DegronMD - O15197(EPHB6)

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Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.A476S	TCGA-50-5933	LUAD	TCGA	STSHEVPSA	DEG_COP1_1	482:490	Mutation rewiring degron network	0.1667
p.A476S	DO24800	LUAD	ICGC	STSHEVPSA	DEG_COP1_1	482:490	Mutation rewiring degron network	0.1667
p.A476T	TCGA-55-8094	LUAD	TCGA	STSHEVPSA	DEG_COP1_1	482:490	Mutation rewiring degron network	0.1667
p.A476T	DO24150	LUAD	ICGC	STSHEVPSA	DEG_COP1_1	482:490	Mutation rewiring degron network	0.1667
p.T157K	TCGA-66-2781	LUSC	TCGA	PSSSS	DEG_SPOP_SBC_1	165:169	Mutation rewiring degron network	0.1111
p.T157K	DO26422	LUSC	ICGC	PSSSS	DEG_SPOP_SBC_1	165:169	Mutation rewiring degron network	0.1111
p.T483I	TCGA-A5-A1OF	UCEC	TCGA	STSHEVPSA	DEG_COP1_1	482:490	Mutation altering degron motif	0.5966
p.T483I	DO42568	UCEC	ICGC	STSHEVPSA	DEG_COP1_1	482:490	Mutation altering degron motif	0.5966
p.V497A	TCGA-BB-A5HY	HNSC	TCGA	STSHEVPSA	DEG_COP1_1	482:490	Mutation rewiring degron network	0.1389
p.V497A	DO218979	HNSC	ICGC	STSHEVPSA	DEG_COP1_1	482:490	Mutation rewiring degron network	0.1389
p.V491A	TCGA-CD-A4MG	STAD	TCGA	STSHEVPSA	DEG_COP1_1	482:490	Mutation rewiring degron network	0.3056
p.V491A	DO48009	STAD	ICGC	STSHEVPSA	DEG_COP1_1	482:490	Mutation rewiring degron network	0.3056
p.V491I	TCGA-DK-A1AC	BLCA	TCGA	STSHEVPSA	DEG_COP1_1	482:490	Mutation rewiring degron network	0.3056
p.V491I	DO514	BLCA	ICGC	STSHEVPSA	DEG_COP1_1	482:490	Mutation rewiring degron network	0.3056
p.R499G	TCGA-EE-A3JA	SKCM	TCGA	STSHEVPSA	DEG_COP1_1	482:490	Mutation rewiring degron network	0.0833
p.R499G	DO47625	SKCM	ICGC	STSHEVPSA	DEG_COP1_1	482:490	Mutation rewiring degron network	0.0833
p.E162K	TCGA-FI-A2D5	UCEC	TCGA	PSSSS	DEG_SPOP_SBC_1	165:169	Mutation rewiring degron network	0.25
p.E162K	DO228659	LICA	ICGC	PSSSS	DEG_SPOP_SBC_1	165:169	Mutation rewiring degron network	0.25
p.E162K	DO41331	UCEC	ICGC	PSSSS	DEG_SPOP_SBC_1	165:169	Mutation rewiring degron network	0.25
p.P488L	TCGA-FW-A3R5	SKCM	TCGA	STSHEVPSA	DEG_COP1_1	482:490	Mutation altering degron motif	0.7582
p.P488L	DO37406	SKCM	ICGC	STSHEVPSA	DEG_COP1_1	482:490	Mutation altering degron motif	0.7582
p.S169F	TCGA-MP-A4SV	LUAD	TCGA	PSSSS	DEG_SPOP_SBC_1	165:169	Mutation altering degron motif	0.9093
p.S169F	DO45339	LUAD	ICGC	PSSSS	DEG_SPOP_SBC_1	165:169	Mutation altering degron motif	0.9093
p.S169F	DO220878	MELA	ICGC	PSSSS	DEG_SPOP_SBC_1	165:169	Mutation altering degron motif	0.9093
p.P492L	TCGA-WE-A8ZX	SKCM	TCGA	STSHEVPSA	DEG_COP1_1	482:490	Mutation rewiring degron network	0.2778
p.P492L	DO51291	SKCM	ICGC	STSHEVPSA	DEG_COP1_1	482:490	Mutation rewiring degron network	0.2778
p.A178V	DO233156	GACA	ICGC	PSSSS	DEG_SPOP_SBC_1	165:169	Mutation rewiring degron network	0.0833
p.S482I	DO228938	LICA	ICGC	STSHEVPSA	DEG_COP1_1	482:490	Mutation altering degron motif	0.7341
p.V155E	DO50894	LICA	ICGC	PSSSS	DEG_SPOP_SBC_1	165:169	Mutation rewiring degron network	0.0556
p.P165S	DO220872	MELA	ICGC	PSSSS	DEG_SPOP_SBC_1	165:169	Mutation altering degron motif	0.6752
p.R499Q	DO222415	MELA	ICGC	STSHEVPSA	DEG_COP1_1	482:490	Mutation rewiring degron network	0.0833
p.S499N	SIDM00961	Ewing's Sarcoma	GDSC	STSHEVPSA	DEG_COP1_1	482:490	Mutation rewiring degron network	0.0833
p.S499N	SIDM00298	Squamous Cell Lung Carcinoma	GDSC	STSHEVPSA	DEG_COP1_1	482:490	Mutation rewiring degron network	0.0833
p.S499N	SIDM00279	Gastric Carcinoma	GDSC	STSHEVPSA	DEG_COP1_1	482:490	Mutation rewiring degron network	0.0833
p.A160V	SIDM01617	Endometrial Carcinoma	GDSC	PSSSS	DEG_SPOP_SBC_1	165:169	Mutation rewiring degron network	0.1944
p.A160V	ACH-000994	Endometrial/Uterine Cancer	CCLE	PSSSS	DEG_SPOP_SBC_1	165:169	Mutation rewiring degron network	0.1944
p.I158V	SIDM01387	Small Cell Lung Carcinoma	GDSC	PSSSS	DEG_SPOP_SBC_1	165:169	Mutation rewiring degron network	0.1389
p.I158V	ACH-000921	Lung Cancer	CCLE	PSSSS	DEG_SPOP_SBC_1	165:169	Mutation rewiring degron network	0.1389
p.N481D	SIDM01451	Pancreatic Carcinoma	GDSC	STSHEVPSA	DEG_COP1_1	482:490	Mutation rewiring degron network	0.3056
p.S167F	ACH-000465	Skin Cancer	CCLE	PSSSS	DEG_SPOP_SBC_1	165:169	Mutation altering degron motif	0.7982
p.N480D	ACH-000933	Pancreatic Cancer	CCLE	STSHEVPSA	DEG_COP1_1	482:490	Mutation rewiring degron network	0.2778
p.S171F	ACH-001277	Sarcoma	CCLE	PSSSS	DEG_SPOP_SBC_1	165:169	Mutation blocking phosphorylation signal	0.7222
p.A498V	MOLT-4	haematopoietic and lymphoid tissue	COSMIC	STSHEVPSA	DEG_COP1_1	482:490	Mutation rewiring degron network	0.1111
p.Q479R	TMK-1	stomach	COSMIC	STSHEVPSA	DEG_COP1_1	482:490	Mutation rewiring degron network	0.25
p.V500A	CML-T1	haematopoietic and lymphoid tissue	COSMIC	STSHEVPSA	DEG_COP1_1	482:490	Mutation rewiring degron network	0.0556

Kaplan plot for EPHB6 in

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*NOTE: the Kaplan plots were collected from OncoLnc

DegronMD: protein-targeted degradation, mutation and drug response to degrons

EPHB6

UniProt ID: O15197

Entrez ID: 2051

Protein name: Ephrin type-B receptor 6 (HEP) (Tyrosine-protein kinase-defective receptor EPH-6)

External links: UniprotKB HGNC RefSeq COSMIC

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Kaplan plot for EPHB6 in