	Mutation rewiring degron network	0.2778
p.S101F	ACH-000987	Skin Cancer	CCLE	PSSSS	DEG_SPOP_SBC_1	103:107	Mutation rewiring degron network	0.2778
p.S101F	Mewo	skin	COSMIC	PSSSS	DEG_SPOP_SBC_1	103:107	Mutation rewiring degron network	0.2778
p.S117C	SIDM01197	Colorectal Carcinoma	GDSC	PSSSS	DEG_SPOP_SBC_1	103:107	Mutation blocking phosphorylation signal	0.5
p.S117C	ACH-000722	Colon/Colorectal Cancer	CCLE	PSSSS	DEG_SPOP_SBC_1	103:107	Mutation blocking phosphorylation signal	0.5
p.S117C	SNU-C1	large intestine	COSMIC	PSSSS	DEG_SPOP_SBC_1	103:107	Mutation blocking phosphorylation signal	0.5
p.D325H	SIDM01186	Breast Carcinoma	GDSC	PTPSST	DEG_SCF_FBW7_1	329:334	Mutation rewiring degron network	0.2222
p.D325H	ACH-000554	Breast Cancer	CCLE	PTPSST	DEG_SCF_FBW7_1	329:334	Mutation rewiring degron network	0.2222
p.D325H	UACC-893	breast	COSMIC	PTPSST	DEG_SCF_FBW7_1	329:334	Mutation rewiring degron network	0.2222
p.R116Q	SIDM00151	Ovarian Carcinoma	GDSC	PSSSS	DEG_SPOP_SBC_1	103:107	Mutation rewiring degron network	0.0833
p.R116Q	ACH-000966	Ovarian Cancer	CCLE	PSSSS	DEG_SPOP_SBC_1	103:107	Mutation rewiring degron network	0.0833
p.R116Q	IGROV-1	ovary	COSMIC	PSSSS	DEG_SPOP_SBC_1	103:107	Mutation rewiring degron network	0.0833
p.L109F	SIDM00927	Small Cell Lung Carcinoma	GDSC	PSSSS	DEG_SPOP_SBC_1	103:107	Mutation rewiring degron network	0.2778
p.L109F	ACH-000871	Lung Cancer	CCLE	PSSSS	DEG_SPOP_SBC_1	103:107	Mutation rewiring degron network	0.2778
p.L109F	NCI-H510A	lung	COSMIC	PSSSS	DEG_SPOP_SBC_1	103:107	Mutation rewiring degron network	0.2778
p.F335L	SIDM00097	Breast Carcinoma	GDSC	PTPSST	DEG_SCF_FBW7_1	329:334	Mutation rewiring degron network	0.3056
p.F335L	ACH-000147	Breast Cancer	CCLE	PTPSST	DEG_SCF_FBW7_1	329:334	Mutation rewiring degron network	0.3056
p.F335L	T47D	breast	COSMIC	PTPSST	DEG_SCF_FBW7_1	329:334	Mutation rewiring degron network	0.3056

Kaplan plot for SENP1 in

Select cancer type:
Download patient class data (Lower:Upper = 50%:50%)

*NOTE: the Kaplan plots were collected from OncoLnc

DegronMD: protein-targeted degradation, mutation and drug response to degrons

SENP1

UniProt ID: Q9P0U3

Entrez ID: 29843

Protein name: Sentrin-specific protease 1 (EC 3.4.22.-) (Sentrin/SUMO-specific protease SENP1)

External links: UniprotKB HGNC RefSeq COSMIC

Data table is loading....

Kaplan plot for SENP1 in