DegronMD - O15040(TECPR2)

Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.G1374C	TCGA-05-4410	LUAD	TCGA	PPGY	ITCH	1372:1375	Mutation altering degron motif	0.6489
p.G1374C	DO25426	LUAD	ICGC	PPGY	ITCH	1372:1375	Mutation altering degron motif	0.6489
p.Y758C	TCGA-23-2649	OV	TCGA	PSSSS	DEG_SPOP_SBC_1	763:767	Mutation rewiring degron network	0.1944
p.Y758C	DO31779	OV	ICGC	PSSSS	DEG_SPOP_SBC_1	763:767	Mutation rewiring degron network	0.1944
p.E773K	TCGA-2F-A9KP	BLCA	TCGA	PSSSS	DEG_SPOP_SBC_1	763:767	Mutation rewiring degron network	0.1667
p.E773K	DO51860	BLCA	ICGC	PSSSS	DEG_SPOP_SBC_1	763:767	Mutation rewiring degron network	0.1667
p.C489S	TCGA-85-6560	LUSC	TCGA	LESTPCSE	DEG_SCF_FBW7_2	484:491	Mutation altering degron motif	0.643
p.C489S	DO26752	LUSC	ICGC	LESTPCSE	DEG_SCF_FBW7_2	484:491	Mutation altering degron motif	0.643
p.E754K	TCGA-85-A53L	LUSC	TCGA	PSSSS	DEG_SPOP_SBC_1	763:767	Mutation rewiring degron network	0.0833
p.E754K	TCGA-EK-A3GM	CESC	TCGA	PSSSS	DEG_SPOP_SBC_1	763:767	Mutation rewiring degron network	0.0833
p.E754K	DO49966	CESC	ICGC	PSSSS	DEG_SPOP_SBC_1	763:767	Mutation rewiring degron network	0.0833
p.E754K	DO45459	LUSC	ICGC	PSSSS	DEG_SPOP_SBC_1	763:767	Mutation rewiring degron network	0.0833
p.E491K	TCGA-A5-A2K5	UCEC	TCGA	LESTPCSE	DEG_SCF_FBW7_2	484:491	Mutation altering degron motif	0.7022
p.E491K	TCGA-AG-A002	READ	TCGA	LESTPCSE	DEG_SCF_FBW7_2	484:491	Mutation altering degron motif	0.7022
p.E491K	DO41379	UCEC	ICGC	LESTPCSE	DEG_SCF_FBW7_2	484:491	Mutation altering degron motif	0.7022
p.G761V	TCGA-AP-A051	UCEC	TCGA	PSSSS	DEG_SPOP_SBC_1	763:767	Mutation rewiring degron network	0.2778
p.G761V	DO42673	UCEC	ICGC	PSSSS	DEG_SPOP_SBC_1	763:767	Mutation rewiring degron network	0.2778
p.D753N	TCGA-BS-A0UV	UCEC	TCGA	PSSSS	DEG_SPOP_SBC_1	763:767	Mutation rewiring degron network	0.0556
p.D753N	DO42793	UCEC	ICGC	PSSSS	DEG_SPOP_SBC_1	763:767	Mutation rewiring degron network	0.0556
p.T769M	TCGA-D1-A15X	UCEC	TCGA	PSSSS	DEG_SPOP_SBC_1	763:767	Mutation rewiring degron network	0.2778
p.T769M	DO43274	UCEC	ICGC	PSSSS	DEG_SPOP_SBC_1	763:767	Mutation rewiring degron network	0.2778
p.L762R	TCGA-D9-A6EC	SKCM	TCGA	PSSSS	DEG_SPOP_SBC_1	763:767	Mutation rewiring degron network	0.3056
p.L762R	TCGA-EO-A3B0	UCEC	TCGA	PSSSS	DEG_SPOP_SBC_1	763:767	Mutation rewiring degron network	0.3056
p.L762R	DO50291	SKCM	ICGC	PSSSS	DEG_SPOP_SBC_1	763:767	Mutation rewiring degron network	0.3056
p.L762R	DO219773	UCEC	ICGC	PSSSS	DEG_SPOP_SBC_1	763:767	Mutation rewiring degron network	0.3056
p.H760N	TCGA-DA-A1IB	SKCM	TCGA	PSSSS	DEG_SPOP_SBC_1	763:767	Mutation rewiring degron network	0.25
p.H760N	DO38033	SKCM	ICGC	PSSSS	DEG_SPOP_SBC_1	763:767	Mutation rewiring degron network	0.25
p.S490F	TCGA-EE-A29N	SKCM	TCGA	LESTPCSE	DEG_SCF_FBW7_2	484:491	Mutation altering degron motif	0.6871
p.S490F	DO38001	SKCM	ICGC	LESTPCSE	DEG_SCF_FBW7_2	484:491	Mutation altering degron motif	0.6871
p.S486L	TCGA-EO-A22R	UCEC	TCGA	LESTPCSE	DEG_SCF_FBW7_2	484:491	Mutation altering degron motif	0.7667
p.S486L	DO42713	UCEC	ICGC	LESTPCSE	DEG_SCF_FBW7_2	484:491	Mutation altering degron motif	0.7667
p.S486L	SIDM01943	Colorectal Carcinoma	GDSC	LESTPCSE	DEG_SCF_FBW7_2	484:491	Mutation altering degron motif	0.7667
p.S486L	SIDM00968	Ovarian Carcinoma	GDSC	LESTPCSE	DEG_SCF_FBW7_2	484:491	Mutation altering degron motif	0.7667
p.S486L	SIDM01215	Ovarian Carcinoma	GDSC	LESTPCSE	DEG_SCF_FBW7_2	484:491	Mutation altering degron motif	0.7667
p.S486L	ACH-000542	Ovarian Cancer	CCLE	LESTPCSE	DEG_SCF_FBW7_2	484:491	Mutation altering degron motif	0.7667
p.S486L	ACH-002140	Ovarian Cancer	CCLE	LESTPCSE	DEG_SCF_FBW7_2	484:491	Mutation altering degron motif	0.7667
p.S486L	Hey	ovary	COSMIC	LESTPCSE	DEG_SCF_FBW7_2	484:491	Mutation altering degron motif	0.7667
p.S496N	TCGA-EO-A3KX	UCEC	TCGA	LESTPCSE	DEG_SCF_FBW7_2	484:491	Mutation rewiring degron network	0.1944
p.S496N	DO219774	UCEC	ICGC	LESTPCSE	DEG_SCF_FBW7_2	484:491	Mutation rewiring degron network	0.1944
p.G775R	TCGA-F4-6570	COAD	TCGA	PSSSS	DEG_SPOP_SBC_1	763:767	Mutation rewiring degron network	0.1111
p.G775R	DO10443	COAD	ICGC	PSSSS	DEG_SPOP_SBC_1	763:767	Mutation rewiring degron network	0.1111
p.P493S	TCGA-FW-A3R5	SKCM	TCGA	LESTPCSE	DEG_SCF_FBW7_2	484:491	Mutation rewiring degron network	0.2778
p.P493S	DO37406	SKCM	ICGC	LESTPCSE	DEG_SCF_FBW7_2	484:491	Mutation rewiring degron network	0.2778
p.P493S	SIDM01781	Gastric Carcinoma	GDSC	LESTPCSE	DEG_SCF_FBW7_2	484:491	Mutation rewiring degron network	0.2778
p.G1374S	TCGA-Q1-A73O	CESC	TCGA	PPGY	ITCH	1372:1375	Mutation altering degron motif	0.5882
p.G1374S	DO51612	CESC	ICGC	PPGY	ITCH	1372:1375	Mutation altering degron motif	0.5882
p.S490C	DO234455	ESAD	ICGC	LESTPCSE	DEG_SCF_FBW7_2	484:491	Mutation altering degron motif	0.643
p.A1363V	DO233882	GACA	ICGC	PPGY	ITCH	1372:1375	Mutation rewiring degron network	0.0833
p.L500F	DO229019	LICA	ICGC	LESTPCSE	DEG_SCF_FBW7_2	484:491	Mutation rewiring degron network	0.0833
p.E768K	DO222753	MELA	ICGC	PSSSS	DEG_SPOP_SBC_1	763:767	Mutation rewiring degron network	0.3056
p.S777N	SIDM01141	Ovarian Carcinoma	GDSC	PSSSS	DEG_SPOP_SBC_1	763:767	Mutation rewiring degron network	0.0556
p.L1380V	SIDM01169	Ovarian Carcinoma	GDSC	PPGY	ITCH	1372:1375	Mutation rewiring degron network	0.1944
p.L1380V	ACH-000885	Ovarian Cancer	CCLE	PPGY	ITCH	1372:1375	Mutation rewiring degron network	0.1944
p.L1380V	TOV-21G	ovary	COSMIC	PPGY	ITCH	1372:1375	Mutation rewiring degron network	0.1944
p.P776S	SIDM00088	Prostate Carcinoma	GDSC	PSSSS	DEG_SPOP_SBC_1	763:767	Mutation rewiring degron network	0.0833
p.P776S	ACH-000090	Prostate Cancer	CCLE	PSSSS	DEG_SPOP_SBC_1	763:767	Mutation rewiring degron network	0.0833
p.P776S	PC-3	prostate	COSMIC	PSSSS	DEG_SPOP_SBC_1	763:767	Mutation rewiring degron network	0.0833
p.S499F	SIDM00306	Non-Small Cell Lung Carcinoma	GDSC	LESTPCSE	DEG_SCF_FBW7_2	484:491	Mutation rewiring degron network	0.1111
p.S499F	ACH-000672	Lung Cancer	CCLE	LESTPCSE	DEG_SCF_FBW7_2	484:491	Mutation rewiring degron network	0.1111
p.S499F	IA-LM	lung	COSMIC	LESTPCSE	DEG_SCF_FBW7_2	484:491	Mutation rewiring degron network	0.1111
p.L762F	SIDM01758	B-Cell Non-Hodgkin's Lymphoma	GDSC	PSSSS	DEG_SPOP_SBC_1	763:767	Mutation rewiring degron network	0.3056
p.L762F	ACH-000285	Lymphoma	CCLE	PSSSS	DEG_SPOP_SBC_1	763:767	Mutation rewiring degron network	0.3056
p.S486T	ACH-000982	Colon/Colorectal Cancer	CCLE	LESTPCSE	DEG_SCF_FBW7_2	484:491	Mutation altering degron motif	0.7116
p.G761R	ACH-001556	Lung Cancer	CCLE	PSSSS	DEG_SPOP_SBC_1	763:767	Mutation rewiring degron network	0.2778

DegronMD: protein-targeted degradation, mutation and drug response to degrons

TECPR2

UniProt ID: O15040

Entrez ID: 9895

Protein name: Tectonin beta-propeller repeat-containing protein 2 (WD repeat-containing protein KIAA0329/KIAA0297)

External links: UniprotKB HGNC RefSeq COSMIC

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Kaplan plot for TECPR2 in