DegronMD

Uniprot ID: Q8NE35

Source protein: Cytoplasmic polyadenylation element-binding protein 3

Source gene: CPEB3

Class: LIG_APCC_ABBA_1

Location: 331:336

E3 ligase: APC,CDC20,FZR1

DEGRON score: 0.971

ASA_SCORE: 67.75

COIL: 0.719

CONS_SCORE: 0.387

DSS_SCORE: 0.4564

HELIX: 0.2118

FCONS_SCORE: 1.0497

RIG_SCORE: 0.7613

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.L331V	TCGA-39-5035	LUSC	TCGA	LLPFQD	LIG_APCC_ABBA_1	0.5654
p.L331V	DO27310	LUSC	ICGC	LLPFQD	LIG_APCC_ABBA_1	0.5654
p.R337L	TCGA-D3-A2JO	SKCM	TCGA	LLPFQD	LIG_APCC_ABBA_1	0.3056
p.R337L	DO47619	SKCM	ICGC	LLPFQD	LIG_APCC_ABBA_1	0.3056
p.R337W	TCGA-T3-A92M	HNSC	TCGA	LLPFQD	LIG_APCC_ABBA_1	0.3056
p.R337W	DO223269	HNSC	ICGC	LLPFQD	LIG_APCC_ABBA_1	0.3056
p.N321T	DO8264	COAD	ICGC	LLPFQD	LIG_APCC_ABBA_1	0.0556
p.P340S	DO227979	COCA	ICGC	LLPFQD	LIG_APCC_ABBA_1	0.2222
p.A322D	DO229045	LICA	ICGC	LLPFQD	LIG_APCC_ABBA_1	0.0833
p.A322T	DO229126	NKTL	ICGC	LLPFQD	LIG_APCC_ABBA_1	0.0833
p.G328S	DO229502	SKCA	ICGC	LLPFQD	LIG_APCC_ABBA_1	0.25
p.N330T	SIDM01141	Ovarian Carcinoma	GDSC	LLPFQD	LIG_APCC_ABBA_1	0.3056
p.N330T	ACH-000291	Ovarian Cancer	CCLE	LLPFQD	LIG_APCC_ABBA_1	0.3056
p.T343A	SIDM00217	Colorectal Carcinoma	GDSC	LLPFQD	LIG_APCC_ABBA_1	0.1389
p.T343A	ACH-000999	Colon/Colorectal Cancer	CCLE	LLPFQD	LIG_APCC_ABBA_1	0.1389
p.T343A	SNU-1040	large_intestine	COSMIC	LLPFQD	LIG_APCC_ABBA_1	0.1389

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q8NE35	Cytoplasmic polyadenylation element-binding protein 3	LIG_APCC_ABBA_1	331:336	LLPFQD	APC,CDC20,FZR1	0.971	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons