DegronMD

Uniprot ID: A2CJ06

Source protein: Dystrotelin

Source gene: DYTN

Class: DEG_APCC_DBOX_1

Location: 148:156

E3 ligase: APC,CDC20,FZR1

DEGRON score: 0.5467

ASA_SCORE: 47.9444

COIL: 0.0878

CONS_SCORE: 0.6271

DSS_SCORE: 0.3354

HELIX: 0.8857

FCONS_SCORE: 1.3393

RIG_SCORE: 0.865

Degron related mutations and impact score

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.R149Q	TCGA-06-5416	GBM	TCGA	TRRVLRKLL	DEG_APCC_DBOX_1	0.7329
p.R149Q	TCGA-EO-A22R	UCEC	TCGA	TRRVLRKLL	DEG_APCC_DBOX_1	0.7329
p.R149Q	DO233697	GACA	ICGC	TRRVLRKLL	DEG_APCC_DBOX_1	0.7329
p.R149Q	DO10880	GBM	ICGC	TRRVLRKLL	DEG_APCC_DBOX_1	0.7329
p.R149Q	DO42713	UCEC	ICGC	TRRVLRKLL	DEG_APCC_DBOX_1	0.7329
p.R146L	TCGA-44-5644	LUAD	TCGA	TRRVLRKLL	DEG_APCC_DBOX_1	0.2778
p.R146L	DO25153	LUAD	ICGC	TRRVLRKLL	DEG_APCC_DBOX_1	0.2778
p.R138S	TCGA-49-6761	LUAD	TCGA	TRRVLRKLL	DEG_APCC_DBOX_1	0.0556
p.R138S	TCGA-H4-A2HO	BLCA	TCGA	TRRVLRKLL	DEG_APCC_DBOX_1	0.0556
p.R138S	DO494	BLCA	ICGC	TRRVLRKLL	DEG_APCC_DBOX_1	0.0556
p.R138S	DO24566	LUAD	ICGC	TRRVLRKLL	DEG_APCC_DBOX_1	0.0556
p.L156V	TCGA-80-5611	LUAD	TCGA	TRRVLRKLL	DEG_APCC_DBOX_1	0.5654
p.L156V	DO23822	LUAD	ICGC	TRRVLRKLL	DEG_APCC_DBOX_1	0.5654
p.R153I	TCGA-B5-A3FA	UCEC	TCGA	TRRVLRKLL	DEG_APCC_DBOX_1	0.6991
p.R153I	DO52402	UCEC	ICGC	TRRVLRKLL	DEG_APCC_DBOX_1	0.6991
p.L159I	TCGA-D3-A2J6	SKCM	TCGA	TRRVLRKLL	DEG_APCC_DBOX_1	0.25
p.L159I	DO37901	SKCM	ICGC	TRRVLRKLL	DEG_APCC_DBOX_1	0.25
p.V151L	TCGA-D3-A8GQ	SKCM	TCGA	TRRVLRKLL	DEG_APCC_DBOX_1	0.5654
p.V151L	DO51246	SKCM	ICGC	TRRVLRKLL	DEG_APCC_DBOX_1	0.5654
p.R149G	DO225420	LAML	ICGC	TRRVLRKLL	DEG_APCC_DBOX_1	0.7568
p.R149G	DO51033	LAML	ICGC	TRRVLRKLL	DEG_APCC_DBOX_1	0.7568
p.P145Q	DO229028	LICA	ICGC	TRRVLRKLL	DEG_APCC_DBOX_1	0.25
p.T148P	DO232224	PBCA	ICGC	TRRVLRKLL	DEG_APCC_DBOX_1	0.5919
p.T157I	SIDM00845	Burkitt's Lymphoma	GDSC	TRRVLRKLL	DEG_APCC_DBOX_1	0.3056
p.T157I	SIDM01126	Small Cell Lung Carcinoma	GDSC	TRRVLRKLL	DEG_APCC_DBOX_1	0.3056
p.T157I	SIDM00309	Mesothelioma	GDSC	TRRVLRKLL	DEG_APCC_DBOX_1	0.3056
p.T157I	SIDM01605	Non-Small Cell Lung Carcinoma	GDSC	TRRVLRKLL	DEG_APCC_DBOX_1	0.3056
p.G139R	SIDM00122	Breast Carcinoma	GDSC	TRRVLRKLL	DEG_APCC_DBOX_1	0.0833
p.G139R	ACH-000288	Breast Cancer	CCLE	TRRVLRKLL	DEG_APCC_DBOX_1	0.0833
p.G139R	BT-549	breast	COSMIC	TRRVLRKLL	DEG_APCC_DBOX_1	0.0833
p.L159V	SIDM00482	Chronic Myelogenous Leukemia	GDSC	TRRVLRKLL	DEG_APCC_DBOX_1	0.25
p.L159V	ACH-002302	Leukemia	CCLE	TRRVLRKLL	DEG_APCC_DBOX_1	0.25
p.L159V	RPMI-8866	haematopoietic_and_lymphoid_tissue	COSMIC	TRRVLRKLL	DEG_APCC_DBOX_1	0.25
p.Q160H	ACH-001719	Ovarian Cancer	CCLE	TRRVLRKLL	DEG_APCC_DBOX_1	0.2222

DegronMD: protein-targeted degradation, mutation and drug response to degrons

Degron: TRRVLRKLL

Degron related mutations and impact score

Drug responses associated with DYTN mutations

All proteins holding degron of TRRVLRKLL

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
A2CJ06	Dystrotelin	DEG_APCC_DBOX_1	148:156	TRRVLRKLL	APC,CDC20,FZR1	0.5467	More...