DegronMD - Q8NE35(CPEB3)

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Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.L331V	TCGA-39-5035	LUSC	TCGA	LLPFQD	LIG_APCC_ABBA_1	331:336	Mutation altering degron motif	0.5654
p.L331V	DO27310	LUSC	ICGC	LLPFQD	LIG_APCC_ABBA_1	331:336	Mutation altering degron motif	0.5654
p.S37P	TCGA-CA-6717	COAD	TCGA	PSTPLSS	DEG_SCF_FBW7_1	36:42	Mutation altering degron motif	0.5641
p.S37P	DO8264	COAD	ICGC	PSTPLSS	DEG_SCF_FBW7_1	36:42	Mutation altering degron motif	0.5641
p.R337L	TCGA-D3-A2JO	SKCM	TCGA	LLPFQD	LIG_APCC_ABBA_1	331:336	Mutation rewiring degron network	0.3056
p.R337L	DO47619	SKCM	ICGC	LLPFQD	LIG_APCC_ABBA_1	331:336	Mutation rewiring degron network	0.3056
p.R337W	TCGA-T3-A92M	HNSC	TCGA	LLPFQD	LIG_APCC_ABBA_1	331:336	Mutation rewiring degron network	0.3056
p.R337W	DO223269	HNSC	ICGC	LLPFQD	LIG_APCC_ABBA_1	331:336	Mutation rewiring degron network	0.3056
p.N321T	DO8264	COAD	ICGC	LLPFQD	LIG_APCC_ABBA_1	331:336	Mutation rewiring degron network	0.0556
p.P340S	DO227979	COCA	ICGC	LLPFQD	LIG_APCC_ABBA_1	331:336	Mutation rewiring degron network	0.2222
p.K219E	DO233898	GACA	ICGC	PSSSS	DEG_SPOP_SBC_1	220:224	Mutation rewiring degron network	0.3056
p.T44N	DO229037	LICA	ICGC	PSTPLSS	DEG_SCF_FBW7_1	36:42	Mutation rewiring degron network	0.2778
p.A322D	DO229045	LICA	ICGC	LLPFQD	LIG_APCC_ABBA_1	331:336	Mutation rewiring degron network	0.0833
p.A322T	DO229126	NKTL	ICGC	LLPFQD	LIG_APCC_ABBA_1	331:336	Mutation rewiring degron network	0.0833
p.A231D	DO50721	ORCA	ICGC	PSSSS	DEG_SPOP_SBC_1	220:224	Mutation rewiring degron network	0.1389
p.A52E	DO50713	ORCA	ICGC	PSTPLSS	DEG_SCF_FBW7_1	36:42	Mutation rewiring degron network	0.0556
p.G328S	DO229502	SKCA	ICGC	LLPFQD	LIG_APCC_ABBA_1	331:336	Mutation rewiring degron network	0.25
p.A227T	DO229213	THCA	ICGC	PSSSS	DEG_SPOP_SBC_1	220:224	Mutation rewiring degron network	0.25
p.N330T	SIDM01141	Ovarian Carcinoma	GDSC	LLPFQD	LIG_APCC_ABBA_1	331:336	Mutation rewiring degron network	0.3056
p.N330T	ACH-000291	Ovarian Cancer	CCLE	LLPFQD	LIG_APCC_ABBA_1	331:336	Mutation rewiring degron network	0.3056
p.S51N	SIDM00311	Mesothelioma	GDSC	PSTPLSS	DEG_SCF_FBW7_1	36:42	Mutation rewiring degron network	0.0833
p.T343A	SIDM00217	Colorectal Carcinoma	GDSC	LLPFQD	LIG_APCC_ABBA_1	331:336	Mutation rewiring degron network	0.1389
p.T343A	ACH-000999	Colon/Colorectal Cancer	CCLE	LLPFQD	LIG_APCC_ABBA_1	331:336	Mutation rewiring degron network	0.1389
p.T343A	SNU-1040	large intestine	COSMIC	LLPFQD	LIG_APCC_ABBA_1	331:336	Mutation rewiring degron network	0.1389
p.A35S	ACH-000888	Lung Cancer	CCLE	PSTPLSS	DEG_SCF_FBW7_1	36:42	Mutation rewiring degron network	0.3056
p.S42L	ACH-001412	Bladder Cancer	CCLE	PSTPLSS	DEG_SCF_FBW7_1	36:42	Mutation altering degron motif	0.7667

Kaplan plot for CPEB3 in

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*NOTE: the Kaplan plots were collected from OncoLnc

DegronMD: protein-targeted degradation, mutation and drug response to degrons

CPEB3

UniProt ID: Q8NE35

Entrez ID: 22849

Protein name: Cytoplasmic polyadenylation element-binding protein 3 (CPE-BP3) (CPE-binding protein 3) (hCPEB-3)

External links: UniprotKB HGNC RefSeq COSMIC

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Kaplan plot for CPEB3 in