DegronMD

Uniprot ID: Q9NVW2

Source protein: E3 ubiquitin-protein ligase RLIM

Source gene: RLIM

Class: DEG_SCF_FBW7_1

Location: 52:59

E3 ligase: FBXW7

DEGRON score: 0.9762

ASA_SCORE: 62.8125

COIL: 0.8921

CONS_SCORE: 0.4024

DSS_SCORE: 0.5743

HELIX: 0.0456

FCONS_SCORE: 1.0693

RIG_SCORE: 0.6374

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.Q69R	TCGA-19-1788	GBM	TCGA	LLGTPGES	DEG_SCF_FBW7_1	0.0556
p.Q69R	DO12712	GBM	ICGC	LLGTPGES	DEG_SCF_FBW7_1	0.0556
p.L52V	TCGA-B5-A11N	UCEC	TCGA	LLGTPGES	DEG_SCF_FBW7_1	0.5654
p.L52V	DO41458	UCEC	ICGC	LLGTPGES	DEG_SCF_FBW7_1	0.5654
p.E63V	TCGA-BC-A3KF	LIHC	TCGA	LLGTPGES	DEG_SCF_FBW7_1	0.2222
p.E63V	DO22990	LIHC	ICGC	LLGTPGES	DEG_SCF_FBW7_1	0.2222
p.R67Q	TCGA-G4-6304	COAD	TCGA	LLGTPGES	DEG_SCF_FBW7_1	0.1111
p.R67Q	DO10639	COAD	ICGC	LLGTPGES	DEG_SCF_FBW7_1	0.1111
p.R67Q	SIDM01095	Rhabdomyosarcoma	GDSC	LLGTPGES	DEG_SCF_FBW7_1	0.1111
p.R67Q	ACH-000833	Sarcoma	CCLE	LLGTPGES	DEG_SCF_FBW7_1	0.1111
p.R67Q	SJRH30	soft_tissue	COSMIC	LLGTPGES	DEG_SCF_FBW7_1	0.1111
p.G57D	DO220889	MELA	ICGC	LLGTPGES	DEG_SCF_FBW7_1	0.6087
p.E61Q	DO50657	ORCA	ICGC	LLGTPGES	DEG_SCF_FBW7_1	0.2778

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q9NVW2	E3 ubiquitin-protein ligase RLIM	DEG_SCF_FBW7_1	52:59	LLGTPGES	FBXW7	0.9762	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons