DegronMD - Q9NVW2(RLIM)

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Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.Q69R	TCGA-19-1788	GBM	TCGA	LLGTPGES	DEG_SCF_FBW7_1	52:59	Mutation rewiring degron network	0.0556
p.Q69R	DO12712	GBM	ICGC	LLGTPGES	DEG_SCF_FBW7_1	52:59	Mutation rewiring degron network	0.0556
p.G483D	TCGA-24-2019	OV	TCGA	PSSSS	DEG_SPOP_SBC_1	477:481	Mutation rewiring degron network	0.2778
p.G483D	DO31520	OV	ICGC	PSSSS	DEG_SPOP_SBC_1	477:481	Mutation rewiring degron network	0.2778
p.S467Y	TCGA-33-AAS8	LUSC	TCGA	PSSSS	DEG_SPOP_SBC_1	477:481	Mutation rewiring degron network	0.0556
p.S467Y	DO219123	LUSC	ICGC	PSSSS	DEG_SPOP_SBC_1	477:481	Mutation rewiring degron network	0.0556
p.M235V	TCGA-44-7659	LUAD	TCGA	SRSPLHPMS	DEG_APCC_DBOX_1	228:236	Mutation altering degron motif	0.6097
p.M235V	DO24310	LUAD	ICGC	SRSPLHPMS	DEG_APCC_DBOX_1	228:236	Mutation altering degron motif	0.6097
p.R227S	TCGA-55-A48X	LUAD	TCGA	SRSPLHPMS	DEG_APCC_DBOX_1	228:236	Mutation rewiring degron network	0.3056
p.R227S	DO24048	LUAD	ICGC	SRSPLHPMS	DEG_APCC_DBOX_1	228:236	Mutation rewiring degron network	0.3056
p.H244R	TCGA-98-8021	LUSC	TCGA	SRSPLHPMS	DEG_APCC_DBOX_1	228:236	Mutation rewiring degron network	0.1111
p.H244R	DO27468	LUSC	ICGC	SRSPLHPMS	DEG_APCC_DBOX_1	228:236	Mutation rewiring degron network	0.1111
p.P234A	TCGA-B5-A11N	UCEC	TCGA	SRSPLHPMS	DEG_APCC_DBOX_1	228:236	Mutation altering degron motif	0.6392
p.P234A	DO41458	UCEC	ICGC	SRSPLHPMS	DEG_APCC_DBOX_1	228:236	Mutation altering degron motif	0.6392
p.L52V	TCGA-B5-A11N	UCEC	TCGA	LLGTPGES	DEG_SCF_FBW7_1	52:59	Mutation altering degron motif	0.5654
p.L52V	DO41458	UCEC	ICGC	LLGTPGES	DEG_SCF_FBW7_1	52:59	Mutation altering degron motif	0.5654
p.S472I	TCGA-B5-A1MU	UCEC	TCGA	PSSSS	DEG_SPOP_SBC_1	477:481	Mutation rewiring degron network	0.1944
p.S472I	DO41512	UCEC	ICGC	PSSSS	DEG_SPOP_SBC_1	477:481	Mutation rewiring degron network	0.1944
p.E63V	TCGA-BC-A3KF	LIHC	TCGA	LLGTPGES	DEG_SCF_FBW7_1	52:59	Mutation rewiring degron network	0.2222
p.E63V	DO22990	LIHC	ICGC	LLGTPGES	DEG_SCF_FBW7_1	52:59	Mutation rewiring degron network	0.2222
p.E226K	TCGA-CR-7388	HNSC	TCGA	SRSPLHPMS	DEG_APCC_DBOX_1	228:236	Mutation rewiring degron network	0.2778
p.E226K	DO14284	HNSC	ICGC	SRSPLHPMS	DEG_APCC_DBOX_1	228:236	Mutation rewiring degron network	0.2778
p.E487K	TCGA-DK-AA6S	BLCA	TCGA	PSSSS	DEG_SPOP_SBC_1	477:481	Mutation rewiring degron network	0.1667
p.E487K	DO219007	BLCA	ICGC	PSSSS	DEG_SPOP_SBC_1	477:481	Mutation rewiring degron network	0.1667
p.R219W	TCGA-EE-A2GD	SKCM	TCGA	SRSPLHPMS	DEG_APCC_DBOX_1	228:236	Mutation rewiring degron network	0.0833
p.R219W	DO233634	GACA	ICGC	SRSPLHPMS	DEG_APCC_DBOX_1	228:236	Mutation rewiring degron network	0.0833
p.R219W	DO37603	SKCM	ICGC	SRSPLHPMS	DEG_APCC_DBOX_1	228:236	Mutation rewiring degron network	0.0833
p.S470R	TCGA-EO-A22R	UCEC	TCGA	PSSSS	DEG_SPOP_SBC_1	477:481	Mutation blocking phosphorylation signal	0.5833
p.S470R	DO42713	UCEC	ICGC	PSSSS	DEG_SPOP_SBC_1	477:481	Mutation blocking phosphorylation signal	0.5833
p.R67Q	TCGA-G4-6304	COAD	TCGA	LLGTPGES	DEG_SCF_FBW7_1	52:59	Mutation rewiring degron network	0.1111
p.R67Q	DO10639	COAD	ICGC	LLGTPGES	DEG_SCF_FBW7_1	52:59	Mutation rewiring degron network	0.1111
p.R67Q	SIDM01095	Rhabdomyosarcoma	GDSC	LLGTPGES	DEG_SCF_FBW7_1	52:59	Mutation rewiring degron network	0.1111
p.R67Q	ACH-000833	Sarcoma	CCLE	LLGTPGES	DEG_SCF_FBW7_1	52:59	Mutation rewiring degron network	0.1111
p.R67Q	SJRH30	soft tissue	COSMIC	LLGTPGES	DEG_SCF_FBW7_1	52:59	Mutation rewiring degron network	0.1111
p.S471P	DO229016	COCA	ICGC	PSSSS	DEG_SPOP_SBC_1	477:481	Mutation blocking phosphorylation signal	0.6111
p.S471P	DO51043	LAML	ICGC	PSSSS	DEG_SPOP_SBC_1	477:481	Mutation blocking phosphorylation signal	0.6111
p.S471P	DO228245	LICA	ICGC	PSSSS	DEG_SPOP_SBC_1	477:481	Mutation blocking phosphorylation signal	0.6111
p.S471P	DO228553	LICA	ICGC	PSSSS	DEG_SPOP_SBC_1	477:481	Mutation blocking phosphorylation signal	0.6111
p.S471P	DO228931	LICA	ICGC	PSSSS	DEG_SPOP_SBC_1	477:481	Mutation blocking phosphorylation signal	0.6111
p.S471P	DO228947	LICA	ICGC	PSSSS	DEG_SPOP_SBC_1	477:481	Mutation blocking phosphorylation signal	0.6111
p.S471P	DO228950	LICA	ICGC	PSSSS	DEG_SPOP_SBC_1	477:481	Mutation blocking phosphorylation signal	0.6111
p.S471P	DO229022	LICA	ICGC	PSSSS	DEG_SPOP_SBC_1	477:481	Mutation blocking phosphorylation signal	0.6111
p.S471P	DO229047	LICA	ICGC	PSSSS	DEG_SPOP_SBC_1	477:481	Mutation blocking phosphorylation signal	0.6111
p.S471P	DO229008	LICA	ICGC	PSSSS	DEG_SPOP_SBC_1	477:481	Mutation blocking phosphorylation signal	0.6111
p.P234T	DO228952	LICA	ICGC	SRSPLHPMS	DEG_APCC_DBOX_1	228:236	Mutation altering degron motif	0.5919
p.I238V	DO23516	LIRI	ICGC	SRSPLHPMS	DEG_APCC_DBOX_1	228:236	Mutation rewiring degron network	0.2778
p.G57D	DO220889	MELA	ICGC	LLGTPGES	DEG_SCF_FBW7_1	52:59	Mutation altering degron motif	0.6087
p.P477L	DO222653	MELA	ICGC	PSSSS	DEG_SPOP_SBC_1	477:481	Mutation altering degron motif	0.7582
p.E61Q	DO50657	ORCA	ICGC	LLGTPGES	DEG_SCF_FBW7_1	52:59	Mutation rewiring degron network	0.2778
p.H233R	ACH-000961	Endometrial/Uterine Cancer	CCLE	SRSPLHPMS	DEG_APCC_DBOX_1	228:236	Mutation altering degron motif	0.7133
p.P477T	ACH-002302	Leukemia	CCLE	PSSSS	DEG_SPOP_SBC_1	477:481	Mutation altering degron motif	0.7031

Kaplan plot for RLIM in

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*NOTE: the Kaplan plots were collected from OncoLnc

DegronMD: protein-targeted degradation, mutation and drug response to degrons

RLIM

UniProt ID: Q9NVW2

Entrez ID: 51132

Protein name: E3 ubiquitin-protein ligase RLIM (EC 2.3.2.27) (LIM domain-interacting RING finger protein) (RING finger LIM domain-binding protein) (R-LIM) (RING finger protein 12) (RING-type E3 ubiquitin transferase RLIM) (Renal carcinoma antigen NY-REN-43)

External links: UniprotKB HGNC RefSeq COSMIC

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Kaplan plot for RLIM in