DegronMD

Uniprot ID: Q9P0U3

Source protein: Sentrin-specific protease 1

Source gene: SENP1

Class: DEG_SCF_FBW7_1

Location: 329:334

E3 ligase: FBXW7

DEGRON score: 0.9995

ASA_SCORE: 73.2167

COIL: 0.8525

CONS_SCORE: 0.351

DSS_SCORE: 0.3465

HELIX: 0.1168

FCONS_SCORE: 1.0958

RIG_SCORE: 0.7096

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.Q327K	TCGA-D3-A2JD	SKCM	TCGA	PTPSST	DEG_SCF_FBW7_1	0.2778
p.Q327K	DO37543	SKCM	ICGC	PTPSST	DEG_SCF_FBW7_1	0.2778
p.F336L	DO234333	ESAD	ICGC	PTPSST	DEG_SCF_FBW7_1	0.2778
p.S326Y	DO224541	LUSC	ICGC	PTPSST	DEG_SCF_FBW7_1	0.25
p.S326Y	DO231003	LUSC	ICGC	PTPSST	DEG_SCF_FBW7_1	0.25
p.D325H	SIDM01186	Breast Carcinoma	GDSC	PTPSST	DEG_SCF_FBW7_1	0.2222
p.D325H	ACH-000554	Breast Cancer	CCLE	PTPSST	DEG_SCF_FBW7_1	0.2222
p.D325H	UACC-893	breast	COSMIC	PTPSST	DEG_SCF_FBW7_1	0.2222
p.F335L	SIDM00097	Breast Carcinoma	GDSC	PTPSST	DEG_SCF_FBW7_1	0.3056
p.F335L	ACH-000147	Breast Cancer	CCLE	PTPSST	DEG_SCF_FBW7_1	0.3056
p.F335L	T47D	breast	COSMIC	PTPSST	DEG_SCF_FBW7_1	0.3056

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q9P0U3	Sentrin-specific protease 1	DEG_SCF_FBW7_1	329:334	PTPSST	FBXW7	0.9995	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons