DegronMD

Uniprot ID: Q9NVW2

Source protein: E3 ubiquitin-protein ligase RLIM

Source gene: RLIM

Class: DEG_APCC_DBOX_1

Location: 228:236

E3 ligase: APC,CDC20,FZR1

DEGRON score: 0.9392

ASA_SCORE: 86.1778

COIL: 0.8973

CONS_SCORE: 0.3564

DSS_SCORE: 0.7602

HELIX: 0.0736

FCONS_SCORE: 1.0051

RIG_SCORE: 0.5537

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.M235V	TCGA-44-7659	LUAD	TCGA	SRSPLHPMS	DEG_APCC_DBOX_1	0.6097
p.M235V	DO24310	LUAD	ICGC	SRSPLHPMS	DEG_APCC_DBOX_1	0.6097
p.R227S	TCGA-55-A48X	LUAD	TCGA	SRSPLHPMS	DEG_APCC_DBOX_1	0.3056
p.R227S	DO24048	LUAD	ICGC	SRSPLHPMS	DEG_APCC_DBOX_1	0.3056
p.H244R	TCGA-98-8021	LUSC	TCGA	SRSPLHPMS	DEG_APCC_DBOX_1	0.1111
p.H244R	DO27468	LUSC	ICGC	SRSPLHPMS	DEG_APCC_DBOX_1	0.1111
p.P234A	TCGA-B5-A11N	UCEC	TCGA	SRSPLHPMS	DEG_APCC_DBOX_1	0.6392
p.P234A	DO41458	UCEC	ICGC	SRSPLHPMS	DEG_APCC_DBOX_1	0.6392
p.E226K	TCGA-CR-7388	HNSC	TCGA	SRSPLHPMS	DEG_APCC_DBOX_1	0.2778
p.E226K	DO14284	HNSC	ICGC	SRSPLHPMS	DEG_APCC_DBOX_1	0.2778
p.R219W	TCGA-EE-A2GD	SKCM	TCGA	SRSPLHPMS	DEG_APCC_DBOX_1	0.0833
p.R219W	DO233634	GACA	ICGC	SRSPLHPMS	DEG_APCC_DBOX_1	0.0833
p.R219W	DO37603	SKCM	ICGC	SRSPLHPMS	DEG_APCC_DBOX_1	0.0833
p.P234T	DO228952	LICA	ICGC	SRSPLHPMS	DEG_APCC_DBOX_1	0.5919
p.I238V	DO23516	LIRI	ICGC	SRSPLHPMS	DEG_APCC_DBOX_1	0.2778
p.H233R	ACH-000961	Endometrial/Uterine Cancer	CCLE	SRSPLHPMS	DEG_APCC_DBOX_1	0.7133

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q9NVW2	E3 ubiquitin-protein ligase RLIM	DEG_APCC_DBOX_1	228:236	SRSPLHPMS	APC,CDC20,FZR1	0.9392	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons