DegronMD - P48751(SLC4A3)

SLC4A3

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Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.R446H	TCGA-06-5416	GBM	TCGA	PSSSS	DEG_SPOP_SBC_1	441:445	Mutation rewiring degron network	0.3056
p.D434A	TCGA-AA-3949	COAD	TCGA	PSSSS	DEG_SPOP_SBC_1	441:445	Mutation rewiring degron network	0.1389
p.A442T	TCGA-DU-6392	LGG	TCGA	PSSSS	DEG_SPOP_SBC_1	441:445	Mutation altering degron motif	0.7139
p.P438L	TCGA-EO-A22U	UCEC	TCGA	PSSSS	DEG_SPOP_SBC_1	441:445	Mutation rewiring degron network	0.25
p.P455L	TCGA-ER-A19M	SKCM	TCGA	PSSSS	DEG_SPOP_SBC_1	441:445	Mutation rewiring degron network	0.0556
p.R441K	TCGA-IB-7651	PAAD	TCGA	PSSSS	DEG_SPOP_SBC_1	441:445	Mutation altering degron motif	0.7237
p.P187L	DO232224	PBCA	ICGC	VGPHTD	LIG_APCC_ABBA_1	191:196	Mutation rewiring degron network	0.2222
p.R439P	DO48547	STAD	ICGC	PSSSS	DEG_SPOP_SBC_1	441:445	Mutation rewiring degron network	0.2778
p.K432N	DO41020	UCEC	ICGC	PSSSS	DEG_SPOP_SBC_1	441:445	Mutation substituting flanking lysine	0.1944
p.R439Q	DO43041	UCEC	ICGC	PSSSS	DEG_SPOP_SBC_1	441:445	Mutation rewiring degron network	0.2778
p.R439Q	DO43154	UCEC	ICGC	PSSSS	DEG_SPOP_SBC_1	441:445	Mutation rewiring degron network	0.2778
p.H453Y	ACH-000960	Leukemia	CCLE	PSSSS	DEG_SPOP_SBC_1	441:445	Mutation rewiring degron network	0.1111
p.H453Y	REH	haematopoietic and lymphoid tissue	COSMIC	PSSSS	DEG_SPOP_SBC_1	441:445	Mutation rewiring degron network	0.1111
p.S442L	ACH-000994	Endometrial/Uterine Cancer	CCLE	PSSSS	DEG_SPOP_SBC_1	441:445	Mutation altering degron motif	0.6556
p.D433G	GI-ME-N	autonomic ganglia	COSMIC	PSSSS	DEG_SPOP_SBC_1	441:445	Mutation rewiring degron network	0.1111

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*NOTE: the Kaplan plots were collected from OncoLnc