DegronMD

Uniprot ID: O15040

Source protein: Tectonin beta-propeller repeat-containing protein 2

Source gene: TECPR2

Class: DEG_SCF_FBW7_2

Location: 484:491

E3 ligase: FBXW7

DEGRON score: 0.9862

ASA_SCORE: 82.15

COIL: 0.862

CONS_SCORE: 0.3803

DSS_SCORE: 0.5558

HELIX: 0.0719

FCONS_SCORE: 1.1646

RIG_SCORE: 0.6392

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.C489S	TCGA-85-6560	LUSC	TCGA	LESTPCSE	DEG_SCF_FBW7_2	0.643
p.C489S	DO26752	LUSC	ICGC	LESTPCSE	DEG_SCF_FBW7_2	0.643
p.E491K	TCGA-A5-A2K5	UCEC	TCGA	LESTPCSE	DEG_SCF_FBW7_2	0.7022
p.E491K	TCGA-AG-A002	READ	TCGA	LESTPCSE	DEG_SCF_FBW7_2	0.7022
p.E491K	DO41379	UCEC	ICGC	LESTPCSE	DEG_SCF_FBW7_2	0.7022
p.S490F	TCGA-EE-A29N	SKCM	TCGA	LESTPCSE	DEG_SCF_FBW7_2	0.6871
p.S490F	DO38001	SKCM	ICGC	LESTPCSE	DEG_SCF_FBW7_2	0.6871
p.S486L	TCGA-EO-A22R	UCEC	TCGA	LESTPCSE	DEG_SCF_FBW7_2	0.7667
p.S486L	DO42713	UCEC	ICGC	LESTPCSE	DEG_SCF_FBW7_2	0.7667
p.S486L	SIDM01943	Colorectal Carcinoma	GDSC	LESTPCSE	DEG_SCF_FBW7_2	0.7667
p.S486L	SIDM00968	Ovarian Carcinoma	GDSC	LESTPCSE	DEG_SCF_FBW7_2	0.7667
p.S486L	SIDM01215	Ovarian Carcinoma	GDSC	LESTPCSE	DEG_SCF_FBW7_2	0.7667
p.S486L	ACH-000542	Ovarian Cancer	CCLE	LESTPCSE	DEG_SCF_FBW7_2	0.7667
p.S486L	ACH-002140	Ovarian Cancer	CCLE	LESTPCSE	DEG_SCF_FBW7_2	0.7667
p.S486L	Hey	ovary	COSMIC	LESTPCSE	DEG_SCF_FBW7_2	0.7667
p.S496N	TCGA-EO-A3KX	UCEC	TCGA	LESTPCSE	DEG_SCF_FBW7_2	0.1944
p.S496N	DO219774	UCEC	ICGC	LESTPCSE	DEG_SCF_FBW7_2	0.1944
p.P493S	TCGA-FW-A3R5	SKCM	TCGA	LESTPCSE	DEG_SCF_FBW7_2	0.2778
p.P493S	DO37406	SKCM	ICGC	LESTPCSE	DEG_SCF_FBW7_2	0.2778
p.P493S	SIDM01781	Gastric Carcinoma	GDSC	LESTPCSE	DEG_SCF_FBW7_2	0.2778
p.S490C	DO234455	ESAD	ICGC	LESTPCSE	DEG_SCF_FBW7_2	0.643
p.L500F	DO229019	LICA	ICGC	LESTPCSE	DEG_SCF_FBW7_2	0.0833
p.S499F	SIDM00306	Non-Small Cell Lung Carcinoma	GDSC	LESTPCSE	DEG_SCF_FBW7_2	0.1111
p.S499F	ACH-000672	Lung Cancer	CCLE	LESTPCSE	DEG_SCF_FBW7_2	0.1111
p.S499F	IA-LM	lung	COSMIC	LESTPCSE	DEG_SCF_FBW7_2	0.1111
p.S486T	ACH-000982	Colon/Colorectal Cancer	CCLE	LESTPCSE	DEG_SCF_FBW7_2	0.7116

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
O15040	Tectonin beta-propeller repeat-containing protein 2	DEG_SCF_FBW7_2	484:491	LESTPCSE	FBXW7	0.9862	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons

Degron: LESTPCSE

Degron related mutations and impact score

Drug responses associated with TECPR2 mutations

All proteins holding degron of LESTPCSE