DegronMD

Uniprot ID: O15197

Source protein: Ephrin type-B receptor 6

Source gene: EPHB6

Class: DEG_COP1_1

Location: 482:490

E3 ligase: COP1

DEGRON score: 0.9077

ASA_SCORE: 70.6889

COIL: 0.7307

CONS_SCORE: 0.5589

DSS_SCORE: 0.4199

HELIX: 0.0413

FCONS_SCORE: 1.0394

RIG_SCORE: 0.6818

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.A476S	TCGA-50-5933	LUAD	TCGA	STSHEVPSA	DEG_COP1_1	0.1667
p.A476S	DO24800	LUAD	ICGC	STSHEVPSA	DEG_COP1_1	0.1667
p.A476T	TCGA-55-8094	LUAD	TCGA	STSHEVPSA	DEG_COP1_1	0.1667
p.A476T	DO24150	LUAD	ICGC	STSHEVPSA	DEG_COP1_1	0.1667
p.T483I	TCGA-A5-A1OF	UCEC	TCGA	STSHEVPSA	DEG_COP1_1	0.5966
p.T483I	DO42568	UCEC	ICGC	STSHEVPSA	DEG_COP1_1	0.5966
p.V497A	TCGA-BB-A5HY	HNSC	TCGA	STSHEVPSA	DEG_COP1_1	0.1389
p.V497A	DO218979	HNSC	ICGC	STSHEVPSA	DEG_COP1_1	0.1389
p.V491A	TCGA-CD-A4MG	STAD	TCGA	STSHEVPSA	DEG_COP1_1	0.3056
p.V491A	DO48009	STAD	ICGC	STSHEVPSA	DEG_COP1_1	0.3056
p.V491I	TCGA-DK-A1AC	BLCA	TCGA	STSHEVPSA	DEG_COP1_1	0.3056
p.V491I	DO514	BLCA	ICGC	STSHEVPSA	DEG_COP1_1	0.3056
p.R499G	TCGA-EE-A3JA	SKCM	TCGA	STSHEVPSA	DEG_COP1_1	0.0833
p.R499G	DO47625	SKCM	ICGC	STSHEVPSA	DEG_COP1_1	0.0833
p.P488L	TCGA-FW-A3R5	SKCM	TCGA	STSHEVPSA	DEG_COP1_1	0.7582
p.P488L	DO37406	SKCM	ICGC	STSHEVPSA	DEG_COP1_1	0.7582
p.P492L	TCGA-WE-A8ZX	SKCM	TCGA	STSHEVPSA	DEG_COP1_1	0.2778
p.P492L	DO51291	SKCM	ICGC	STSHEVPSA	DEG_COP1_1	0.2778
p.S482I	DO228938	LICA	ICGC	STSHEVPSA	DEG_COP1_1	0.7341
p.R499Q	DO222415	MELA	ICGC	STSHEVPSA	DEG_COP1_1	0.0833
p.S499N	SIDM00961	Ewing's Sarcoma	GDSC	STSHEVPSA	DEG_COP1_1	0.0833
p.S499N	SIDM00298	Squamous Cell Lung Carcinoma	GDSC	STSHEVPSA	DEG_COP1_1	0.0833
p.S499N	SIDM00279	Gastric Carcinoma	GDSC	STSHEVPSA	DEG_COP1_1	0.0833
p.N481D	SIDM01451	Pancreatic Carcinoma	GDSC	STSHEVPSA	DEG_COP1_1	0.3056
p.N480D	ACH-000933	Pancreatic Cancer	CCLE	STSHEVPSA	DEG_COP1_1	0.2778
p.A498V	MOLT-4	haematopoietic_and_lymphoid_tissue	COSMIC	STSHEVPSA	DEG_COP1_1	0.1111
p.Q479R	TMK-1	stomach	COSMIC	STSHEVPSA	DEG_COP1_1	0.25
p.V500A	CML-T1	haematopoietic_and_lymphoid_tissue	COSMIC	STSHEVPSA	DEG_COP1_1	0.0556

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
O15197	Ephrin type-B receptor 6	DEG_COP1_1	482:490	STSHEVPSA	COP1	0.9077	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons

Degron: STSHEVPSA

Degron related mutations and impact score

Drug responses associated with EPHB6 mutations

All proteins holding degron of STSHEVPSA