DegronMD: protein-targeted degradation, mutation and drug response to degrons
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BSML
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Degron:
VGPHTD
Uniprot ID:
P48751
Source protein:
Anion exchange protein 3
Source gene:
SLC4A3
Class:
LIG_APCC_ABBA_1
Location:
191:196
E3 ligase:
APC,CDC20,FZR1
DEGRON score:
0.9888
ASA_SCORE:
88.2
COIL:
0.943
CONS_SCORE:
0.3665
DSS_SCORE:
0.7939
HELIX:
0.0257
FCONS_SCORE:
1.1591
RIG_SCORE:
0.5354
Degron related mutations and impact score
Mutation
Sample
Cancer
Dataset
Degron
Degron class
Impact score
p.P187L
DO232224
PBCA
ICGC
VGPHTD
LIG_APCC_ABBA_1
0.2222
Drug responses associated with SLC4A3 mutations
Sample
Cancer
Mutation (In Degron?)
Dataset
Drug
IC50
All proteins holding degron of VGPHTD
Uniprot ID
Source protein
Degron class
Location
Hit
E3 ligase
Degron score
Detail
P48751
Anion exchange protein 3
LIG_APCC_ABBA_1
191:196
VGPHTD
APC,CDC20,FZR1
0.9888
More...