DegronMD

Uniprot ID: Q8NE35

Source protein: Cytoplasmic polyadenylation element-binding protein 3

Source gene: CPEB3

Class: DEG_SCF_FBW7_1

Location: 36:42

E3 ligase: FBXW7

DEGRON score: 0.9822

ASA_SCORE: 88.9429

COIL: 0.9613

CONS_SCORE: 0.411

DSS_SCORE: 0.8567

HELIX: 0.0211

FCONS_SCORE: 1.184

RIG_SCORE: 0.4943

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.S37P	TCGA-CA-6717	COAD	TCGA	PSTPLSS	DEG_SCF_FBW7_1	0.5641
p.S37P	DO8264	COAD	ICGC	PSTPLSS	DEG_SCF_FBW7_1	0.5641
p.T44N	DO229037	LICA	ICGC	PSTPLSS	DEG_SCF_FBW7_1	0.2778
p.A52E	DO50713	ORCA	ICGC	PSTPLSS	DEG_SCF_FBW7_1	0.0556
p.S51N	SIDM00311	Mesothelioma	GDSC	PSTPLSS	DEG_SCF_FBW7_1	0.0833
p.A35S	ACH-000888	Lung Cancer	CCLE	PSTPLSS	DEG_SCF_FBW7_1	0.3056
p.S42L	ACH-001412	Bladder Cancer	CCLE	PSTPLSS	DEG_SCF_FBW7_1	0.7667

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q8NE35	Cytoplasmic polyadenylation element-binding protein 3	DEG_SCF_FBW7_1	36:42	PSTPLSS	FBXW7	0.9822	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons