DegronMD - A2CJ06(DYTN)

Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.R149Q	TCGA-06-5416	GBM	TCGA	TRRVLRKLL	DEG_APCC_DBOX_1	148:156	Mutation altering degron motif	0.7329
p.R149Q	TCGA-EO-A22R	UCEC	TCGA	TRRVLRKLL	DEG_APCC_DBOX_1	148:156	Mutation altering degron motif	0.7329
p.R149Q	DO233697	GACA	ICGC	TRRVLRKLL	DEG_APCC_DBOX_1	148:156	Mutation altering degron motif	0.7329
p.R149Q	DO10880	GBM	ICGC	TRRVLRKLL	DEG_APCC_DBOX_1	148:156	Mutation altering degron motif	0.7329
p.R149Q	DO42713	UCEC	ICGC	TRRVLRKLL	DEG_APCC_DBOX_1	148:156	Mutation altering degron motif	0.7329
p.R146L	TCGA-44-5644	LUAD	TCGA	TRRVLRKLL	DEG_APCC_DBOX_1	148:156	Mutation rewiring degron network	0.2778
p.R146L	DO25153	LUAD	ICGC	TRRVLRKLL	DEG_APCC_DBOX_1	148:156	Mutation rewiring degron network	0.2778
p.R138S	TCGA-49-6761	LUAD	TCGA	TRRVLRKLL	DEG_APCC_DBOX_1	148:156	Mutation rewiring degron network	0.0556
p.R138S	TCGA-H4-A2HO	BLCA	TCGA	TRRVLRKLL	DEG_APCC_DBOX_1	148:156	Mutation rewiring degron network	0.0556
p.R138S	DO494	BLCA	ICGC	TRRVLRKLL	DEG_APCC_DBOX_1	148:156	Mutation rewiring degron network	0.0556
p.R138S	DO24566	LUAD	ICGC	TRRVLRKLL	DEG_APCC_DBOX_1	148:156	Mutation rewiring degron network	0.0556
p.Q384H	TCGA-62-A46P	LUAD	TCGA	PSSSS	DEG_SPOP_SBC_1	388:392	Mutation rewiring degron network	0.2222
p.Q384H	DO25767	LUAD	ICGC	PSSSS	DEG_SPOP_SBC_1	388:392	Mutation rewiring degron network	0.2222
p.L415S	TCGA-63-A5M9	LUSC	TCGA	DASTGE	DEG_Kelch_Keap1_1	423:428	Mutation rewiring degron network	0.1111
p.L415S	DO223726	LUSC	ICGC	DASTGE	DEG_Kelch_Keap1_1	423:428	Mutation rewiring degron network	0.1111
p.L156V	TCGA-80-5611	LUAD	TCGA	TRRVLRKLL	DEG_APCC_DBOX_1	148:156	Mutation altering degron motif	0.5654
p.L156V	DO23822	LUAD	ICGC	TRRVLRKLL	DEG_APCC_DBOX_1	148:156	Mutation altering degron motif	0.5654
p.K418N	TCGA-A5-A0G2	UCEC	TCGA	DASTGE	DEG_Kelch_Keap1_1	423:428	Mutation substituting flanking lysine	0.3056
p.K418N	DO41235	UCEC	ICGC	DASTGE	DEG_Kelch_Keap1_1	423:428	Mutation substituting flanking lysine	0.3056
p.K418N	SIDM01124	Non-Small Cell Lung Carcinoma	GDSC	DASTGE	DEG_Kelch_Keap1_1	423:428	Mutation substituting flanking lysine	0.3056
p.K418N	ACH-000945	Lung Cancer	CCLE	DASTGE	DEG_Kelch_Keap1_1	423:428	Mutation substituting flanking lysine	0.3056
p.K418N	NCI-H650	lung	COSMIC	DASTGE	DEG_Kelch_Keap1_1	423:428	Mutation substituting flanking lysine	0.3056
p.A424V	TCGA-AA-A00N	COAD	TCGA	DASTGE	DEG_Kelch_Keap1_1	423:428	Mutation altering degron motif	0.5825
p.A424V	DO9876	COAD	ICGC	DASTGE	DEG_Kelch_Keap1_1	423:428	Mutation altering degron motif	0.5825
p.P386L	TCGA-AP-A1DK	UCEC	TCGA	PSSSS	DEG_SPOP_SBC_1	388:392	Mutation rewiring degron network	0.2778
p.P386L	DO42033	UCEC	ICGC	PSSSS	DEG_SPOP_SBC_1	388:392	Mutation rewiring degron network	0.2778
p.R153I	TCGA-B5-A3FA	UCEC	TCGA	TRRVLRKLL	DEG_APCC_DBOX_1	148:156	Mutation altering degron motif	0.6991
p.R153I	DO52402	UCEC	ICGC	TRRVLRKLL	DEG_APCC_DBOX_1	148:156	Mutation altering degron motif	0.6991
p.L159I	TCGA-D3-A2J6	SKCM	TCGA	TRRVLRKLL	DEG_APCC_DBOX_1	148:156	Mutation rewiring degron network	0.25
p.L159I	DO37901	SKCM	ICGC	TRRVLRKLL	DEG_APCC_DBOX_1	148:156	Mutation rewiring degron network	0.25
p.V151L	TCGA-D3-A8GQ	SKCM	TCGA	TRRVLRKLL	DEG_APCC_DBOX_1	148:156	Mutation altering degron motif	0.5654
p.V151L	DO51246	SKCM	ICGC	TRRVLRKLL	DEG_APCC_DBOX_1	148:156	Mutation altering degron motif	0.5654
p.R438I	TCGA-EO-A22U	UCEC	TCGA	DASTGE	DEG_Kelch_Keap1_1	423:428	Mutation rewiring degron network	0.0556
p.R438I	DO43755	UCEC	ICGC	DASTGE	DEG_Kelch_Keap1_1	423:428	Mutation rewiring degron network	0.0556
p.K432T	TCGA-RD-A7BT	STAD	TCGA	DASTGE	DEG_Kelch_Keap1_1	423:428	Mutation substituting flanking lysine	0.3333
p.K432T	DO50131	STAD	ICGC	DASTGE	DEG_Kelch_Keap1_1	423:428	Mutation substituting flanking lysine	0.3333
p.D413N	TCGA-Z2-A8RT	SKCM	TCGA	DASTGE	DEG_Kelch_Keap1_1	423:428	Mutation rewiring degron network	0.0556
p.D413N	DO51301	SKCM	ICGC	DASTGE	DEG_Kelch_Keap1_1	423:428	Mutation rewiring degron network	0.0556
p.S389L	DO10843	ESAD	ICGC	PSSSS	DEG_SPOP_SBC_1	388:392	Mutation altering degron motif	0.6556
p.R149G	DO225420	LAML	ICGC	TRRVLRKLL	DEG_APCC_DBOX_1	148:156	Mutation altering degron motif	0.7568
p.R149G	DO51033	LAML	ICGC	TRRVLRKLL	DEG_APCC_DBOX_1	148:156	Mutation altering degron motif	0.7568
p.E422G	DO228944	LICA	ICGC	DASTGE	DEG_Kelch_Keap1_1	423:428	Mutation rewiring degron network	0.3056
p.D378E	DO229029	LICA	ICGC	PSSSS	DEG_SPOP_SBC_1	388:392	Mutation rewiring degron network	0.0556
p.P145Q	DO229028	LICA	ICGC	TRRVLRKLL	DEG_APCC_DBOX_1	148:156	Mutation rewiring degron network	0.25
p.Q380K	DO229036	LICA	ICGC	PSSSS	DEG_SPOP_SBC_1	388:392	Mutation rewiring degron network	0.1111
p.L379I	DO229008	LICA	ICGC	PSSSS	DEG_SPOP_SBC_1	388:392	Mutation rewiring degron network	0.0833
p.G397V	DO45233	LIRI	ICGC	PSSSS	DEG_SPOP_SBC_1	388:392	Mutation rewiring degron network	0.1944
p.P431S	DO222749	MELA	ICGC	DASTGE	DEG_Kelch_Keap1_1	423:428	Mutation rewiring degron network	0.25
p.E435V	DO232761	PBCA	ICGC	DASTGE	DEG_Kelch_Keap1_1	423:428	Mutation rewiring degron network	0.1389
p.T148P	DO232224	PBCA	ICGC	TRRVLRKLL	DEG_APCC_DBOX_1	148:156	Mutation altering degron motif	0.5919
p.L379P	DO229257	THCA	ICGC	PSSSS	DEG_SPOP_SBC_1	388:392	Mutation rewiring degron network	0.0833
p.L379P	SIDM00538	Esophageal Carcinoma	GDSC	PSSSS	DEG_SPOP_SBC_1	388:392	Mutation rewiring degron network	0.0833
p.L379P	ACH-001497	Esophageal Cancer	CCLE	PSSSS	DEG_SPOP_SBC_1	388:392	Mutation rewiring degron network	0.0833
p.L379P	ESO51	oesophagus	COSMIC	PSSSS	DEG_SPOP_SBC_1	388:392	Mutation rewiring degron network	0.0833
p.T157I	SIDM00845	Burkitt's Lymphoma	GDSC	TRRVLRKLL	DEG_APCC_DBOX_1	148:156	Mutation rewiring degron network	0.3056
p.T157I	SIDM01126	Small Cell Lung Carcinoma	GDSC	TRRVLRKLL	DEG_APCC_DBOX_1	148:156	Mutation rewiring degron network	0.3056
p.T157I	SIDM00309	Mesothelioma	GDSC	TRRVLRKLL	DEG_APCC_DBOX_1	148:156	Mutation rewiring degron network	0.3056
p.T157I	SIDM01605	Non-Small Cell Lung Carcinoma	GDSC	TRRVLRKLL	DEG_APCC_DBOX_1	148:156	Mutation rewiring degron network	0.3056
p.S392Y	SIDM00120	Prostate Carcinoma	GDSC	PSSSS	DEG_SPOP_SBC_1	388:392	Mutation altering degron motif	0.712
p.S392Y	ACH-000979	Prostate Cancer	CCLE	PSSSS	DEG_SPOP_SBC_1	388:392	Mutation altering degron motif	0.712
p.S392Y	DU-145	prostate	COSMIC	PSSSS	DEG_SPOP_SBC_1	388:392	Mutation altering degron motif	0.712
p.G139R	SIDM00122	Breast Carcinoma	GDSC	TRRVLRKLL	DEG_APCC_DBOX_1	148:156	Mutation rewiring degron network	0.0833
p.G139R	ACH-000288	Breast Cancer	CCLE	TRRVLRKLL	DEG_APCC_DBOX_1	148:156	Mutation rewiring degron network	0.0833
p.G139R	BT-549	breast	COSMIC	TRRVLRKLL	DEG_APCC_DBOX_1	148:156	Mutation rewiring degron network	0.0833
p.L159V	SIDM00482	Chronic Myelogenous Leukemia	GDSC	TRRVLRKLL	DEG_APCC_DBOX_1	148:156	Mutation rewiring degron network	0.25
p.L159V	ACH-002302	Leukemia	CCLE	TRRVLRKLL	DEG_APCC_DBOX_1	148:156	Mutation rewiring degron network	0.25
p.L159V	RPMI-8866	haematopoietic and lymphoid tissue	COSMIC	TRRVLRKLL	DEG_APCC_DBOX_1	148:156	Mutation rewiring degron network	0.25
p.P429H	SIDM00047	Non-Small Cell Lung Carcinoma	GDSC	DASTGE	DEG_Kelch_Keap1_1	423:428	Mutation rewiring degron network	0.3056
p.P429H	ACH-002102	Lung Cancer	CCLE	DASTGE	DEG_Kelch_Keap1_1	423:428	Mutation rewiring degron network	0.3056
p.P429H	EMC-BAC-2	lung	COSMIC	DASTGE	DEG_Kelch_Keap1_1	423:428	Mutation rewiring degron network	0.3056
p.T421A	SIDM00114	Non-Small Cell Lung Carcinoma	GDSC	DASTGE	DEG_Kelch_Keap1_1	423:428	Mutation rewiring degron network	0.2778
p.T421A	H513	pleura	COSMIC	DASTGE	DEG_Kelch_Keap1_1	423:428	Mutation rewiring degron network	0.2778
p.Q160H	ACH-001719	Ovarian Cancer	CCLE	TRRVLRKLL	DEG_APCC_DBOX_1	148:156	Mutation rewiring degron network	0.2222

DegronMD: protein-targeted degradation, mutation and drug response to degrons

DYTN

UniProt ID: A2CJ06

Entrez ID: 391475

Protein name: Dystrotelin

External links: UniprotKB HGNC RefSeq COSMIC

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Kaplan plot for DYTN in